... whereas Gins15 could interact directly withPCNA and PriS. Finally, the gene encoding Gins23, which hasbeen detected only in Crenarchaea and Thermococcales,neighbors the gene encoding MCM in all ... H,Marisa L, Durosay P, Ishino Y, Aggerbeck L, Forterre P: Genom-ewide and biochemical analyses of DNA-binding activity ofCdc6/Orc1 and Mcm proteins in Pyrococcus sp. Nucleic AcidsRes 2007, 35:3214-3222.50. ... respectively. Hence, the gene encoding Cdc6 islocated in the vicinity of the genes encoding RFC-s1 and RFC-l in P. aerophilum; RFC-s in H. salinarum; MCM and DP2 in M. maripaludis; and DP1 in...