báo cáo khoa học: " Novel genes for QTc interval How much heritability is explained, and how much is left to find?" pdf

báo cáo khoa học: " Novel genes for QTc interval. How much heritability is explained, and how much is left to find?" pdf

... complex diseases. Nature 2009, 461:747-753.doi:10.1186/gm156Cite this article as: Jamshidi Y, et al.: Novel genes for QTc interval. How much heritability is explained, and how much is left to ﬁnd? ... Central Ltd Novel genes for QTc interval. How much heritability is explained, and how much is left to ﬁnd?Yalda Jamshidi*1,2, Ilja M Nolte3, Timothy D Spector2 and Harold Snieder*2,3R ... expression and which is related to a hereditary motor and sensory neuropathy (LITAF), and a DNA base-excision and repair gene (LIG3).QT interval risk modelGiven that the heritability of QTc is estimated...

Báo cáo khoa học: Novel strategy for protein production using a peptide tag derived from Bacillus thuringiensis Cry4Aa pptx

... proteinase and may also simplify the puriﬁcationsteps.Cry4Aa is a dipteran-speciﬁc Cry toxin produced byB. thuringiensis subspecies israelensis, and is a member ofthe larger-sized protoxin group. ... thuringiensis Cry4AaTohru Hayakawa1, Shinya Sato1,2, Shigehisa Iwamoto2, Shigeo Sudo2, Yoshiki Sakamoto1,Takaaki Yamashita1, Motoaki Uchida1, Kenji Matsushima1, Yohko Kashino1 and ... stan-dard or by using the densitometric scanning method with acooled CCD camera system (Ez-Capture; ATTO, Tokyo,Japan) and image analysis software (CS analyser ver. 3.0;ATTO, Tokyo, Japan).The insoluble...

Tài liệu Báo cáo khoa học: Novel aspects of heat shock factors: DNA recognition, chromatin modulation and gene expression ppt

... core histones is associatedwith heat shock. This is achieved by HSF1 and the his-tone deacetylases HDAC1 and HDAC2 [77]. In heat-shocked cells, HSF1 binds to HDAC1 and HDAC2, and their histone-deacetylase ... Rpd3-contain-ing histone–deacetylase complex, which deacetylateshistones to repress transcription, is also recruited to induced genes. It is possible that the opposing activitiesof histone acetylase and ... not sufﬁcient to elicit histone dis-placement, suggesting that histone eviction is modu-lated by factors that are not linked to elongatingpolymerase [55]. Recently, a candidate factor was iden-tiﬁed...

Báo cáo khoa học: "A Method for Relating Multiple Newspaper Articles by Using Graphs, and Its Application to Webcasting" pptx

... quantity of information available today makes it difficult to search for and understand the information that we want. If there are many related documents about a topic, it is important to capture ... various tools for parsing and visualizing threads are available. In Section 2, a directed graph structure for articles is defined, and the procedure for constructing a directed graph is described ... point" in the story of the articles. For example, the word "state" is the dif- ferentia word for dT, and is in its adjacent articles ds, dg, anddlo. This means that d7 is a starting...

Báo cáo khoa học: Structural basis for the interaction between dynein light chain 1 and the glutamate channel homolog GRINL1A docx

... important, are also expected to contribute to the binding afﬁnity, for example thosebetween T420 and the backbone atoms of H68, L429 and Y77 in strand b4, and between P431 and thealiphatic part of ... modelled complex is shown in pink and the DYNLL1 NMR ⁄ crystal structure is shown inblue. The GRINL1A VETREIGVGCDLLPS peptide is shown in green, and the nNOS ⁄ PAK1 peptides are shown in purple. ... have beenreported for a few DYNLL1–target peptide complexes,ranging from 0.6 to 1 lm for Bim and swallow to 3 lm for dynein intermediate chain, 10 lm for nNOS and 100 lm for PAK1 [22,27,28]....

Báo cáo khoa học: Structural requirements for Caenorhabditis elegans DcpS substrates based on ﬂuorescence and HPLC enzyme kinetic studies pdf

... central HIT motif is critical for catalysis [14,20]. This histidine is involvedin the formation of a covalent nucleotidyl phosphohist-idyl intermediate, the nucleophilic agent for thec-phosphate ... cerevisiae is required for responses to heat shock and genotoxic stress [25,31].The kinetic studies presented in this article provideinsight into the mechanism of interaction of MMG and TMG caps with ... elegans exists in ﬁve different iso-forms, with different afﬁnity to m7GpppG and m32,2,7GpppG [20,21]. Human and yeast DcpS caneffectively hydrolyze only the m7GpppG cap, and human DcpS...

Báo cáo khoa học: "Form function for the ‘I-214’ poplar merchantable stem (Populus × euramericana (Dode) Guinier cv cultivar ‘I-214’)" pdf

... Roda82 For H > e · HTOT+ f,S = d/(e · HTOT+ f – HTOT) · H + d/[1 – (e · HTOT+ f)/HTOT](8)where S is the cross sectional area at height H, G13 is thebasal area, HTOT is the total ... money.Acknowledgements: This work has been financed bythe Direction of rural areas and forests (Ministry ofAgriculture and Fishery of France). I especially wish to thank Christine Deleuze for her comments ... this height. The model sensitivity functions(figure 10) show that it is precisely in this zone above7.5 m, that it is necessary to get most measurements for the estimation of parameter d and...

Báo cáo khoa học: " Ipsilateral irradiation for well lateralized carcinomas of the oral cavity and oropharynx: results on tumor control and xerostomia" pot

... treatment for head and neck cancer patients, showing a high success rate in theearly stages of disease. However, permanent xerostomia is a common complication, frequently compromising nutri-tion and ... boththe head and neck surgeon and the radiation oncologist,endoscopy and CT scan of the head and neck region. Achest X-ray or chest CT and blood test were performed to rule out distant metastases. ... the same visit, 5 patients (31.2%) hadgrade 1 xerostomia and 9 patients (56.2%) had no xeros-tomia symptoms. Two patients (12.5%) showed grade 2xerostomia. No grade 3 subjective xerostomia was...

Báo cáo khoa hoc:" Alternative models for QTL detection in livestock. II. Likelihood approximations and sire marker genotype estimations" pot

... estimated.This is not important for an objective of QTL detection but shows the limit ofthis method, if an objective is to pursue QTL effect estimation simultaneously. For all ... marker map is known, A! is proportional to the joint likelihood ofquantitative and marker observations considering the hsi as random parameterswith uniform prior distribution, ... families when marker information is available on progeny, parents and grandparents was presented by Elsen et al. !2!.This likelihood is a two-level mixture distribution with different...

Báo cáo khoa hoc:" Alternative models for QTL detection in livestock. III. Heteroskedastic model and models corresponding to several distributions of the QTL effect" pps

... Dams are homozygous for this QTL. Under this hypothesis, thewithin offspring residual variance is lower for sires homozygous for this QTLthan for the heterozygous sire. ... simulations were performed in asimplified situation. A very informative marker, linked totally to the QTL wasassumed to exist, and the residual variance was assumed to be known ... asymptotic distribution of Fishertest statistic is the same if the residual variance used in the denominator is replaced by any consistent estimate of this variance....

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