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báo cáo khoa học: " Environmental exposures and mutational patterns of cancer genomes" potx

báo cáo khoa học:

báo cáo khoa học: " Environmental exposures and mutational patterns of cancer genomes" potx

... cancer exemplify what type of information can be gained from cancer genome sequencing.© 2010 BioMed Central Ltd Environmental exposures and mutational patterns of cancer genomesGerd P Pfeifer*M ... understanding the initial exposures leading to DNA damage, repair and eventually to mutation of specic sequences within a cancer genome. Two recent studies of melanoma and small cell lung cancer ... Origins of human cancer e origins of human cancers have environmental and hereditary components. Germline mutations of tumor suppressor genes found in cancer predisposition syn-dromes...
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Tài liệu Báo cáo khoa học: Functional expression and mutational analysis of flavonol synthase from Citrus unshiu pptx

Tài liệu Báo cáo khoa học: Functional expression and mutational analysis of flavonol synthase from Citrus unshiu pptx

... gene, and the essence of most of the conserved amino acids hasbeen further substantiated by site-directed mutagenesis of FHT [7,9] and by documentation of ligand binding incrystalline DAOCS and ... functionally proved and the lability of substrate and product rule out any cocrys-tallization. The setting of a helices and b-strands causes verysimilar CD spectra for this class of enzymes [27–29], ... dioxygenases, particularly those of microbial or human origin, catalyze reactions of medicinal and industrial relevance, and their spatial organization and mode of action are under investigation....
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Báo cáo khoa học:

Báo cáo khoa học: "Comparing Automatic and Human Evaluation of NLG Systems" potx

... toquickly and cheaply evaluate the impact of newideas, algorithms, and data sets. BLEU and re-lated metrics work by comparing the output of anMT system to a set of reference (‘gold standard’)translations, ... communicative goal; and that corpus texts are often not of high enough qual-ity to form a realistic test.2.2 Automatic evaluation of generated textsin MT and SummarisationThe MT and document summarisation ... NLP, and were native speakers of En-glish. They were shown forecast texts from all thegenerators and from the corpus, and asked to scorethem on a scale of 0 to 5, for readability, clarityand...
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Báo cáo khoa học: Signaling pathways and preimplantation development of mammalian embryos potx

Báo cáo khoa học: Signaling pathways and preimplantation development of mammalian embryos potx

... Laboratory of Cell Differentiation and Apoptosis of Ministry of Education of China, Shanghai Jiao Tong University, ChinaAn embryo is a stage in the development of plants,invertebrate and vertebrate ... Transcripts of Wnt3a, -6, -7b, -9a and -10bhave been detected in blastocysts, and Wnt1 and -4,Sfrp1 and Dkk1 are highly expressed at this stage[37]. Receptors (Fz2, frizzled-2 and Fz4, frizzled-4),intracellular ... kinase)-1, -2, -5, and MAPK ⁄ ERK1 are detected in unfertilized eggs and blastocysts. Transcripts and the protein localiza-tion of p38-regulated and -activated kinase, p38MAPK, MK2 and hsp25 have...
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báo cáo khoa học: "Cellular transfer and AFM imaging of cancer cells using Bioimprint" pdf

... reflects the profile of the imagingtip rather than of the rupture.Further illustrating the range and variation of cell mor-phologies, and the potential effect the thick layer of poly-mer has ... physical and chemical approachmay yield a better understanding into cell functionality and mechanics.Artifacts in the form of bubbles caught trapped betweenthe cell and polymer and ripping of the ... depressions of varying sizes. (b) A 40 µm wide magnification of the membrane reveals two types of depressions; deep and wide (1) as well as more abundant smaller and shal-lower (2) pits.Journal of...
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báo cáo khoa học:

báo cáo khoa học: " DNA polymorphisms and haplotype patterns of transcription factors involved in barley endosperm development are associated with key agronomic traits" pot

... sequencing of thecandidate genes. HHG and AG participated in the design and coordination of the study, interpretation of the data and the development of themanuscript. All authors read and approved ... largenumber of markers and is therefore expensive and sta-tistically complex [3]. The number of markers to beemployed depends on the genome size and t he extent of LD along the chromosomes. In a candidate ... thousand-grain weight and explained 4.0% of thegenetic variance (Table 4). Haplotypes of the candidategene BPBF were significantly associated to crude proteincontent and starch content and...
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Báo cáo y học:

Báo cáo y học: " Environmental exposures and their genetic or environmental contribution to depression and fatigue: a twin study in Sri Lanka" potx

... history of depression was present in 11.1% of thesample (8.2% of men and 13.6 % of wome n, sex differ-ence: z = 4.98, p < 0.001). Abnormal fatigue was presentin 25.3% (21.4% of men and 28.6% of ... 10 of 10(standard of living, early school leaving, and life events)were associated with history of depression through theinfluence of nonshared environments (E) (Table 3, and for a summary of ... fourrisk factors and fatigue.Some specificity of environmental influences ondepression and fatigueThere w ere some similarities in that the exposures thatinflue nced fatigue and history of depression,...
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Tài liệu Báo cáo khoa học: Helix mobility and recognition function of the rat thyroid transcription factor 1 homeodomain – hints from 15N-NMR relaxation studies pdf

Tài liệu Báo cáo khoa học: Helix mobility and recognition function of the rat thyroid transcription factor 1 homeodomain – hints from 15N-NMR relaxation studies pdf

... dis-tribution of the energy between the overall tumbling and the internal mobility, and is indicative of thedegree of internal restraint of each15N–1H vectormotion. In Fig. 4, most of the points ... minima of J(0) and J(xN) and a significant maximum of J(0.87xH), and that emerges not only within helix III,but also over a large portion of the protein, from Phe8to Met56, including the loop and ... graph of R1, R2 and {1H}–15N NOE val-ues along the sequence of the TTF1 HD at 11.7 T and 286 K.Fig. S2. Plot of J(0.87xN)–J(0) correlation from15Nrelaxation measurements of the...
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Tài liệu Báo cáo khoa học: Purification and structural characterization of a D-amino acid-containing conopeptide, conomarphin, from Conus marmoreus docx

Tài liệu Báo cáo khoa học: Purification and structural characterization of a D-amino acid-containing conopeptide, conomarphin, from Conus marmoreus docx

... Pro, Val or Lys, c-carboxylation of Glu, glycosylation of Ser or Thr, bromination of Trp, sulfation of Tyr, cyclization of N-terminal Gln, and epimerization of several different residues. It ... structure of conomarphinwas similar to those of other conotoxin cDNAs. ThecDNA-encoded precursor of conomarphin consisted of a conserved M-superfamily signal peptide of 25 resi-dues, a proregion of ... +3hydrogenbonds for Asn11(CO)–Trp14(HN) and Ser12(CO)–Thr15(HN), and confirmed by the slow solventexchange kinetics of the amide protons of Trp14 and Thr15. The observation of two small3JHN-Hacou-pling...
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Tài liệu Báo cáo khoa học: The antibacterial and antifungal properties of trappin-2 (pre-elafin) do not depend on its protease inhibitory function pptx

Tài liệu Báo cáo khoa học: The antibacterial and antifungal properties of trappin-2 (pre-elafin) do not depend on its protease inhibitory function pptx

... Araujo Soares RM (2006)Secretion of serine peptidase by a clinical strain of Candida albicans: influence of growth conditions and cleavage of human serum proteins and extracellularmatrix components. ... effect of a 5 lm concentration of trappin-2towards C. albicans was time-dependent, reaching 92%after 6 h and 98% after 18 h (Fig. 5).Effect of NaCl and heparin on the antibacterial and antifungal ... nature of the molecule, as assessedfrom the salt and heparin dependence of the antimicro-bial and antifungal effects.ResultsAntimicrobial effects of recombinant wild-typetrappin-2 and trappin-2...
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