Báo cáo khoa học: " The role of NH4Cl and cysteine proteases in Human Papillomavirus type 16 infection" ppsx

... cathepsin B or cathepsin L protease,Cathepsin B and L treatment of HPV16 increases bindingFigure 4Cathepsin B and L treatment of HPV16 increases binding. Reporter virus binding was compared in ... cathepsin BFigure 6Lack of HPV16 Infection in the absence of cathepsin B. HPV16 infection levels in cathepsin B and cathepsin L deficient (-/-) and wild type (+/+) MEF cells were analyzed and ... purposes)edge, the first description of the role of cysteine proteases on a non-enveloped virion.Results Cysteine protease inhibitors inhibit HPV16 infectionTo determine the role of cysteine proteases...

Báo cáo khoa học: The role of evolutionarily conserved hydrophobic contacts in the quaternary structure stability of Escherichia coli serine hydroxymethyltransferase pptx

... binding properties The afﬁnity of wild -type and mutant forms for the cofactor was measured to evaluate the impact of the mutations on the structure of the PLP binding site.Because PLP binding ... interacts with the phosphate moiety of PLP; E57¢ is crucial in the binding of the l-serinehydroxyl group [15] and in the catalysis of the hydrox-ymethyltransferase reaction [16] ; and Y65¢ interactswith ... domains,respectively, and appear to stabilize their protein scaf-folds, allowing the proper positioning of the residuesinvolved in PLP binding, substrate binding and modu-lation of the cofactor’s catalytic...

Báo cáo khoa học: The role of Ureaplasma nucleoside monophosphate kinases in the synthesis of nucleoside triphosphates potx

... [16 18].Interestingly, the sum of ATP and UTP was two-foldhigher than that of CTP and GTP, and the ratio of dATP and dTTP to dCTP and dGTP was also 2 : 1 [16, 17]. This fact is in accordance with the ... after 3 min and thendeclined, while the formation of [3H]ATP was increasedlinearly with time within the ﬁrst 15 min. After 30 min, the reaction reached equilibrium (Fig. 4A). Furtherexperiments ... substrate in a totalvolume of 20 lL. The reaction was initiated by the addition the enzyme (100 ngÆreaction)1for the determination of NTP synthesis rates and 0.5–1 ngÆreaction)1for the deter-mination...

Báo cáo khoa học: The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein ppt

... [15]. In matrix metallopro-teases APMA acts by disrupting the cysteine- zinc bond thatexists between the critical cysteine of the prodomain and the zinc atom of the active site, the so-called cysteine ... for the central role of ADAM10 and conﬁrming thatTACE has a minor role in the a-secretase cleavage of APP in human cells.During the course of the present study it was reportedusing an RNA interference ... critically involved in blood pressure regulation due to its action in generatingangiotensin II and in inactivating bradykinin [1]. The enzyme also has a role in the development of vascularpathology and...

báo cáo khoa học: "The role of 18F-FDG-PET/CT in the preoperative staging and posttherapy follow up of gastriccancer:Comparison with spiral CT" docx

... oravoiding unnucessary laparotomy [17]. The guidelinealso recommends PET for evaluation of therapyresponse and to make the decision of continuing the ongoing therapy or stopping and redirecting the ... chemotherapy programme again.Lesions in the lung in 1 patient and in the proximaljejunal segments of the intestine in another patient werenot FDG avid. So they were accepted as non malignant and ... and CT studies showed completely concordant findings and no additional foci were detected by PET/CT. Of these 16 patients, 2 /16 were in the first group, 12 /16 in Group 2 and 2 /16 in Group3.In...

Báo cáo khoa học: "The role of photoperiod and temperature in the induction and the release of dormancy in Pinus sylvestris L. seedlings" potx

... however. Ins-tead the plants formed more stem units. The role of photoperiod and temperature in the induction and the release of dormancy in Pinus sylvestris L. seedlingsI. ... (1985) Wintertime chan-ges in the fine structure and the ribosomecontent of the buds of Scots pine. In: PlantProduction in the North. (Kaurin A., Junttila O. &Nilsen ... Dormancy breaking treatments of 8 and 4 wk had a dramatic influence,hastening the tilushing rate, especially in the plants with lowest degree of dormancy. In Fig. 3 the same...

Báo cáo khoa học: "The role of high-frequency oscillatory ventilation in paediatric intensive care" pot

... ventilatory support with the prospect of reducing the development of ventilator-induced lung injury. Despitetheoretical advantages and convincing laboratory data, however, the use of high-frequency ... alveolar injury due to overdistension; injury dueto repeated cycles of recruitment/derecruitment, in whichalveolar units open during inspiration and collapse againduring expiration, resulting in the ... ventilation, and isassociated with the development of so-called ventilator-induced lung injury (VILI).There are a number of mechanisms that can lead todevelopment of VILI. These include production of...

báo cáo khoa học: "Prognostic significance of STAT3 and phosphorylated STAT3 in human soft tissue tumors - a clinicopathological analysis" ppt

... western blotting and RT-PCR and drafted the manuscript. LM, and KB, provided the clinical samples and collected clinical information and MRparticipated in the coordination of the study and helped ... activation in sarcomasremain uncertain and need further exploration. More-over, knowledge of the cross-interaction of STAT mole-cules with other critical cellular proteins involved in growth ... tobecome increasingly useful in t he clinical evaluation of such tumors [9].Considering the important role of STAT3 and pSTAT3 in various cancers, our study aimed to analyze the expression levels of...

Tài liệu Báo cáo khoa học: The role of electrostatic interactions in the antitumor activity of dimeric RNases docx

... the dimerinterface of the models or in the surroundings of the mutated residues. The models of RNase A covalent dimers in the exchanging conformation were prepared using the 7RSA structure and ... at the dimer interface of the models or in the surroundings of the hinge loop residues. Likewise, the models of nonex-changing and exchanging HHP-RNase were prepared start-ing from 1Z7X. The ... (rotationangle ‘r’) and variation of the inclination (inclination angle ‘i’) withrespect to the plane of the membrane (parallel to the xy plane).Cter and Nter are the C-terminal and N-terminal structural...

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