... (133 of 198) have anamino-terminal kinase domain, followed by a variablearray of ankyrin repeats (1 to 26 repeats, median of 8),whicharenotfoundinanycorekinases.Theyarealsoevolutionarily mobile, ... by phosphorylation andpolyglycylation of the C-terminal tail. J Biol Chem 2006, 281:5137-5148.45. Anamika K, Bhattacharya A, Srinivasan N: Analysis of the protein kinome of Entamoeba histolytica. ... below).Catalytically dead kinases In most kinomes, about 10% of kinases lack critical cata-lytic residues (K72, D166, D184) and are likely to be cat-alytically inactive, yet may retain signaling...