báo cáo khoa học: "Gene-expression and network-based analysis reveals a novel role for hsa-mir-9 and drug control over the p38 network in Glioblastoma Multiforme progression" ppsx
báo cáo khoa học: "Gene-expression and network-based analysis reveals a novel role for hsa-mir-9 and drug control over the p38 network in Glioblastoma Multiforme progression" ppsx
... Pathway Interaction Database (PID) [12]. We Gene-expression and network- based analysis reveals a novel role for hsa-mir-9 and drug control over the p38 network in Glioblastoma Multiforme progression ... MAPKAP kinases Tamoxifen ESR1 Signaling mediated by p38- alpha and p38- beta pathway Six out of the 69 drugs in The Cancer Genome Atlas (TCGA) clinical dataset that targets genes in the p38/ mapkap ... strengthen the hypothesis that miR-9 may indeed be a key regulator over pathway behavior and may serve as a potential therapeutic target for Glioblastoma patients. Drug target analysis Over the...
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báo cáo khoa học: " Polymeric nanoparticle-encapsulated curcumin ("nanocurcumin"): a novel strategy for human cancer therapy" ppsx
... used as a spice and coloring agent in Indian food, as well as a therapeutic agent in traditionalIndian medicine. Enthusiasm for curcumin as an anti-can-cer agent evolved based on the wealth ... - ravira@jhmi.edu; Collins Karikar - ckarika1@jhmi.edu; Amarnath Maitra - maitraan@yahoo.co .in; Anirban Maitra* - amaitra1@jhmi.edu* Corresponding author AbstractBackground: Curcumin, a yellow ... up in triplicates to deter-mine means and standard deviations.Colony assays in soft agarColony formation in soft agar was assessed for therapywith free curcumin and equivalent dosage of nanocurcu-Nanocurcumin...
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Tài liệu Báo cáo khoa học: Diol dehydratase-reactivating factor is a reactivase – evidence for multiple turnovers and subunit swapping with diol dehydratase pdf
... coenzyme analog lacking the ade-nine ring in the upper axial ligand; a model of damagedcofactors) for free adeninylpentylcobalamin (AdePeCbl)(an inactive coenzyme analog containing the adeninering ... the enzymeÆreactivase complex was formed in smallamounts from apoenzyme and the reactivase and not atall from the enzymeÆCN-Cbl complex and the reactivase(data not shown).Affinity of the reactivase for ... to cause a conformational changeof the enzyme, resulting in the release of adenine-lack-ing cobalamins, such as CN-Cbl and damaged cofac-tor. The fact that the relative efficiencies of metal...
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Báo cáo khoa học: Biochemical characterization of USP7 reveals post-translational modification sites and structural requirements for substrate processing and subcellular localization pptx
... indicate an important role for the C-terminal domain in catalysis. The compari-son between Ub-AMC and Ub-K-TAMRA, revealedmore pronounced differences in the catalytic efficiencyof the variants ... expression in mammalian cells hadan N-terminal 3XFLAG tag and a C-terminal Myc tag. USP7-FL con-structs used for proteomics analysis contained either N- or C-termi-nal CBP-Protein A tags separated ... M1 and E20, an alpha helix from there and up to amino acidG28, followed by a b-sheet starting at T36 and extend-ing to residue L49, and a larger helix including aminoacids A5 5 to R66. Based...
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Báo cáo khoa học: Transcriptome profiling analysis reveals multiple modulatory effects of Ginkgo biloba extract in the liver of rats on a high-fat diet pdf
... suggestingthat GBE50 prevented the harm caused by an HFD. In addition, we found no significant alterations in the levels of alanine aminotransferase, aspartate amino-transferase or creatinine kinase ... product that matches the standardized German product as EGb761. GBE50 isapproved by the China State Food and Drug Administra-tion (SFDA) and is used clinically in China. GBE50 con-tains > ... that fatty acid bio-synthesis was repressed and metabolism was enhanced in animals exposed to an HFD with GBE50. Genesinvolved in fatty acid biosynthesis, such as Acacb,Acbd6 (acyl-CoA-binding...
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báo cáo khoa học:" Evaluating oral health-related quality of life measure for children and preadolescents with temporomandibular disorder" potx
... patient values for almost all health states. Differences among the threestudy groups are substantially greater for the TTO datathan for the rank and VAS data. Furthermore, the TTOvalues for ... integrated the TTO study protocol,scoring administration, and the visual aid. The programpresented the standardized health states (including the patient’s health state) in r andom order and re ... imaginable health state’ and 0 for the ‘worst imaginable health state’. The respondent rates the desirability of each health state by placing its card atsome point along the scale. This VAS exercise...
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báo cáo khoa học: " Quantitative 1H NMR metabolomics reveals extensive metabolic reprogramming of primary and secondary metabolism in elicitor-treated opium poppy cell cultures" pptx
... than most aminoacids. The concentration of asparagine also increased in Pseudomonas syringae-infected tomato leaves, suggestingthat asparagine, and not glutamine is primarily involved in the ... a halotolerant-alanine betaine accumulating Plum-baginaceae. Plant Physiol Biochem 2003, 41:993-998.47. Rathinasabapathi B: Propionate, a source of beta-alanine, is aninhibitor of beta-alanine ... strategies ofprincipal component analysis (PCA) and orthogonal par-tial least-squares-discriminant analysis (OPLS-DA) wereused to extract and display the systematic variation in the datasets....
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Tài liệu Báo cáo khoa học: What makes biochemical networks tick? A graphical tool for the identification of oscillophores ppt
... the kinetic parameters t hat enable such oscillations. The mainresult of such an analysis is that oscillations arise if t heparameter k3is the l argest and the parameters k6 and k7are the ... values and a 3< 0 in the unstable steady state, oscillations can beobtained. Analysis of negative and positive subgraphs and comparison of their values gives rise to the estimation of the kinetic ... order in the same network, as was illustrated for the two examples in this paper. The network outside the former s ubgraphmay do away with the oscillophoretic potential of the subgraph or maintain...
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Tài liệu Báo cáo khoa học: "Acquiring Lexical Generalizations from Corpora: A Case Study for Diathesis Alternations" pdf
... empirically attested in corpus data. We automatically acquire alternating verbs from large balanced corpora by using partial- parsing methods and taxonomic information, and discuss how corpus data ... percentages are the aver- age of the judges' individual classifications. 399 Acquiring Lexical Generalizations from Corpora: A Case Study for Diathesis Alternations Maria Lapata School ... for the dative alternation and cause, spoil, afford and prescribe for the benefactive), and 12 can appear in either frame but do not alter- nate (e.g., appoint, fix, proclaim). For...
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Báo cáo khoa học: "Grammar Approximation by Representative Sublanguage: A New Model for Language Learning" potx
... 2007.c2007 Association for Computational LinguisticsGrammar Approximation by Representative Sublanguage: A New Model for Language LearningSmaranda MuresanInstitute for Advanced Computer ... propose a new language learning modelthat learns a syntactic-semantic grammarfrom a small number of natural languagestrings annotated with their semantics, alongwith basic assumptions about natural ... con-straints: one for semantic composition and one for ontology-based semantic interpretation. The partial ordering among nonterminals allows the ordering of the grammar rules, and thus facili-tates...
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