Báo cáo y học: "A role for the histone deacetylase HDAC4 in the life-cycle of HIV-1-based vectors" ppsx
Báo cáo y học: "A role for the histone deacetylase HDAC4 in the life-cycle of HIV-1-based vectors" ppsx
... is involved in the life-cycle of HIV-1-based vectors. Our finding also supports the hypothesisthat cellular DSB repai r proteins are invo lved in PIR. At the same time, these proteins clearly ... required for efficient integration or PIR. On the other hand, some reduce the efficiency of integration. Finally, some are involved in integration site selection.We have studied the role of the histone ... 7:237http://www.virologyj.com/content/7/1/237Page 5 of 10RESEA R C H Open AccessA role for the histone deacetylase HDAC4 in the life-cycle of HIV-1-based vectorsJohanna A Smith1, Jennifer Yeung1, Gary D...
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Báo cáo y học: "A role for age-related changes in TGFβ signaling in aberrant chondrocyte differentiation and osteoarthritis" ppt
... articular cartilage is maintained by the cartilage cells, chondrocytes. Changes in chondrocytes, leading to the inability of these cells to maintain the homeostasis of articular cartilage, can ... collagen [15]. is cytokine causes destruction of cartilage by increasing enzyme activity while decreasing the synthesis of enzyme inhibi-tors [16]. IL-1 can stimulate chondrocytes to produce ... HL: Transforming growth factor beta mimetics: discovery of 7-[4-(4-cyanophenyl)phenoxy]-heptanohydroxamic acid, a biaryl hydroxamate inhibitor of histone deacetylase. Mol Cancer Ther 2002,...
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Báo cáo y học: "A role for MCP-1/CCR2 in interstitial lung disease in children" pps
... levels of MCP-1 were closely related to the effectiveness of corticos-teroid therapy. Given the assumption that MCP-1 andCCR2 are important players in the pathophysiology of ILD in children, the ... variety of cells, including monocytes/macrophages, lymphocytesand airway epithelial cells [4-6]. MCP-1 stimulates colla-gen synthesis and production of the pro-fibrotic factortransforming growth ... attending the Department of Pulmonology andAllergology of the University Children's Hospital of Munich during 1999–2004 were considered for inclusion in this study. Children suspective of...
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Báo cáo y học: "A role for prophylactic antibiotics in necrotizing pancreatitis" doc
... mortality rate compared with controls,but the difference was not statistically significant (27%versus 43%). The originality of this study lies in the ‘early antibiotictreatment’ arm, in which the ... before, andsimilar findings were reported by Cinar and colleagues [4].But in a study by Schwarz and colleagues [5], there was nodifference between prophylactic and early therapeuticadministration ... therapeuticadministration of both meropenem and ciprofloxacin in ananimal model.How to translate these findings in clinicalpracticeAlthough this experimental study suggests an advantage of prophylactic administration...
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Báo cáo y học: "A role for Numb in p53 stabilization" pps
... critical in the regulation of p53.Intriguingly, in the case of Numb it seems unclear whether itis the interaction with MDM2 or the interaction with p53that is key to protecting p53 from ubiquitination ... stage of binding thatis critical for ubiquitination of p53, and it is possible,therefore, that Numb inhibits this second binding stepwithout perturbing the initial p53-MDM2 interaction. In this ... orthrough interaction with the ubiquitin ligase Itch. It isinteresting to note that rather than inhibiting ubiquitination,Numb can enhance the degradation of Gli1 by Itch - againpointing to a rather...
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Báo cáo y học: "A monoclonal antibody against kininogen reduces inflammation in the HLA-B27 transgenic rat" pptx
... signs of arthritis in the tarsal jointswere monitored daily in all of the animals. This assessmentwas performed visually with a scale for swelling (0 to 3) and for erythema (0 to 3) of the hindpaws ... and the distal 10 cm of colon of eachFigure 1Kallikrein–kinin system (KKS)Kallikrein–kinin system (KKS). The KKS is initiated by factor XIIa (FXIIa) or prolylcarboxypeptidase on the endothelial ... that interferes with the cellularbinding of HK, evoked marked anti-inflammatory activity in both the colon and the tarsal joints of HLA-B27 transgenicrats. The onset of anti-inflammatory activity...
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Báo cáo y học: " Clinical implications for Vascular Endothelial Growth Factor in the lung: friend or foe?" ppt
... is predominantlyexpressed in the endothelium of lymphatic vessels.Neuropilin-1, a receptor for semaphorins in the nervoussystem, is also a receptor for the heparin-binding isoforms of VEGF ... and hydrostaticpulmonary edema may be the dilution caused from the alveolar flooding rather than the degree of lung injury[29]. In the early stage of lung injury different insults and proin-flamatory ... following a predisposing injury and in the absence of heart failure [7]. The hallmarks of ALI areincreased capillary permeability, interstitial and alveolaredema, influx of circulating inflammatory...
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Báo cáo y học: "A novel scheme to assess factors involved in the reproducibility of DNA-microarray data" pdf
... preference of the reverse transcriptase enzyme for the Cy3 label and (ii) prolonged exposure to air and light of the dyes increasing the chance of oxidation and / or bleaching. The main contributing ... living resources - the cell factory'. The work of RB, HK, and CdH was supported by SENTER, Ministry of Economic Affairs, in the form of a BTS project. The work of NK was supported by NWO-STW, ... manufacturing DNA-microarrays to performing the actual experiments, systematic errors and / or bias in the data are introduced in each of the different steps. The effects of various factors (e.g. dye...
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Tài liệu Báo cáo khoa học: A role for the intersubunit disulfides of seminal RNase in the mechanism of its antitumor action docx
... cannot fit into the horseshoe cavity of the inhibitor, whereas a monomeric form of the enzymecan, and is fully inhibited by CRI. Indeed, monomericRNases lacking cytotoxic activity, such as bovine ... the dimeric structure of the enzyme is essential for its display of cytotoxic activity[3]. This conclusion was based on the lack of cytotoxicactivity in a monomeric derivative of the protein ... thusblocking protein synthesis and leading cells to death. The current model proposed for the mechanism of antitumouraction of BS-RNase is based on the ability of the proteinto resist the neutralizing...
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