báo cáo khoa học: " Delivering the WISE (Whole Systems Informing Self-Management Engagement) training package in primary care: learning from formative evaluation" ppsx

... the WISE training package The aims of the training are outl ined in Table 1. The content of the training package was developed by TB,CCG, LG, AK, and JP, and the preliminary format for the training ... RESEARC H ARTIC LE Open Access Delivering the WISE (Whole Systems Informing Self-Management Engagement) training package in primary care: learning from formative evaluationAnne Kennedy*, ... 357:181-190.doi:10.1186/1748-5908-5-7Cite this article as: Kennedy et al.: Delivering the WISE (Whole Systems Informing Self-Management Engagement) training package in primary care: learning from formative evaluation. Implementation...

báo cáo khoa học: " Is untargeted educational outreach visiting delivered by pharmaceutical advisers effective in primary care? A pragmatic randomized controlled trial" pptx

... improvements in both the process and outcome ofcare [1]. They figure prominently within the UK, particu-larly since the inception of the Scottish IntercollegiateGuidelines Network (SIGN) and the National ... Estimates of the effect of the intervention on the prescribing of antidepressants assuming a constant difference between intervention and control practices in the year following the interventionDrug ... developed and used by the PCTs to markdata accordingly. A letter was sent to every GP in the dis-trict outlining the study, informing them that anony-mous, aggregated PACT data were being used for...

báo cáo khoa học: " Bridging the gap between systems biology and medicine" potx

... teams, the creation of centers ofexcellence in systems medicine and specific training programs, and enhancement of the attractiveness of amedical career for individuals with training in quantitativefields. ... defined, the new discipline of systems medicine is emerging as a translational extension of systems biology. How is systems medicinedefined? What are relevant ontologies for systems medicine? ... become a clinical reality within the next 5 to10 years [10]. The main problems involved in findingmarkers for personalized dosage are that each complexdisease may involve altered interactions...

báo cáo khoa học:" Assessing the Stroke-Specific Quality of Life for Outcome Measurement in Stroke Rehabilitation: Minimal Detectable Change and Clinically Important Difference" pdf

... when interpreting and generaliz-ing the study findings. First, the generalizability of the currentfindingsmightbelimited.Becauseweonlyincluded patients from departments of rehabilitationwith the ... receiving the intervention in these 2 randomized controlled trials, 74 completed the SS-QOL and were included in the present study. The second part of the study is related to MDC. Toobtain the ... toprovide further insights into the clinimetric propertiesof the SS-QOL in specific contexts.Finally, there are potential clinimetric differences in patient-reported QOL outcomes due to the modes...

Báo cáo khoa học: "Intraabdominal and retroperitoneal soft-tissue sarcomas - outcome of surgical treatment in primary and recurrent tumors" potx

... wereexcluded from the study. In the following, the termrecurrent disease refers to patients having their firstrecurrent disease unless otherwise stated. Variablesrelated to the pre-, p eri- ... are performed usinga fine needle because of the risk of spreading throughtumor seeding, also considering the puncture route[9,10]. The l iterature on o utcome in particular in recur-rent sarcomas ... wasnecessary in 48%, which is in the same order of magni-tude as in other reports [7], and radical surgery wa sachieved in 78%, also comparable to other centers [7]. Asexpected, in patients...

Báo cáo khoa học: "Impact of computerized physician order entry on medication prescription errors in the intensive care unit: a controlled cross-sectional trial"

... the clinical pharmacist, comprising 1,286 in the C-Uand 1,224 in the PB-U. In the C-U, 44 MPEs occurred versus331 in the PB-U (3.4% versus 27.0%, P < 0.001). Overall, the ICIS resulted in ... purposes)Competing interests The authors declare that they have no competing interests.Authors' contributionsAll of the authors were involved in designing the study. KC wasresponsible for conceiving ... medication ordering. These results areshown in Table 3. In the C-U, the minor MPEs were mainly wrong pharmaceuticalform errors and infusion rate errors. The intercepted MPEs par-ticularly involved...

Tài liệu Báo cáo khoa học: Seeking the determinants of the elusive functions of Sco proteins pptx

... close to the N-terminal trans-membrane helix anchoring the protein to the innermembrane of mitochondria [27]. Therefore, the N-ter-minal segment (containing the residues protruding into the mitochondrial ... heterogeneity involving, in addition to the metal-binding site region, also the b sheet and the sur-rounding a helices which constitute the protein core ofSco2 [28]. Cu(I) binding, however, is in both ... experimentally the roles of the duplicated proteins in kinetoplasts and land plants aswell. In particular, determining the function of the duplicated plant proteins would be especially interest-ing, as in...

Tài liệu Báo cáo khoa học: Resolving the native conformation ofEscherichia coli OmpA docx

... while the hydrophilic C-terminaldomain remains in the periplasm. Enzymatic attach-ment of OHBs to residues in this segment increasestheir hydrophobicity and thereby facilitates their inser-tion ... the C-terminaldomain that must traverse the bilayer to reach the extracellular aqueous medium. In the Stathopoulosmodel [32], the longest extracellular loop formed dur-ing the folding of the ... two-domain structure ofOmpA, in which the N-terminal domain (residues1–170) crosses the membrane eight times in antiparallelb-strands, and the 155-residue C-terminal domainresides in the periplasm,...

Tài liệu Báo cáo khoa học: Cobalamin uptake and reactivation occurs through speciﬁc protein interactions in the methionine synthase–methionine synthase reductase complex docx

... proportion of the FMN domain,converting some of the enzyme to the active form. The  3-fold increase in activity may arise from the bindingof the FMN domain to hMS facilitating binding ofAdoMet and ... cob(I)alamin from CH3-H4-folate, generating H4-folate and the methylcob(III)alamin form of MS. During primary turnover, the homocysteine-binding domain (dot-ted barrel) and the CH3-H4-folate ... quenching of flavin fluorescence, confirming thatthese two proteins do not interact with hMS. We havecompared the electrostatic potentials for the surface of the CPR FMN domain (in the region of the...

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