báo cáo khoa học: " Staging of biliary atresia at diagnosis by molecular profiling of the liver" docx

... survival.Conclusions: Molecular profiling at diagnosis of biliary atresia uncovers a signature of inflammation or fibrosis in most livers. This signature may relate to staging of disease at diagnosis and ... that takeinto account the patient's biological makeup.ConclusionsGene expression profiling of the liver at the time of diag-nosis of biliary atresia identifies prominent signatures of inflammation ... model of cholestasis induced by bile duct ligation [35]. Molecular profiling of liver biopsies at the time of diag-nosis has been shown to differentiate the embryonic andperinatal forms of biliary...

Tài liệu Báo cáo khoa học: EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors docx

... and the phos-phorylation state of their proteins, thereby changing the amount and localization of Bcl-2 family members.However, each type of cancer has its own way of disrupting the balance of ... ‘Bcl-2-regulated’) pathway [20]. The intrinsic pathway is characterized by the permeabili-zation of the outer mitochondrial membrane and the release of several pro-apoptotic factors into the cytoplasm. ... inhibits the activation of the other two MAPKs, namely p38MAPK and c-Jun NH2-terminal kinase (JNK). Fur-thermore, the phosphatidylinositol 3-kinase (PI3K) ⁄Akt pathway, which is activated by the EGFR,...

Báo cáo khoa học: Nck-1 selectively modulates eIF2aSer51 phosphorylation by a subset of eIF2a-kinases docx

... 2007)doi:10.1111/j.1742-4658.2007.06110.xPhosphorylation of the a-subunit of the eukaryotic initiation factor 2(eIF2) on Ser51 is an early event associated with the down-regulation of protein synthesis at the level of translation and initiation ... translational factors regulating the initiation,elongation and termination of translation (reviewed in[1]). Translation initiation is by far the most complexand is driven in part by the eukaryotic ... suggests that the effect of Nck on the phosphorylation of eIF2aSer51 isindependent of the type of stress condition mediating the activation of eIF2a-kinases.Nck fails to alter GCN2-mediated eIF2aSer51phosphorylationTo...

báo cáo khoa học: "Leser-Trélat syndrome in patients affected by six multiple metachronous primitive cancers docx

... 2009. The patient’s sister had died of neck cancer at the age of 50 years. There wa s no history of malignanc ies in the patient’s mother, father or other first-degree relatives.Discussion The ... discussion of the manuscript; SS was supervisor of clinical management of the patient and interpretation of the data. Allauthors read and approved the final manuscript.Competing interests The authors ... keratosesare common findings, the early appearance of these ker-atoses and their eruptive nature are uncommon. How-ever, we believe that LTS is underestimated probablybecause of the lack of...

Báo cáo khoa học: "Using pig biliary system, in vivo propagation of Enterocytozoon bieneusi, an AIDS-related zoonotic pathogen" pps

... with the presence of spore in the biliary system. These results enable us toconclude that the biliary tree is an adequate niche for the propagation of E. bieneusi. The contribution of the hosts ... volume of phenol/chloroform. 300 ul of supernatant was then added to 50 ul of 5M NaCl and the mixture incubated for 10 min at 65oC. The solution wasthen extracted with an equal volume of chloroform ... observed at 72hours. On the other hand, The B cell proliferative activity of the normal animal dramatically increased at 72 hours,while those of the treated animals remained low level. Propagation...

Tài liệu Báo cáo khoa học: Hepatic stimulator substance mitigates hepatic cell injury through suppression of the mitochondrial permeability transition pdf

... investigated whetherHSS could function as an MPT inhibitor, thereby alle-viating hepatic injury and promoting the survival of hepatocytes, after transfection of HSS into the cells or the administration ... [12], the assembly of the apoptosome. Upon formation of this complex, caspase-9 acquires the ability to trigger the processing and activation of the downstream cas-pase cascade, which ultimately ... mitochondria of hepatocytes became depolarized 24 h after exposure toCCCP. Uncoupling may further lead to an impairmentin mitochondrial ATP formation and the hydrolysis of ATP by the uncoupler-stimulated...

Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): reactivity and structure of metal–thiolate clusters* doc

... concerning the size of the ion. Thus, the afﬁnity of the different metalions in MTs is governed primarily by the thermody-namic stability of the thiolate–metal bond. Therefore,soft metals ... discus-sion see below). The molecular basis of the air stability of the Cu(I)4cluster is not known. Cu(I)–thiolates arenormally oxidized by molecular oxygen, resulting in the formation of disulﬁde bonds ... just the result of the larger ionic radius of Cd(II)over Zn(II) and that the difference in amino acidsequence plays a role.One of the most important aspects is the greaterdynamics of the Cd(II)3-CysS9cluster...

Tài liệu Báo cáo khoa học: Simpliﬁed yet highly accurate enzyme kinetics for cases of low substrate concentrations ppt

... (ordissociation of C). In the second phase, both variablesevolve at similar rates towards their equilibrium values,corresponding to the consumption of substrate by the enzyme. The duration of the ... signiﬁcantly, the former better approx-imates a SIM than the latter, as demonstrated by the trajectories approaching it. When the enzyme concen-tration exceeds that of the substrate, the two manifoldsdiffer ... initialperiod, the evolution of the system is described by the part of the trajectory corresponding to the second, slowphase.A related feature of the model given by Eqns (2,3)(and one of central...

Tài liệu Báo cáo khoa học: Arabidopsis thaliana BTB⁄ POZ-MATH proteins interact with members of the ERF⁄AP2 transcription factor family ppt

... requires a completeMATH domain and the N-terminal region of RAP2.4 The use of a truncated version of BPM1 in the Y2Hscreens demonstrated that the BTB domain is notinvolved in the assembly with ... and in the anthers of dif-ferentiated ﬂowers. We also detected meagre expres-sion along the root, with most obvious stainingpresent at the lateral root primordia and the base of the lateral ... facilitate assembly withCUL3 and other BTB proteins [2,16], it remains unclearwhat kind of interactions are mediated by the MATHdomain in plants.In this article, we show that the MATH domain of BPM...

Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: therapeutic aspects of vascular endothelial growth factor doc

... [21], they showed that the VEGFR-1 expressed in motor neurons mediates the neuroprotective effect of VEGF-B. In addition, the administration of VEGF-B was reported toincrease the survival rate of ... vessels andtheir transfer to distant areas in the brain via bloodﬂow; (b) the rapid migration of tumor cells outsideblood vessels; and (c) the migration of tumor cellsindependent of the vascular ... are closely linked to the blood vessel system in the CNS. Therefore, thera-peutic strategies in the near future will be directlyrelated to the artiﬁcial manipulation of vessel struc-tures...

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