... signal-regulated kinase pathways are involved in osteoclast differentiation. Bone 2002, 30:71-77.15. Nakamura I, Takahashi N, Sasaki T, Tanaka S, Udagawa N, Murakami H, Kimura K, Kabuyama Y, Kurokawa ... orsafranin O to assess hyperplasia of synovial tissue, infil-tration of leukocytes, and destruction of cartilage. Eachparameter was graded separately and assigned a severityscore as follows: grade ... Plasma TRACP5b levels were mea-sured using a mouse TRAP™ Assay (ImmunodiagnosticSystem Ltd).Statistical analysisStatistical significance of differences was assessed by one-way analysis of variance...