báo cáo khoa học: " The developing world in The New England Journal of Medicine" pps

... low-income countries among 111 editorial board members in five leading medical journals, including the Annals of Internal Medicine, BMJ, JAMA, the Lancet and the NEJM.Each of the five journals ... with the British Medical Journal (BMJ) and The Lancet providingfour times more coverage of diseases affecting primarilypoor countries than the New England Journal of Medicine(NEJM) or the Journal ... miscellaneous. If the title or abstract concerned a topic pertinent to anyhealth issue in the developing world, the article wasreviewed.Designation of a publication as pertaining to developing countries...

Tài liệu Báo cáo khoa học: An alternative isomerohydrolase in the retinal Muller cells of a cone-dominant species doc

... containing atRE in the presence of 1mM bipyridine (B) and liposomes containing atRE, in the presence of 1 mM bipyridine and 6 mM FeSO4(C). The generated retinoidswere analyzed by HPLC. The ... contribute toproviding chromophore to melanopsin to maintaintheir light sensitivities. The expression and function of RPE65c in other cell types in the retina remains to beinvestigated.Earlier ... RPE65c in the inner retina,including Mu¨ller cells, but not in the RPE. Furthermore, double-immuno-staining of dissociated retinal cells using antibodies for RPE65c and gluta-mine synthetase (a...

Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx

... residues directly involved in ligandbinding, presumably abolishing the interaction withsignaling partners. The remaining mutations alteramino acids located outside the ligand-binding pocketand ... pro-tein kinase B (PKB)]. In AKT, a cysteine substitution of the corresponding R25 in the pleckstrin homology(PH) domain also results in loss of function [16,17],thereby demonstrating related ... locations of the missense mutation in the BTK PH domain; arginine 28 is in dark blue, encircled in red. Bottom left: SH2 domain. Right: kinasedomain. The mutated residues are indicated in yellow,...

Tài liệu Báo cáo khoa học: Metabolic gene switching in the murine female heart parallels enhanced mitochondrial respiratory function in response to oxidative stress pdf

... reaction of the luciferin ⁄ luciferase mixture, energydonor (ATP) and oxygen results in the emission of light. The intensity of the bioluminescence was detected using aluminometer, and the mitochondrial ... McClain DA,Litwin SE et al. (2002) Insulin signaling coordinatelyM. F. Essop et al. Metabolic gene switching in murine female heartFEBS Journal 274 (2007) 5278–5284 ª 2007 The Authors Journal ... in fatty acid utilization,increase in glucose utilization) in the murine femaleheart. Moreover, our data suggest that these changesoccur in an Akt-independent manner. Further studiesare therefore...

Tài liệu Báo cáo khoa học: Osmosensing and signaling in the regulation of mammalian cell function docx

... integrin-dependentcell volume sensing and signaling integrates into the overall context of insulin signaling. Similarly, sensing of glutamine-induced hepatocyte swelling by integrinsfeeds into ... hepatocyte swelling [12,13], insu-lin-induced hepatocyte swelling is registrated by the integrin system, leading to a Src-dependent activation of the p38-type MAPK and thereby inhibition of autophagic ... outcome.This minireview summarizes recent progress in the understanding of howosmosensing and osmosignaling integrate into the overall context of growthfactor signaling and the execution of apoptotic...

Tài liệu Báo cáo khoa học: An intermediate step in the evolution of ATPases – a hybrid F0–V0 rotor in a bacterial Na+ F1F0 ATP synthase pdf

... the densities correspond to the N- andC-terminal helices of the c ring, respectively. The C-terminal helices show a clear handedness, and two of the rings face in the opposite direction in the membrane ... of the ion-binding site. Therefore, the c ring of A. woodii hasonly 10 membrane-buried negative charges that areessential for binding the ion and also for the rotationalmechanism of the ring. ... to the other two, forming the same patternas in the AFM surface representation of Fig. 2A. Bycomparison with the 3D structure of the I. tartaricusc ring [24], the black rings represent the...

Tài liệu Báo cáo khoa học: Bone morphogenetic proteins in the early development of zebraﬁsh pptx

... Follistatin, Chordin and Noggin[12]. These proteins are antagonists of BMP and othermembers of the TGF-b family, binding to and inhibit-ing these signaling molecules from binding to theirreceptors ... protein 2 in the early devel-opment of Xenopus laevis. Mech Dev 52, 357–370.7 Fainsod A, Steinbeisser H & De Robertis EM (1994)On the function of BMP-4 in patterning the marginalzone of the ... theirreceptors in the extracellular space, thus inhibiting ven-tralizing activities. Of these proteins, Chordin has along-range effect. In Xenopus, expression of the chordingene is localized to the dorsal...

Tài liệu Báo cáo khoa học: Integral membrane proteins in the mitochondrial outer membrane of Saccharomyces cerevisiae docx

... within the intermembrane space, and the proteolysis must therefore represent a loss of 2 kDafrom the N-terminus. Given there are seven arginineand lysine residues spread through the N-terminalstretch ... most of the proteincomponents are integral in the membrane, most of these mitochondrial pro-teins behave as if they have a-helical transmembrane domains, rather thanb-barrels. These proteins ... antibody recognizing the GFP tag at the C-terminus of Om14-GFP shows the electrophoreticmobility of the fusion protein is reduced, indicating a2 kDa mass difference. The C-terminal GFP epitopeis...

Tài liệu Báo cáo khoa học: "Automatic error detection in the Japanese learners’ English spoken data" pdf

... categories.Method C * there is telephone and the books on the desk. Eb: The word in the beginning of the part which should be replaced. Ee: The word in the middle or the end of the part which ... word and the one preceding/ the targeted word and the one following/ the targeted word and the two preceding/ the targeted word and the two fol-lowing), and the first and last letters of the word. ... i.e., the targeted word and the two preceding and follow-ing words, their word classes, their root forms, five combinations of these (the targeted word, the one preceding and one following/ the...

Tài liệu Báo cáo khoa học: "Reactive Content Selection in the Generation of Real-time Soccer Commentary" pdf

... development of the game situation. In the Figure 5, we have illus- trated this in the same way we did for the case of interruption. The left hand side of the solid line is lower than that of the ... that interruptions raise the importance score gain by reacting sharply to the sudden increase of the importance score. Abbreviation If the two most important propositions in the Pool are of ... basic input information on the positions of the ball and the players. An NL generator then selects contents from a large number of propositions describing these features. The selection of contents...

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