Báo cáo y học: "RANKL inhibition by osteoprotegerin prevents bone loss without affecting local or systemic inflammation parameters in two rat arthritis models: comparison with anti-TNFα or anti-IL-1 therapies" potx

... of local and systemic inflammation, and partiallyreduced local but not systemic bone loss in AIA and CIA rats.RANKL inhibition prevented local and systemic bone loss without significantly inhibiting ... arthriticjoints.Effects of anti-TNFα, anti-IL-1, or anti-RANKL therapy on local and systemic bone loss Local bone loss within inflamed hind paws was evaluated by dual X-ray absorptiometry analysis, with ... without affecting local or systemic inflammation parameters in two rat arthritis models: comparison with anti-TNFα or anti-IL-1 therapiesMarina Stolina1, Georg Schett2,3, Denise Dwyer1,...

Báo cáo y học: " A high serum level of eotaxin (CCL 11) is associated with less radiographic progression in early rheumatoid arthritis patients" doc

... Norway2Faculty of Medicine, University of Oslo, Oslo, Norway3Institute of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, NorwayCorresponding author: ... fromLuminex Corporation, Austin, USA). The multiplex assay sys-tem has been validated against the traditional ELISA sandwichassay for cytokines and found to perform very reliably [5].Measured cytokines ... sensitivity C-reactive protein (hsCRP)was measured by nephelometry (Dade Behring, USA).Cytokine analyses were performed with multiplex fluoroimmu-noassay technology (Biosource Cytokine 25-plex...

Báo cáo Y học: Growth inhibition of mammalian cells by eosinophil cationic protein pptx

... arecapable in some cases of mediating regression of tumors[53,54]. In ammatory in ltrates comprised of eosinophilsmay also play an important role at the primary site of tumorregression by releasing ... that ECP may interact prefe ren-tially with a receptor or binding protein on t he cell surface.We attempted to observe the speci®c binding using ECP andRITC-labeled ECP by monitoring the level ... rowth-inhibitory eect was alsoattenuated by this modi®cation. These results suggest thatgrowth inhibition by ECP is dependent on cell type and iscytostatic.Keywords: cell cycle; colony formation;...

Báo cáo y học: "Strong inhibition of TNF-α production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ 67657, a p38 mitogen-activated protein kinase (MAPK) inhibitor" ppt

... and no inhibition by p38MAPK inhibitor was observed. This latter finding is in accordance with the study by Lai and co-workers showingthat LPS induction of MMP9 in monocytes is mainly regu-lated ... the synovium[10]. The lining layer consists mainly of fibroblasts andmacrophages, both important players in the process of inflammation by the production of cytokines and degradingenzymes. ... mediators produced by macrophages, andindirectly of inflammatory mediators by other cells induced by TNF-α stimulation. Here we investigate the effects of RWJ67657, a p38 MAPK inhibitor, on...

Báo cáo y học: " Functional inhibition of NF-κB signal transduction in αvβ3 integrin expressing endothelial cells by using RGD-PEG-modified adenovirus with a mutant IκB gene" ppsx

... antibody (sc847;Santa Cruz Biotechnology). Blots were blocked in blockingbuffer (5% non-fat drymilk in PBS) for two hours, incubated forone hour with primary antibody diluted in blocking buffer1:200 ... E-selectin [29] and VCAM-1 [30]. We previously reported thatanti-E-selectin antibody-directed PEGylated adenovirus selec-tively homed to inflamed skin in mice with a delayed typehypersensitivity ... initiated by the high affinity bind-ing of the carboxy-terminal 'knob' part of the fiber protein tocoxsacki-adenovirus receptor (CAR), thereby limiting its infec-tion specificity to CAR-positive...

Báo cáo y học: "Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis" doc

... for signs of arthritis in each pawaccording to the following scale: 0 = no swelling or redness/normal paw; 1 = swelling and /or redness in one digit; 2 =swelling and /or redness in two or more ... of inflammatory swelling, cell influx and cartilage damageFigure 2Clinical scores from murine collagen-induced arthritis study 2Clinical scores from murine collagen-induced arthritis study 2. ... calcineurin inhibitorssuch as cyclosporin A and tacrolimus in RA patients [4]. Clin-ical efficacy for both calcineurin inhibitors has been reported,particularly in combination with other DMARDs such...

Báo cáo y học: "Early Inhibition of NF-κB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol)" pot

... activation by plantextracts or constituents has been reported repeatedly [24].Blocking IκB kinase activity has been reported as theunderlying mechanism for restricting NF-κB activation by green ... that bioavailable active principles of Pycnogenol exert anti-inflammatoryeffects by inhibition of proinflammatory gene expression which is consistent with documentedclinical observations. We suggest ... with pharmacokinetics and to identify the active component(s) in plasma samples.Competing interestsThis work was supported by a research grant of HorphagResearch. Z.D. was additionally supported by a...

Báo cáo y học: " Effective inhibition of HCMV UL49 gene expression and viral replication by oligonucleotide external guide sequences and RNase P" pptx

... was studied using a gel-shift assay. In this assay, theEGSs were incubated with the substrate to allow for bind-ing, and the EGS-UL49 mRNA complexes were separated in polyacrylamide gels under ... days postinfection. The viralstocks were prepared by adding an equal volume of 10%skim milk, followed by sonication. The titers of the viralstocks were determined by infecting 2 × 105 foreskinfibroblasts ... mutations in C-EGS324 donot significantly affect the binding affinity of the EGS tothe mRNA sequence but abolish its targeting activity toinduce RNase P cleavage, possibly by disrupting the...

Báo cáo y học: " Trans-inhibition of HIV-1 by a long hairpin RNA expressed within the viral genome" pps

... may lack target sequencesfor trans -inhibition by AS19.Mechanism of trans -inhibition by HIV-lhNef and the AS variantsWe have previously described strong inhibition of HIV-1 by RNAi-inducing ... b.berkhout@amc.uva.nl* Corresponding author AbstractBackground: Human immunodeficiency virus type 1 (HIV-1) can be inhibited by means of RNAsilencing or interference (RNAi) using synthetic short interfering RNAs ... listed in Figure1B, with the number of basepairs in the remaining hairpinstructure in their name. For instance, AS44 has 44 remain-ing basepairs, producing a hairpin of intermediate stabil-ity...

Báo cáo y học: " Correction: Inhibition of HIV Env binding to cellular receptors by monoclonal antibody 2G12 as probed by Fc-tagged gp120" doc

... for citation purposes)RetrovirologyOpen AccessCorrectionCorrection: Inhibition of HIV Env binding to cellular receptors by monoclonal antibody 2G12 as probed by Fc-tagged gp120James M Binley1, ... Biology, The Scripps Research Institute, 10666 North Torrey Pines Rd. La Jolla, CA 92037, USAEmail: James M Binley - jbinley@tpims.org; Stacie Ngo-Abdalla - stacie_ngo@yahoo.com; Penny Moore ... 1Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego CA 92121, USA, 2Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines...

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