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Báo cáo y học: "Hepatitis B virus core protein with hot-spot mutations inhibit MxA gene transcription but has no effect on inhibition of virus replication by interferon a" pptx

Báo cáo y học:

Báo cáo y học: "Hepatitis B virus core protein with hot-spot mutations inhibit MxA gene transcription but has no effect on inhibition of virus replication by interferon a" pptx

... Hepatitis B virus core protein with hot-spot mutations inhibit MxA gene transcription but has no effect on inhibition of virus replication by interferon a. Virology Journal 2010 7:278.Submit your ... inhib ition of MxA gene tran-scription by WT HBc or its hot-spot mutants has no impact on inhibition of HBV replicatio n by IFN-a,indi-cating MxA may be independent of inhibition of HBVDNA replication ... 7:278http://www.virologyj.com/content/7/1/278Page 6 of 6RESEA R C H Open AccessHepatitis B virus core protein with hot-spot mutations inhibit MxA gene transcription but has no effect on inhibition of virus replication...
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Báo cáo y học: " Hepatitis B virus genotypes and precore and core mutants in UAE patients" ppt

... A. Genotypes E and F were not iso-lated from any of our patients, indicating that these geno-Table 2: Distribution of HBV genotypes by patient ageAge group (years) Genotype A (N) Genotype C ... ninesubtypes on the basis of HBsAg determinants[27], agenetic classification based on the comparison of com-plete genomes has defined eight genotypes of HBV (A toH).Differences in the distribution ... properly cited.Virology Journal 2010, 7:160Table 4: HBV genotypes and their relationship to viral featuresHBV BCP and precore region mutations( no. [%])genotype B CP nt 1858 Precore regionWT...
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Báo cáo y học:

Báo cáo y học: "Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) Dual Infection"

... Gastroenterology 1994;106:1048-1053. 43. Shih CM, Lo SJ, Miyamura T, Chen SY, Lee YH. Suppression of hepatitis B virus expression and replication by hepatitis C virus core protein in HuH-7 ... chronic HCV infection [18]. The result indicated that onset of hepatitis B may reduce the severity of HCV infection but not frequency of chronicity. Similar to this study, Sagnelli [19] reported ... Galimany R, Esteban R, et al. Role of hepatitis B, C, and D viruses in dual and triple infection: influence of viral genotypes and hepatitis B precore and basal core promoter mutations on viral...
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Báo cáo y học:

Báo cáo y học: "Hepatitis B Virus e Antigen Variants"

... from clones with wild-type core promoter sequence), which abolished recognition of both core protein and HBeAg by a rabbit polyclonal antibody (Kim et al., unpublished). This finding is consistent ... disulfide bond HBeAg has a secondary structure quite different from that of core protein [22, 35]. Only one of the two major B cell epitopes of HBeAg is shared with the core protein. HBeAg is not ... a noncytocydal virus, the immune response plays a crucial role in generation of liver injury. Therefore, contribution of the genetic makeup of the host in fulminant hepatitis should not be...
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Báo cáo y học:

Báo cáo y học: " Hepatitis B virus genotypes/subgenotypes in voluntary blood donors in Makassar, South Sulawesi, Indonesia" pps

... http://www.virologyj.com/content/6/1/128Page 4 of 9(page number not for citation purposes)Phylogenetic analysis of pre-S region of HBVFigure 1Phylogenetic analysis of pre-S region of HBV. Phylogenetic ... depend only on virus mutations, but also host factors, and therefore needs further investiga-tion.ConclusionHBV /B and HBV/C are dominant in Makassar, similar with the HBV genotype distribution ... HBVgenotype/subgenotype was identified by genotype-specific PCR method or direct sequencing of pre-S region. Mutations in BCP were identified by direct sequencing of the corresponding region.Results: HBV/B...
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Báo cáo y học: " Severe refractory autoimmune hemolytic anemia with both warm and cold autoantibodies that responded completely to a single cycle of rituximab: a case report" pps

... wasremarkable for hepatosplenomegaly. Subsequently, thepatient underwent a bone marrow biopsy that showed ahypercellular marrow with erythroid hyperplasia, but no evidence of dysplasia or lymphoma. ... reported case of a pa tient with mixed-type AIHA who did not respond to steroid therapy but showed a complete response to only one cycle of rituxi-mab. Refractory AIHA is a difficult condition to man-age, ... thickening with- out deposits visualized on light microscopy. On the basis of the findings of light and electron microscopy andimmunopathology, a diagnosis of nodular glomerulo-sclerosis with no evidence...
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Báo cáo y học: "A 60-year-old man with chronic renal failure and a costal mass: a case report and review of the literature" docx

... latter in the bone tissue. Enhancedactivity of oste oclasts and osteoblasts leads to boneresorption and a reduction of bone mineral concentration with an increased proliferation of fibrous tissue ... did not confirm the other lesionsdescribed on tomography. A tomography-guided biopsyspecimen (Figure 1) was obtained, but histopathologicalanalysis reported normal tissue components.Not being ... asso-ciated with severe renal osteodystrophy.DiscussionBrown tumors are unusual bone lesions that represent alocalized manifestation of OFC induced by hyperpara-thyroidism, independent of its...
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Báo cáo y học: "‘CFTR-opathies’: disease phenotypes associated with cystic fibrosis transmembrane regulator gene mutations" pps

... allergic bronchopulmonary aspergillosis, and possibly evenasthma may also be associated with mutations in the CFTR gene, but those syndromes predominantlyreflect non-CFTR gene modifiers and environmental ... muta-tions may influence the efficiency of normal/abnormalCFTR mRNA transcription to varying degrees. In turn, theseverity of the abnormality in CFTR may relate directly tothe phenotypic expression ... protect against early, classic sino-pulmonary diseaseand a pancreatic phenotype, but clearly other non-CFTRfactors may also be at play (Table 1).Allergic bronchopulmonary aspergillosisAlthough...
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Báo cáo y học: " Implementing the semi-structured interview Kiddie-SADS-PL into an in-patient adolescent clinical setting: impact on frequency of diagnoses" docx

... concept of co-morbid-ity, according to DSM-IV classification diagnostic system,and abandon the ICD-10 philosophy of emphasizing onemain diagnosis in each patient.ConclusionThis study provides ... psy-chopathology: factor structure, reliability, validity, and diag-nostic sensitivity. J Abnorm Child Psychol 1997, 25:487-497.18. Barkley RA, Murphy KR: Attention-Deficit Hyperactivity Disorder: ... 1.5). Only13% of all admissions received only one diagnosis duringthe second period of the study, against 29% during thefirst period.We observed a very significant increase in the number of patients...
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Báo cáo y học: "Hepatitis C virus core, NS3, NS4B and NS5A are the major immunogenic proteins in humoral immunity in chronic HCV infection" potx

... baculovirus-expressed HCV proteins and Western blot analysis inorder to be sure of the specificity of the antibodyresponses to a given protein. One of the drawbacks of theassay is, however, that only antibodies ... 0The prevalence of anti-HCV antibodies were analysed by Western blot analysis with recombinant HCV proteins in 68 patients with chronic HCV infection caused by different genotypes 1, 2, 3 and ... Anti-HCV, Abbott, Wiesbaden,Germany; Innotest HCV Ab IV, Innogenetics, Ghent, Bel-gium; Inno-LIA HCV Ab III update, Innogenetics, Ghent,Belgium). HCV RNA detection was performed by CobasAmplicor...
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