Báo cáo y học: " The utility of the Historical Clinical Risk -20 Scale as a predictor of outcomes in decisions to transfer patients from high to lower levels of security-A UK perspective" pptx

... that mea-sures such as the HCR-20 may have value in routine clinical decisions as they may assist in the assessment of those who are likely to succeed or fail on trial leaves to lower levels of ... status in patients mana-ged by community mentally health services in the UK [40], we examined its utility as an assessment tool in decisions to transfer patients from high to lower levels of ... Clinical Risk -20 Scale as a predictor of outcomes in decisions to transfer patients from high to lower levels of security -A UK perspectiveMairead Dolan1*, Regine Blattner2AbstractBackground:...

Báo cáo y học: "Too cold may not be so cool: spontaneous hypothermia as a marker of poor " ppt

... hyperthermia, instead of spontaneous hypothermia, as a result of hypothalamic damage [10]. is study may also help explain some recent clinical observations. In particular, it was recently shown that ... spontaneous hypothermia may have been a major confounding factor of these studies. While animal studies are conducted in stable condi tions, this may often not be the case in humans after CA. In ... body temp-era ture should therefore be included in the early assess-ment of comatose CA patients and will be an important variable to be taken into account in future studies.AbbreviationsAPACHE,...

Báo cáo y học: "Is Obesity Associated with an Increased Risk for Airway Hyperresponsiveness and Development of Asthma" pdf

... unit of BMIincrease was associated with an approximately 6% increase in asthma risk in women and a 3% increase in men. A stronger association between obesity and asthma wasobserved in non-allergic ... was used to assess the association betweencontinuous BMI and airway responsiveness. Two-wayANOVA was used to analyze means of grouped data, andleast-square means post hoc analysis using the ... and hence increased airways resistanceand methacholine reactivity. Therefore, obese patients complain of more dyspnea and asthma-like symptomsthan leaner patients and may be incorrectly diagnosedwith...

Báo cáo y học: "Inhibitory effects on HAV IRES-mediated translation and replication by a combination of amantadine and interferon-alpha" doc

... luciferase assays were performed using the Dual Luciferase assay system (Toyo Ink, Tokyo, Japan) according to the manufacturer’s instructions [2]. For controlling the variations in transcription, ... observation of the suppression of HAV IRES-mediated transl ation by amantadine and IFN-alpha. Sup-pression effects at 48 h after transfection by the combina-tion of amantadine and IFN-alpha against ... Y, Wu T:Amantadine as a regulator of internal ribosome entry site. ActaPharmacol Sin 2008, 29:1327-1333.8. El-Sabbagh OI, Rady HM: Synthesis of new acridines and hydrazonesderived from cyclic...

Báo cáo y học: "Protein, iron, and meat consumption and risk for rheumatoid arthritis: a prospective cohort study" pps

... onlyuntil the date of first symptom of RA, rather than until the date of RA diagnosis. We also performed lagged analyses suchthat the dietary intakes associated with RA cases wereassessed at least ... hazardsanalyses to calculate the rate ratio of RA associated with intakes of protein (total, animal, and vegetable) and iron (total, dietary, from supplements, and heme iron) and their primary foodsources, ... irregular) in 1982.Statistical analyses The number of person-years of follow up was ascertainedbased on the interval between the date of return of the 1980questionnaire and the date of diagnosis of...

Báo cáo y học: " Myeloid dendritic cells correlate with clinical response whereas plasmacytoid dendritic cells impact autoantibody development in rheumatoid arthritis patients treated with infliximab" pdf

... positive clinical response to infliximab therapy was defined as a drop in the DAS28 from baseline by >1.2 or as a DAS28 <3.2 at week14. In addition, 30 healthy blood donors were included in the study. ... pathophysiology of various human dis-eases, including autoimmune diseases [2]. In systemic lupuserythematosus (SLE), an autoimmune disease characterizedby the presence of an autoimmune reaction against ... <0.001) of the proportion of circulating plasma cells comparedwith RA ANA-negative patients (Figure 6a) . The percentage of plasma cells in RA ANA-positive patients was similar to thatobserved in...

Báo cáo y học: "Lassa virus-like particles displaying all major immunological determinants as a vaccine candidate for Lassa hemorrhagic fever" ppt

... surface by 48 hours, resulting in large areas of monolayer breakdown (Figure 2C). Cellu-lar cytotoxicity was measured by MTT assays, and chro-mosomal DNA fragmentation analysis was employed to determine ... licensure includeNovavax’s trivalent seasonal influe nza vaccine. In recentPhase II clinical trials the vaccine was well tolerated andsafe in adults age 60 and olde r and in healthy volunteers18 to ... represents a regula-tory advantage for this platf orm as a vaccine candidate.Administratio n of pseudoparticles containing autologousribosomes to vaccinees has potential to result in unto-ward immunological...

Báo cáo y học: " Amino acid residues that are important for Hyal2 function as a receptor for jaagsiekte sheep retrovirus" potx

... cell-surface proteinHyal2 as a receptor for cell entry [2]. Hyal2 is a member of a family of proteins, some of which exhibit high hyaluronidase activity and are capable of rapid degrada-tion of hyaluronan, ... levels are at least as high as those of human Hyal2 following expression plasmid transfection. Plasmids encoding amino-terminal Flag-tagged mouse or human Hyal2, or an empty plasmid as a con-trol, ... receptor activity of mouseHyal2 is due to the combined action of multiple aminoacid changes acting in concert.Interestingly, the mutation R301G increased the receptoractivity of human Hyal2 by...

Báo cáo y học: "Submersion, accidental hypothermia and cardiac arrest, mechanical chest compressions as a bridge to final treatment: a case report" doc

... Car-diopulmonary by-pass assistance was again considered,but still unavailable, why an IcyCath® catheter (AlsiusCorp., CA, USA) was placed in the femoral vein forrewarming and temperature control. ... circulation can only be spec-ulated on; one reason may be that his airway was securedat an earlier time than patient 1. The potential benefit of younger age in cases of accidental hypothermia and sub-mersion ... ventilation.Out -of- hospital intubation failed and he was intubatedon arrival in the emergency room (ER), approximately 40min after the accident. At this time, the patient still hadasystole and mechanical chest-compressions...

Báo cáo y học: "Membrane transporters and protein traffic networks differentially affecting metal tolerance: a genomic phenotyping study in yeas" potx

... and INO80,plus the histone deacetylase HDA1. Proteins involved in his-tone acetylation may affect metal tolerance by influencingDNA reactivity as well as DNA accessibility to repair enzymes,or ... for recycling hydrolasereceptors and other vacuolar traffic components from the PVC to the late Golgi and to the plasma membrane [77,80,81].Mutational inactivation of these pathways can lead, ... on the genes that are involved in these pathways. (b) Serial tenfold dilutions of mutant strains representative of pathway I and II assayed for their capacity to grow onto yeast extract-peptone-dextrose...

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