báo cáo khoa học: " Debunking the claim that abstinence is usually healthier for smokers than switching to a low-risk alternative, and other observations about anti-tobacco-harm-reduction arguments" potx

... JournalOpen AccessAnalytic perspective Debunking the claim that abstinence is usually healthier for smokers than switching to a low-risk alternative, and other observations about anti-tobacco-harm-reduction ... that require an analytic approach to show they are misleadingor of minor consequence.An example of such analysis is the debunking of the claim that if we allow smokers to learn that they have ... instead switch to a low-risk product, and theywill suffer greater risks than they otherwise would, and that this constitutes an argument against THR. Debunking this requires the additional analysis...

Báo cáo khoa hoc:" Complicated Crohn''''s-like colitis, associated with Hermansky-Pudlak syndrome, treated with Infliximab: a case report and brief review of the literature" pot

... patient had perianal disease with inflam-mation and fistula, a complication characteristic ofCrohn's disease that has been previously described bySherman et al in 1989 [8] and by Hazzan ... our case suggest that HPS and Crohn's disease may truly be associated. Given this similarity and the failure of the standard medical therapy of corticosteroids and azathioprine, our patient ... to lower GI bleeding, intractable colitis or perianaldisease [3]. The granulomatous colitis associated withHPS usually manifests in the first and second decades and has been described as having...

báo cáo khoa học: " Investigating the complementary value of discrete choice experiments for the evaluation of barriers and facilitators in implementation research: a questionnaire survey" pot

... into the trade-offs people make between barriers to change on the onehand and facilitators on the other hand.Table 4: Health care professionals' perceptions about potential barriers and ... measure the perceived barri-ers and facilitators that may not reflect the actual barriers and facilitators. The results of a DCE are likely to give a more objective view of the factors that are ... conception and design of the study and planning of the work that led to the manuscript, the acquisition, and interpretation of data, and has been involved in drafting and critically revising the manuscript...

Tài liệu Báo cáo khoa học: Seeking the determinants of the elusive functions of Sco proteins pptx

... eukaryotesanalysed, with the exceptions of the microsporidiaEncephalitozoon cuniculi and Encephalitozoon intestinal- is, the amoebae Entamoeba dispar and Entamoebahistolytica, and the apicomplexan Cryptosporidiumparvum. ... 100516804100517855XP_003126813.1XP_003132044.1Branchiostoma ﬂoridae Animals Other animals 1 7233239 XP_002613836.1Hydra magnipapillata Animals Other animals 1 100198802 XP_002156667.1Ixodes scapularis Animals Other animals 1 8026286 ... proline,adjacent to the CXXXC motif, into a leucine (P174L) is associated with a fatal neonatal hepatopathy. Thispathology is caused by a loss of normal Sco1 functionrather than gain of some aberrant action...

Tài liệu Báo cáo khoa học: Resolving the native conformation ofEscherichia coli OmpA docx

... rotor) at 4 °C. His–OmpA wasextracted and purified by Ni2+–agarose chromatography asdescribed by the manufacturer (Qiagen, Valencia, CA,USA). Alternatively, His–OmpA was extracted with LDS and ... intermediate into the large-pore conformation, and they distinguish two important physiological strategiesused to facilitate OmpA targeting and folding – cOHB-modification and disulfide bond formation. ... the extract to convert volatile crotonic acid to crotonate, and the dichloromethane was evaporated with a stream of nitrogen. The residue was acidified by the addition of 2.5 m sulfuricacid and...

Tài liệu Báo cáo khoa học: Understanding the binding properties of an unusual metal-binding protein ) a study of bacterial frataxin pdf

... 4207Understanding the binding properties of an unusualmetal-binding protein) a study of bacterial frataxinChiara Pastore1, Marisa Franzese2, Filomena Sica2,3, Pierandrea Temussi1,2 and Annalisa ... Schagerlof U, Gakh O, Park S, Ryde U,Lindahl M, Leath K, Garman E, Isaya G & Al-Kara-daghi S (2006) The structures of frataxin oligomersreveal the mechanism for the delivery and detoxiﬁcationof ... bleaching of the same peaks that are affectedin the titration of the apoprotein. We observed, in par-ticular, the disappearance of residue 23. This suggests that Mn2+can displace Ca2+at...

Tài liệu Báo cáo khoa học: Malaria)the global disease docx

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Tài liệu Báo cáo khoa học: Probing the molecular determinants of aniline dioxygenase substrate speciﬁcity by saturation mutagenesis docx

... transformed intoE. coli BL21(DE3)Activityagainst 2MAatdA1 pACYC A2 and pET A3 A 4A5 –atdA2 pACYC A1 and pET A3 A 4A5 +atdA3 pACYC A1 A2 and pET A4 A5 –Control (no deletion) pACYC A1 A2 and pET A3 A 4A5 +E. ... range of candidates for saturation mut-agenesis studies, a gene deletion assay was carried out to identify the subunit(s) critical for AtdA activity. The atdA1, atdA2 and atdA3 genes were targeted ... acetate. The ethyl acetate was then evaporated with a rotary evaporatorunder vacuum at 40 °C, and the residue was dissolved in5 mL of methanol. The sample was then analyzed by LC-MS with an...

Tài liệu Báo cáo khoa học: Glucuronate, the precursor of vitamin C, is directly formed from UDP-glucuronate in liver pptx

... indicating that the cofactorwas heat stable. This heat-stable cofactor was dependenton ATP-Mg for its action and the inhibition that it exer-ted together with ATP-Mg was antagonized by metyra-pone, ... UDP-glucuronate and UDPGlcNAc, and the assay was initiated by addition of these two nucleotides.Where indicated, the assay was initiated by the addition of the enzyme preparation to an otherwise complete assaymixture. ... Mentlein R, Schmalz R, Schwabe C &Wagenmann F (1979) A method for the estimation ofesterase synthesis and degradation and its application to evaluate the inﬂuence of insulin and glucagon. Eur...

Tài liệu Báo cáo khoa học: On the mechanism of action of the antifungal agent propionate Propionyl-CoA inhibits glucose metabolism in Aspergillus nidulans doc

... Propionyl-CoA is formed from propionate, CoASH and ATP catalysed b yacetyl-CoA synthetase, F acA [4,5], and by an additionalacyl-CoA synthetase. The condensation of p ropionyl-CoAwith oxaloacetate ... Fab4-J3 strain seemed to be suitable to measure mainly the acetate and propionate activatingactivity of acetyl-CoA synthetase. I n comparison SMB/acuA carries a defective acetyl-Co A synthetase gene, ... MDH a nd citrate synthase and the r esulting absorbanceat 340 nm was measured (A 1). MDH was added and the absorbance after r eaching t he equilibrium was taken as A 2.Citrate synthase was added...

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