... process
with the necrotizing and not with the xylan hydrolyzing activity, as the catalytically-impaired Xyn11A variants were
able to complement the lower virulence of the xyn11A mutant. The necrotizing ... contributes
to virulence with its necrotizing activity, not with
its catalytic activity
Judith Noda, Nélida Brito, Celedonio González
*...
... extended conformation, with its
phosphate moiety located in the proximity of the zinc
ion and with the hydroxymethylene group pointing
toward Pro295. DHAP interacts with the catalytically
essential ... hydroxyl group onto the substrate, as observed
in other members of the amidohydrolase superfamily
[24,25]. However, as no structure of complexes with
either the substrat...
... different
sensitivities to the ionic environment, and could
explain their different antibacterial selectivities.
Whether SLPI and trappin-2 act synergistically
together or with other antimicrobial peptides has not
yet ... protease
inhibitors of the chelonianin family showing
the domain organization, disulfide bond
topology (plain line) and the inhibitory loop
(half black disk) of...
... (MSCRAMMs).
These proteins act as virulence factors that allow
S. aureus to adhere to the surface of host cells and to
damaged tissue, and help it to avoid phagocytosis by
neutrophils [3,4].
The fibronectin-binding ... fibrinogen
with a similar affinity to those of FnBPA (2 l
M). The binding site for
FnBPB in fibrinogen was localized to the C-terminus of the c-chain. Lik...
... between their ability to be incorpo-
rated into virions and their ability to undergo aminoa-
cylation [11]. Because the aminoacylation defect of
these tRNA variants was primarily in the K
m
parame-
ter, ... viral
infectivity. Overall, the ability of CyPA to bind both
Gag and CA presents the possibility of two such popu-
lations within virions. Consistent with this hypothesis,...
... obtained do not critically depend
on the other free parameters of the model, a property
of the used function. On the other hand, this means
that the other parameters following from the fit of the
data ... c
total
CSP
Þ
2
þ 4K
app
c
total
DNA
q
Á
ð1Þ
with A
0
c
total
DNA
as the protein expression (mgÆmL
)1
Æs
)1
)in
the absence of CSP, c
total
CSP
, the total concentrati...
... transiently stored and
rerouted to polysomes to be translated [17]. P-bodies
are highly mobile within the cytoplasm, intermittently
attaching to stress granules [14]. Factors such as the
cytoplasmic ... cytometric contour-plots showing GFP and huICOS
expression on NIH3T3 cells transduced with indicated huICOS vectors plus either Roquin
WT
or Roquin
DROQ
vector. The boxes show t...
... BVR-A is likely to involve the B-face hydrogen
atom attached to C4 of the nicotinamide ring and the
two bridging pyrroles (rings B and C) with the linking
C10 methene bridge as the electrophilic ... The dried biliverdin
ditaurate ⁄ silica gel material was loaded onto the column.
The column was washed with 300 mL of ethyl acetate to
remove the reduced quinone. The...
... follows:
dlnv
GS
dt
ðtÞ¼
X
5
i¼1
@lnv
GS
@lnX
i
ðtÞÁ
dlnX
i
dt
ðtÞ¼
X
5
i¼1
H
v
GS
X
i
ðtÞð1Þ
where the sum was taken over the regulatory contri-
butions of all five regulators (denoted by X
i
). The
regulator with the highest regulatory contribution
(H
v
GS
X
i
for the regulatory contribution ... known about the kinetic proper-
ties of the components of the regulatory networ...
... not sufficient to explain the topology
precisely. It may be possible to design the C-terminal
region as the clear transmembrane region by replacing
it with one of the transmembrane-type receptors ... which
means that the ratio of type I to type II is 36 : 64.
These different procedures used to estimate the ratio
of the particles in two topologies lead to almost equa...