... effect of the drug on the regulation of 5-LOX, one of the main enzymes involvedin the synthesis of LTB4 by chondrocytes [4,24].Figure 2Cathepsin K gene expression and protein synthesisCathepsin ... tumor necrosisfactor-α [26], however, the capacity of licofelone to inhibit the synthesis of IL-1β [6-8] may explain, at least in part, the effectof the drug on the synthesis of cathepsin K.Figure ... auto-regulation of 5-LOX gene expressionby licofelone in OA cartilage.IntroductionAlong with the graying of the world's population, osteoarthritis(OA), the most common form of arthritis, is becoming...