báo cáo khoa học: " The public health utility of genome-wide association study results for smoking behavior" docx

... testing of smoking will result in public health improvements [18] and reduce the likelihood of harm; such harm could include a lowering of the motivation to quit or of the self-efficacy for quitting, ... multiple risk variants and their interactions also may yield stronger associations for different smoking behaviors.Clinical validity of GWAS findings for smoking Because of their low penetrance and ... reveal the circumstances under which we can translate genetic insights into clinical practice in the hope of reducing the burden of smoking in society.© 2010 BioMed Central Ltd The public health...

báo cáo khoa học: " The global health governance of antimicrobial effectiveness" pot

... to public health the world over. Global health governance strategies need to address the erosion of antimicrobial effectiveness on three levels.Firstly, mechanisms to provide incentives for the ... 1 of 2(page number not for citation purposes)Globalization and Health Open AccessEditorial The global health governance of antimicrobial effectivenessGreg Martin*Address: London School of ... inappropriate choice of antimicrobial account for the bulk of resistant strainsemerging world wide. The WHO has taken the lead in thisregard with its recommendations under the 'widely andwisely'...

báo cáo khoa học: "The e-Health Implementation Toolkit: Qualitative evaluation across four European countries" ppt

... that. The practical side of e- health solutions is missing from the toolkit. Some of the questions leave a lot of room for interpretation and there are many questions in one question and then ... range of professionals for a range of different e -health systems. Users have to accept the need to do a bit of local adaptation and thinking about how best to use the toolkit—as they would before ... in the field of e -health specifically [13,18,19]. 27 Competing interests EM led the development of the e-HIT in a previous research project. The authors declare that they have no other...

Tài liệu Báo cáo khoa học: The tandemly repeated domains of a b-propeller phytase act synergistically to increase catalytic efﬁciency doc

... retained60% of the initial activity at 45 °C for 90 min whenassayed at 35 °C (Fig. 3A,B). The presence of Ca2+increased the thermal stability of PhyH and PhyH-DII.After incubation at 60 °C for 30 ... We focuson the function and relationship of the two singledomains. Additionally, the possibility that fusion of the PhyH N-terminal domain to other single-domain BPPswould improve the catalytic ... the capacity toincrease the catalytic efﬁciency of PhyH-DII. Further-more, the catalytic efﬁciency of PhyH was much greaterthan that of PhyH-DI and PhyH-DII combined (5.73fold) or twice the...

Tài liệu Báo cáo khoa học: The thioredoxin-independent isoform of chloroplastic glyceraldehyde-3-phosphate dehydrogenase is selectively regulated by glutathionylation docx

... oxidation.By contrast, the results of the present study showthat AnBnGAPDH isoforms, representing the majorisoforms of photosynthetic GAPDH in chloroplasts of higher plants, though being ... [20]. On the other hand, the activity of the puriﬁed recombinant C153S mutantwas similar to that of the wild-type protein (data notshown), and the kinetics of inactivation in the presence of 1 ... A8B8-GAP-DH. We examined the effect of these modiﬁcations on the enzyme activities, their reversibility in the presence of reductants, and the protective effect of the substrateBPGA and cofactors. Glutathionylation...

Tài liệu Báo cáo khóa học: The C-terminal domain of Escherichia coli Hfq increases the stability of the hexamer ppt

... position as that of the Sm-like SmAP3 of the archaea P. aerophilum [31] and, as in the case of SmAP3, the possibility of two conformations for the C-terminal domaincould not be excluded. The multiple ... another. The differencebetween the Hfqs results from the insertion of a fragment of variable length between the ﬁrst 67 amino acids and the end of the acidic C-terminal domain. Determining the ... destabilize the network of hydrogen bonds. The crystal structure of the ﬁrst 71 amino acids of E. coliHfq indicates that the C-terminal domain is probablylocated at the top of the ring, because the...

Tài liệu Báo cáo khoa học: "The grapho-phonological system of written French: Statistical analysis and empirical validation" pdf

... performance is influenced by the frequency of graphemic units in the language and by the predictability of their mapping to phonemes. We argue that these results implicate the availability of ... conversion. These findings are incompatible with current implementations of the dual-route theory (Coltheart et aL, 1993). The "central dogma" of this theory is that the performance of ... form is the idea that different GPC rules might have different strengths, with the strength of the correspondence being a function&apos ;of, for example, the proportion of words in which the...

Tài liệu Báo cáo khoa học: The isolation and characterization of cytochrome c nitrite reductase subunits (NrfA and NrfH) from Desulfovibrio desulfuricans ATCC 27774 Re-evaluation of the spectroscopic data and redox properties ppt

... member of the d-subdivision)were unsuccessful or led to the degradation of the isolatedspecies [10]; as a consequence, the stoichiometry of the complex was not established. The formation of stableNrfHA ... containing the double of NrfAsubunit in respect to the NrfH subunit. Nevertheless, insidethese huge aggregates there are species of the type a2b2. The present ﬁndings are in agreement with the ... degradation occurred. Therefore, thesesubunits require the presence of a detergent for stabilization.This behavior is typical of integral membrane proteins dueto the clustering of their hydrophobic...

Tài liệu Báo cáo khoa học: "The Structure and Process of Talking About Doing" pdf

... class="bi x0 y0 w1 h 1" alt ="" "point of view" for a problem solver at each point in the problem solving from a record of the problem solving report and a record of moves made. Then, ... model of the role of point of view in problem solving. SUMMARY We have reported here a three pronged approach to the study of problem solving action and report: I) the collected of data ... 2) development of a process model of these behaviors, and 3) use of coding techniques to extract traces of "critical phenomena" from the transcripts for evaluating the model. So far,...

Báo cáo khoa học: The N-terminal region of the bacterial DNA polymerase PolC features a pair of domains, both distantly related to domain V of the DNA polymerase III s subunit ppt

... test whether the removal of the second half of the PolC N-terminuswould help to improve the results further. Therefore,we took only the fragment of the multiple sequencealignment covering the ... did. After the iterative mod-eling procedure, the assessment results for the bestB. subtilis PolC-NI model were slightly worse than for the PolC-NII domain, yet comparable to those for the template ... (Table 1). Thus, the evaluation results suggestthat PolC-NI models are quite a reasonable approxi-mation of their native structure.Taken together, the modeling results reinforced the sequence-based...

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