báo cáo khoa học: " High prevalence of HIV infection among homeless and street-involved Aboriginal youth in a Canadian setting" potx

... JournalOpen AccessBrief report High prevalence of HIV infection among homeless and street-involved Aboriginal youth in a Canadian settingBrandon DL Marshall1,2, Thomas Kerr1,3, Chris Livingstone4, ... Canada; however, less is known regarding the prevalence and characteristics of HIV positivity among drug-using and street-involved Aboriginal youth. We examined HIV seroprevalence and risk factors ... at-risk Aboriginal youth in two cities in BritishColumbia [12]. The prevalence of HIV among Aboriginal youth in this setting is also substantially higher than thosethat have been observed among...

báo cáo khoa học: " High rates of midazolam injection among drug users in Bangkok, Thailand" pptx

... Chiang Mai, Thailand. International J Drug Policy2005, 16:115-121.7. Poshyachinda V, Na Ayudhya AS, Aramrattana A, Kanato M,Assanangkornchai S, Jitpiromsri S: Illicit substance supply and abuse ... 7:7http://www.harmreductionjournal.com/content/7/1/7Page 6 of 6RESEARC H Open Access High rates of midazolam injection among drugusers in Bangkok, ThailandThomas Kerr1,2*, Niyada Kiatying-Angsulee3, Nadia Fairbairn1, Kanna Hayashi1, ... Orelind K, Choopanya K: Trends in the injection of midazolam and other drugs and needle sharing among injection drug users enrolled in the AIDSVAX B/E HIV- 1 vaccinetrial in Bangkok, Thailand. International...

báo cáo khoa học: " Oncocytic carcinoma of the parotid gland with late cervical lymph node metastases: a case report" potx

... mainlyfound in glandular tissue, accounting for 0.5% of all epithelial salivary gland malignancies and 0.18% of all epithelialsalivary gland tumors.Case presentation: We report a case of oncocytic car ... glands,accounting for just 0.5% of all epithelial salivary glandmalignancies and 0.18% of all epithelial sa livary glandtumors [5]. Criteria for the diagnosis of malignancy in Figure 1 A) ... cinoma arising in the parotid gland of a 65-year-oldCaucasian man. Our patient initially underwent left superficial parotidectomy, including the removal of the mass. A close follow-up was made,...

báo cáo khoa học: "Predicting prognosis of breast cancer with gene signatures: are we lost in a sea of data?" docx

... breast cancer is a single disease, and all Abstract A large number of prognostic and predictive signatures have been proposed for breast cancer and a few of these are now available in the clinic ... signatures are equally ready for clinical use.Before adoption in the clinic, a molecular diagnostic assay has to be standardized, the reproducibility within and between laboratories and stability ... called luminal A) ; and high grade, highly proliferative ER-positive cancers (luminal B). Several smaller and less stable molecular subsets (such as normal-like, HER-2-positive and claudin-low)...

Báo cáo y học: " Protective effects of hydrogen-rich saline on monocrotaline-induced pulmonary hypertension in a rat model" potx

... Hayashida K, Sano M, Ohsawa I, Shinmura K, Tamaki K, Kimura K, Endo J,Katayama T, Kawamura A, Kohsaka S, Makino S, Ohta S, Ogawa S, Fukuda K:Inhalation of hydrogen gas reduces infarct size in ... the manuscript. XJS and XMZconceived and designed and coordinated the study, analyzed the data, and wrote the manuscript. JJH performed the analyses and participated in dataacquisition. ZLX and ... Taishan Medical University, Taian271000, P.R.China.2Province Key Laboratory of Oral and Maxillofacial, Head and Neck Medical Biology Laboratory, Liaocheng People’s Hospital, TaishanMedical University,...

Báo cáo khoa học: "Proton nuclear magnetic resonance spectroscopy based investigation on propylene glycol toxicosis in a Holstein cow" potx

... pulmonary alveoli and the blood and not caused by changes in oxygen affin-ity of haemoglobin (both oxygen tension and saturationdecreased in parallel) and the breathing of the cowappeared to ... was applied on ruminal fluids and blood plasma samplesobtained before and after feeding with PG.Results: PG toxicosis was characterized by dyspnea and ruminal atony upon intake of concentratecontaining ... 512 data points and 32 tran-sients per increment, and the spectra were zero filled in both dimensions.Post-processing and multivariate data analysisPrincipal component analysis (PCA) was applied...

Tài liệu Báo cáo khoa học: High activity of human butyrylcholinesterase at low pH in the presence of excess butyrylthiocholine pptx

... essential features of the catalyticsite (i.e. a catalytic triad of Ser-His-Glu, an oxyanion hole, a p-cation-binding site, and an acyl-binding pocket) are thesame in AChE and BuChE (Fig. 1). The acyl-bindingpocket, ... histidine and carboxylate (aspartate in chymotrypsin, glutamate in cholinesterases) of the cata-lytic triad. Compression of the His-Asp/Glu diad causesthe basicity of the histidine to increase, ... theresponse of cholinesterases to excess-substrate bindingappears to involve the intricate interplay of a variety of residues in the active site.pH dependence of A3 28WThe A3 28W mutant has a remarkable...

Báo cáo khoa học: High levels of structural disorder in scaffold proteins as exempliﬁed by a novel neuronal protein, CASK-interactive protein1 pot

... in vitro datasuggest that the proline-rich fragments of C-terminalCaskin1 are functional and may interact with SH3domain-containing proteins, such as Abi2. [We havealso found an in vivo association ... Caskin1 fragmentsAs described in the introductory paragraphs, theN-terminal half of Caskin1 contains a number of well-known domains involved in protein–protein inter-action, such as the ankyrin ... domain (PRD) in this work. Caskin1 can bind the Cask adaptor protein[1], Abl-interactor-2 (Abi2), and another nine proteinsshown in this work, and is presumably involved in the signal pathway...

Báo cáo khoa học: Identiﬁcation of RNase HII from psychrotrophic bacterium, Shewanella sp. SIB1 as a high-activity type RNase H pot

... Kanaya S, Katsuda C, Kimura S, Nakai T, Kitakuni E,Nakamura H, Katayanagi K, Morikawa K & IkeharaM (1991) Stabilization of Escherichia coli ribonucleaseH by introduction of an artiﬁcial ... roles of RNases H in DNA replication and repair. Genes Cells 5,789–802.6 Haruki M, Tsunaka Y, Morikawa M & Kanaya S(2002) Cleavage of a DNA–RNA–DNA ⁄ DNA chimericsubstrate containing single ... S, Oda Y, Nakai T, Katayanagi K, Kitakuni E,Katsuda-Nakai C, Nakamura H, Ikehara M & KanayaS (1992) Effect of the cavity-modulating mutations onthe stability of E. coli ribonuclease HI....

Báo cáo khoa học: Crystal structures of HIV protease V82A and L90M mutants reveal changes in the indinavir-binding site potx

... 6A) . In PR, the two Cc atoms of Val82formed van der Waals contacts with indinavir, of 3.8 A ˚ .In PRV8 2A , the change in the position of the main chainatoms placed the Cb atom of Ala82 within ... was a smallmovement of the main chain atoms of residues 81–82towards indinavir in PRV8 2A , which partly compensatedfor the change from Val82 in PR to the smaller side chain of Ala (Fig. 6A) . ... within reasonable vander Waals distance of indinavir (4.1 A ˚), resulting in a loss of only one contact compared to PR. In contrast, studies of an inactive protease containing the mutations D25N/V82A...

Xem thêm