... ANA responses. Furthermore, immune complexes of ANAscan drive the production of proinflammatory cytokines, inducing the interferon signature’, and intensifying disease. Together, thesefindings ... originally in in vitro culture systems, the blood of SLEpatients contains a factor that can induce the production of IFN-α by IFN-producing cells, also called plasmacytoiddendritic cells. Original ... TLR and non-TLR receptors, whichprobably respond to the nucleic acid components of the complexes. Because complexes may promote uptake intocells, the nucleic acid component may have access to...