... 762–765.55 Funayama M, Hasegawa K, Ohta E, Kawashima N,Komiyama M, Kowa H, Tsuji S & Obata F (2005) AnLRRK2 mutation as a cause for the parkinsonism in the original PARK8 family. Ann Neurol 57, ... ceramidemetabolism.Neurodegeneration with brain iron accumulation-2(NBIA-2) is characterized by the disruption of cellularmechanisms leading to the accumulation of iron in the basal ganglia. Mutations in the gene PLA2G6 ... the GBA mutations.AcknowledgementsThis research was supported in part by the IntramuralResearch Program of the National Institute on Aging,National Institutes of Health, Department of Healthand...