... e arginine deiminase , resistance, RNA interferenceBackgroundArginine deiminase depletes arginine by hydrolyzing itto ci trulline. Pegylated recombinant arginine deiminase(rADI) has been used ... argininosuccinate synthetaserestores sensitivity to recombinant argininedeiminase (rADI) in resistant cancer cellsFe-Lin Lin Wu1,2,3, Yu-Fen Liang1, Yuan-Chen Chang1, Hao-Hsin Yo1, Ming-Feng ... Taiwan) and maintained in mediumrecommended by ATCC, supplemented with 10% (v/v)heat-inactivated fetal bovine serum (Invitrogen, Auck-land, N Z) and 0.5% penicillin-streptomycin (Invitrogen,Grand...