... of cell cultures, human plasma and in the cerebrospinal fluid. Other enzymes, b-andc-secretase,cleave APP at the N and C termini of Ab, respectively,releasing the amyloidogenic peptide [2,3].APP ... zinc-fingerdomain of PKCe was found to contain all of the informa-tion necessary for exclusive localization to the Golginetwork and that both the holoenzyme and its zinc fingerregion modulate Golgi function. ... increases formation from the trans-Golginetwork (TGN) of secretory vesicles containing APP,suggesting a role for PKC in the regulation of secretoryvesicle formation [34]. Furthermore Skovronsky and...