báo cáo khoa học: " Awareness of the need for safe storage of Methadone at home is not improved by the use of protocols on recording information giving" doc

... record that they have given information about how to safely store methadone to eachpatient and for the patient to sign that they had been given the information. A 10% (40) sample of sets of patients'notes ... (92.9%) said theywould provide some form of measuring device on request.3. Provision of information on safety issuesOnly 8 (28.6%) pharmacists reported giving information about safe storage. 3 ... audit identifiedrisks to patients and families from the unsafe storage of methadone at home[ 4]. It was found that recall of provi-sion of information on safety issues was poor. The auditsuggested...

Tài liệu Báo cáo khoa học: A systems biology approach for the analysis of carbohydrate dynamics during acclimation to low temperature in Arabidopsis thaliana doc

... depends on the concentration of the reaction product and the dissociation constant Ki,B for inhibitor binding. The rate of hexose-based sucrose synthesis was described by the mass action rate law:rA!BðtÞ¼k ... correlation of sucrose synthesisand degradation with the process of cold acclimation.We conclude that acclimation to low temperature rep-resents a dynamic process, the investigation of whichtherefore ... 1). The rate of net starch synthesis (rCO2!Starch)was deter-mined by interpolation of measured starch contents(unit: C6) and calculation of the ﬁrst derivative of thisfunction. The ﬂux...

Tài liệu Báo cáo khoa học: a-Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes doc

... targeted in this preparation.Mutagenesis studies on PnIA and PnIB have provideduseful information on the binding mode of a-conotoxins[53,58] and the activation states of the nAChR. At the a7[L247] ... concentrations, protocols for toxin application or determination of the toxin concentration) have to be considered.a-Conotoxin SequenceaFunctional DataBinding Data (nM)cIC50(nM) on recombinant ... a-conotoxins, together with the possibility of obtaining detailed information on their three dimen-sional structures and the relative ease of synthesis, makesthem particularly useful templates for the design...

Báo cáo khoa học: Structural and functional roles for b-strand 7 in the a-crystallin domain of p26, a polydisperse small heat shock protein from Artemia franciscana pdf

... correlatedwith the greatest loss of function. Although mutation R114A had the greatest effect on p26 chaperoning, it had the least on oligomerization.These results demonstrate that in contrast ... with the ratio rising as the molecular mass of the substrate increases [58]. For human aB-crystallin, the ratio is 1 : 1 [48]. The p26chaperone activity therefore approximates that of other ... aA-crystallin at 37 °Cbut not 25 °C [51]. Mutation R114A had the leasteffect on p26 oligomerization but the greatest conse-quence for function, demonstrating that chaperoning is independent of oligomerization.All...

Báo cáo khoa học: Structural and functional evidence for a singular repertoire of BMP receptor signal transducing proteins in the lophotrochozoan Crassostrea gigas suggests a shared ancestral BMP/activin pathway docx

... and XI of the receptor serine ⁄ threonine kinase domain [22]. Anotherstriking point is the phase conservation of the intron–exon boundaries that lie either side of the exon enco-ding the extracellular ... fact that, even in the presence of an abnor-mally high concentration of type I BMP recep-tor, enhanced signalling is limited by the endogenousligand concentration. Expression of truncated Cg-BMPR1 ... Moreover, the pattern of tbx6 and gsc expression indicated that the observed dorsalization was due to inappropriateexpansion of the dorsal mesoderm with a concomitantreduction in the ventral...

Báo cáo khoa học: Two separate regions essential for nuclear import of the hnRNP D nucleocytoplasmic shuttling sequence ppt

... parameters of the association rate constants(ka), dissociation rate constants (kd) and dissociationconstants (KD) of D02, DNS, and DNS mutants for Trn-1 were determined at various concentrations ... concentration of 4 lm DNS, but not at a highconcentration of 1 lm Trn-1. This indicates that the translocation of the substrate–Trn-1 complex throughNPCs to the nucleoplasmic side is independent of ... import is mediated by a nucleartransport receptor of Trn, but not other importins. Use of the reconstituted transport mixture instead of reticu-locyte lysates indicated that DNS accumulation in the nucleus...

Báo cáo khoa học: "A Unified Statistical Model for the Identification of English BaseNP" pptx

... output of POStagging, rather that only one, the F-measure of baseNP identification is improved from 93.02 %to 93.07%. After considering baseNP information, the error ratio of POS tagging is reduced ... benefit from baseNP information. Whether or not the baseNP information canimprove the precision of POS tagging in ourapproach is determined by the identifierassignment of the baseNP rules when ... so as toimprove the precision of both baseNP and POStagging. This is one of our further researchtopics.(2) Our statistical model makes use of morelexical information than other approaches....

Báo cáo khoa học: An a-proteobacterial type malate dehydrogenase may complement LDH function in Plasmodium falciparum Cloning and biochemical characterization of the enzyme potx

... in the d irection of oxidation of malate, the ratio o f OAA to malate should be very small.Malate oxidation therefore could be observed at pH > 9.5and only with high concentrations of malate ... with saturating concentrations of the substrate and the cofactor. For enzyme kineticstudies, assays were performed a t varying concentrations of substrates (OAA or malate) and the cofactors [NAD/H ... malate oxidationwas highly alkaline (pH 10.2). The saturating concentration for OAA was only 250 lMwhile for malate it was quite high(20 mM). Malate oxidation at physiological pH is of interest,...

Báo cáo khoa học: Cell death-inducing DFF45-like effector, a lipid droplet-associated protein, might be involved in the differentiation of human adipocytes pdf

... gestation in humans, and that the second tri-mester of gestation is the critical period in adipogenesis.After the 23rd week of gestation, although the number of fat cells remains constant, the ... pre-adipocytes.Discussion The differentiation of adipocytes is the process of for- mation of new adipocytes from pre-adipocyte precur-sors, and is accompanied by the up-regulation of genesencoding ... 5E). These datademonstrate that CIDEC can contribute to the accu-mulation of neutral lipid and the maturation of lipiddroplets, which are key features of differentiatedadipocytes. Loss of CIDEC...

Báo cáo khoa học: "A Feedback-Augmented Method for Detecting Errors in the Writing of Learners of English" docx

... of variance of the ratio (Tanaka, 1977). Variance is calculated by (6)where denotes the number of samples used for calculating the ratio. Therefore, conﬁdence of the estimate of the conditional ... nouns. One of the reasons for the use of decision lists is that theyhave been shown to be effective to the word sensedisambiguation task and the mass count distinc-tion is highly related to ... is arguable what base of the log should be used.In this paper, it is set to 2 so that the effect of on the interpolated probability becomes large when the conﬁdence of the estimate of the conditionalprobability...

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