Báo cáo y học: "Hepatitis C Treatment: current and future perspectives" doc
Báo cáo y học: "Hepatitis C Treatment: current and future perspectives" doc
... affects [17,12]. As HCV ismainly a chronic disease and progress very slowly there-fore persistent infection is a typical characteristic of dis-ease which can be found i n approximately 75% ... personality changes, evensuicide, depression or acute psychosis. Ribavirin sideeffect included anemia, renal dysfunction of coronaryartery. Fetal abnormality and fatality are important sideeffects ... infected withgenotype 2/3 respond well to standard therapy, treat-ment can be started without liver biopsy [40].Therapy for HCV infectionChronic HCV is treated with a glycoprotein commonlyknown...
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Báo cáo y học: "Hepatitis C Virus Serologic and Virologic Tests and Clinical Diagnosis of HCVRelated Liver Disease"
... therapy. Virological tools include serological assays for anti-HCV antibody detection and serological determination of the HCV genotype, and molecular assays that detect and quantify HCV RNA and ... reaction (PCR), “real-time” PCR or TMA [5]. HCV RNA is extracted and reverse transcribed into a double stranded complementary DNA (cDNA), which is subsequently processed into a cyclic enzymatic ... 1. Current algorithms for the use of HCV virological tools in the treatment of chronic hepatitis C, according to the HCV genotype: genotype 1 (A), genotypes 2 and 3 (B), and genotypes 4, 5 and...
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Báo cáo y học: "Hepatitis C Virus (HCV) Infection and Hepatic Steatosis"
... directly injure the liver but it rather triggers an HCV-specific lymphoproliferation. Through profuse cytokine production and also a direct cytopathic effect, these T cells result in hepatocyte ... distribution and size of the lipid accumulation within the hepatocytes. Microvesicular steatosis that is seen in Reye’s syndrome and Acute Fatty Liver Disease of Pregnancy occurs due to dysfunctions ... most common cause of cryptogenic cirrhosis. [4] NAFLD occurs in the setting of obesity, hyperlipidemia, and diabetes all of which is now accepted under one syndrome called the Metabolic Syndrome....
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Báo cáo y học: "Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) Dual Infection"
... Sci. 2006, 3 606. Dual Infection of HBV and HCV and hepatocellular carcinoma (HCC) HBV and HCV infections are confirmed causes of HCC. What’s the combined effect of HBV and HCV coinfection ... on HCC? Accumulated epidemiological data suggested that coinfection with HBV and HCV could increase the risk for development of HCC. A case-control study [51] conducted in Qidong county (a ... infection, probably including latent infection, may play an important role in carcinogenesis in the patients with HCV infection. Table 2. Coinfection with HBV and HCV and risk of HCC HCC case...
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Báo cáo y học: " Hepatitis C virus genotypes circulating in district Swat of Khyber Pakhtoonkhaw, Pakistan" doc
... gel as DNA size marker and the HCV genotype for each sample was confirmedby HCV genotype-specific PCR band. Gel documentationsystem (Geldoc System, Eppendorf Inc, Germany) wasused for gel photograph. ... Ahmed3AbstractHepatitis C virus (HCV) is the leading cause of chronic hepatitis worldwide and its subtypes/genotypes are clinicallyimportant for clinical management and vaccine development. The present study describes ... design and coordination and gave a critical view of manuscript writing. IU collected epidemiologicaldata, performed genotype analysis and analyzed the data statistically. MIhelped IU in molecular...
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Báo cáo y học: " Hepatitis C virus infection in Brazilian long-distance truck drivers" pptx
... peer review• No space constraints or color figure charges• Immediate publication on acceptance• Inclusion in PubMed, CAS, Scopus and Google Scholar• Research which is freely available for redistributionSubmit ... by the Ethical Commit-tee of the Materno Infantil Hospital in Goiânia city,Goiás state. The participa nts were interviewed to collectsocio-demographic data and possible risk factors forHCV ... 1a-m62321; 1b-m58335; 1c- d14853; 2a-d00944; 2b-d01221; 2c- d50409; 3a-d17763; 3b-d49374; 4a- y1 1604; 5a -y1 3184; 6a -y1 2083 and 6b-d84262. Genotype and subtype are indicated for each branch. The bootstrap...
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Báo cáo y học: "Hepatitis C virus core, NS3, NS4B and NS5A are the major immunogenic proteins in humoral immunity in chronic HCV infection" potx
... Sopanen, R. Tyni, and V. Mäkinen for excellent technical assistance. This study was funded in part by the Medical Research Council of the Acad-emy of Finland, the Finnish Cancer Foundation and the ... immediately upon acceptancecited in PubMed and archived on PubMed Central yours — you keep the copyrightSubmit your manuscript here:http://www.biomedcentral.com/info/publishing_adv.aspBioMedcentralVirology ... 30years chronic HCV infection can progress to cirrhosis in20% of the patients leading to hepatocellular carcinomaroughly in yearly rate of 1–4%. Although the commercialmethodology to detect HCV-specific...
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Báo cáo hóa học: " Hepatitis C virus NS2 and NS3/4A proteins are potent inhibitors of host cell cytokine/chemokine gene expression" potx
... 5'-GTACGGGGATCCTTATCAG-CACTCTTCCATCTCATCGAACTCCTG-3', F gene; 5'-AAAAAAAAGGATCCACCATGGCACGAATCCTAAACCT-CAAAGA-3', 5'-TTTCCCTGGGATCCTTATCACGCCGTCT-TCCAGAACCCG-3' (initiation codon ... 5'-GCAACGCGTCATATTCCTGAGTCCTTCCTTGC-3' and 5'-CCCGGTACCGTCTGTGTCACAGAGAGAAAGGGAG-3'(for IFN-λ3 promoter), 5'-ATGACGCGTGAAATTCAG-GAGTAATCAGATC-3' and 5'-GAGGTACCCGTAGATATT-GCAGATACTTCTG-3' ... pEF-Luc. Promoter fragments of the humanIFN-λ1, IFN-λ3 and IFN-α1 genes were amplified withprimers 5'-GGGACGCGTTTAAACCAATGGCA-GAAGCTCC-3' and 5'-TGCGGTACCGGCTAAATCG-CAACTGCTTCCCCAG-3'...
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Báo cáo y học: "Wegener’s granulomatosis: current and upcoming therapies" pps
... cytotoxicagents in WG. The efficacy of these approaches remaineduncertain until 1973, when Fauci and Wolff explored theimmunologic and clinical effects of CYC and glucocorti-coids in WG [2].CYC ... givenTransitional cell carcinoma of the bladder Urinalysis every 3–6 monthsCytology every 6 monthsCystoscopy in patients with nonglomerular hematuria or abnormal cytologyIf bladder injury present, cystoscopy ... experience in more than five patients.CyclosporinCyclosporin (CSA) is a calcineurin inhibitor that blocks thetranscription of IL-2 and other cytokines in activated T lym-phocytes. A major drawback...
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Báo cáo y học: " Hepatitis B virus genotypes and precore and core mutants in UAE patients" ppt
... respectively[7,8]. Recently, geno-type G was identified in the USA and France[9]. Geno-type H was also recently found in Central America[10].The genotypes and subtypes are useful clinical and ... a correla-tion between the molecular characteristics of the HBVvirus with which a patient was infected and their clinicalcharacteristics. We also verified the frequency of precore and BCP ... 2)FHBS2, 5'-CGT GGT GGA CTT CTC TCA ATT TTC-3';3) RHBS1, 5'-AAA TKG CAC TAG TAA ACT GAGCCA-3'; and 4) RHBS2, 5'-GCC ARG AGA AAC GGRCTG AGG CCC-3'. The positions in...
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