báo cáo khoa học: " Metabolic adaptation of skeletal muscle to high altitude hypoxia: how new technologies could resolve the controversies" pdf
báo cáo khoa học: " Metabolic adaptation of skeletal muscle to high altitude hypoxia: how new technologies could resolve the controversies" pdf
... poiesis, Review Metabolic adaptation of skeletal muscle to high altitude hypoxia: how new technologies could resolve the controversiesAndrew J MurrayAddress: Department of Physiology, Development ... primarily on the metabolic response of skeletal muscle to hypoxia, it is essential that the adaptations discussed are placed firmly within the context of the whole organism, and therefore the information ... regarding the timings of such adaptations, the degree of the hypoxia in which they occur, and the tissue specificity of alterations in gene expression and metabolism. The emergence of new technologies...
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Tài liệu Báo cáo khoa học: Metabolic control of mitochondrial properties by adenine nucleotide translocator determines palmitoyl-CoA effects Implications for a mechanism linking obesity and type 2 diabetes pdf
... exertedby the proton leak. Similarly to the control of the ATPin⁄ ADPinratio, the distribution of the control of the ATPout⁄ ADPoutratio within the respiratory chaindepended on the substrate ... 68% of the decrease in Jo, 68% of the decrease in Jp, 56% of the increase in the QH2⁄ Qratio, 70% of the increase in Dw, 72% of the increasein the ATPin⁄ ADPinratio, and 59% of the ... established that the pri-mary cause of the effects of palmitoyl-CoA was inhibi-tion of the ANT. Assessment of the metabolic control of fluxes and intermediate concentrations by the ANTthen revealed...
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Báo cáo khoa học: Equilibrium distribution of skeletal actin–tropomyosin– troponin states, determined by pyrene–tropomyosin fluorescence potx
... fluores-cence. The complete change of pyrene–tropomyosinrequired the addition of nucleotide-free S1. Figure 6Bcompares the effect of both probes to the addition of S1 in the absence of Ca2+. Although the ... sensitivities of fluorescent probes to Ca2+have been used in the past to argue for the presence of an intermediate state of regulated actin. Because the probes can affect the behavior of the regulatory ... in the presence of Ca2+. The dashed lines are fits of the Hill model to the val-ues of light scattering data, and the predicted curvesfor p2 are shown as solid lines. The measured valuesof...
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Báo cáo khoa học: "Automatic Adaptation of Annotation Standards: Chinese Word Segmentation and POS Tagging – A Case Study" potx
... paper adopts the tag representation of Ng and Low (2004). For word segmentationonly, there are four boundary tags:• b: the begin of the word• m: the middle of the word• e: the end of the word• ... is attached to the tail of a boundary tag, to incorporate the wordboundary information and POS information to- gether. For example, b-NN indicates that the char-acter is the begin of a noun. ... Φ(x, y)·α denotes the inner product of fea-ture vector Φ(x, y) and the parameter vector α.Algorithm 1 depicts the pseudo code to tune the parameter vector α. In addition, the “averaged pa-rameters”...
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Báo cáo khoa học: "Domain Adaptation of Maximum Entropy Language Models" potx
... Then, we candecompose the prediction of a word given its his-tory into prediction of its class given the history,and prediction of the word given the history andits class :P (w|h) = P (C(w)|h)· ... small corpus of in-domain data. The main contribution of this∗Currently with Tallinn University of Technology, Esto-niapaper is that we show how the suggested hierar-chical adaptation can ... create two MEmodels: one corresponding to P (C(w)|h) and the other corresponding to P(w|h, C(w)). It is easy to see that computing the normalization factor of the first component model now requires...
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Báo cáo khoa học: Metabolic fate of L-lactaldehyde derived from an alternative L-rhamnose pathway ppt
... which isnot capable of growth on l-rhamnose [1]. Therefore, the acquisition of these l-rhamnose metabolic genes mighthave led to the appearance of LADH from a commonancestor of fungal ALDHs under ... (to S.W.), by the Research Foundationfrom the Association for the Progress of New Chemis-try (to S.W.), by the New Energy and Industrial Tech-nology Development Organization (to S.W.) and byCREST, ... from the concomitant activity of other constitutively expressed ALDH(s). Underanaerobic conditions, P. stipitis could metabolizel-rhamnose (data not shown). These results indicatethat the metabolic...
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Báo cáo khoa học: "Metabolic effects of phosphodiesterase III inhibitors: another reason to promote their use" pptx
... hyperglycemia, the degree of which is directly related to their specific β-receptor activity [18]. Given the hyperglycemia-related aggravation of oxidative stress,phosphodiesterase III inhibitors might ... enhances formation of reactive oxygenspecies [16], which in turn was shown to damage humanproximal tubular epithelial cells [17].In summary, a number of studies are now available showingthat, during ... an attractivealternative and/or adjunct to the use of catecholamines inpatients with low cardiac output.Competing interests The authors declare that they have no competing interests.References1....
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Tài liệu Báo cáo khoa học: Reversible tetramerization of human TK1 to the high catalytic efficient form is induced by pyrophosphate, in addition to tripolyphosphates, or high enzyme concentration ppt
... before the start of the reaction. During the first 15 min of the reaction, four samples of 10 lL each,taken at various time points 3, 6, 9 and 12 min after the start of the reaction, were applied to ... efficiency of ATP-incubated hTK1 is approximately 30-fold higherthan that of non-incubated hTK1. The two TK1 formscan therefore be referred to as the high- and low-efficiency forms. To explain the ... hTK1.In the present work, the part of the phosphatedonor that is necessary for the dimer–tetramer transi-tion of native hTK1 purified from human lymphocyteswas identified. Further, the effect of the...
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Tài liệu Báo cáo khoa học: Thermal unfolding of smooth muscle and nonmuscle tropomyosin a-homodimers with alternatively spliced exons docx
... [14]. The less stable of the twothermal transitions for skeletal Tm has been assigned to the C-terminal part of the molecule but the C-ter-minal region of the two Tms differ at exon 9 (and at the ... at most), yet the data inTable 1 shows that the total energy of unfolding of SmTm is 1.6-fold larger than that of Tm5a. The pro-portion of the total enthalpy in the three domains of each is very ... [5,39].Previous studies of thermal unfolding of skeletal Tmhave allowed assignment of the thermal transitions to specific regions of Tm for skeletal a-Tm [8,9,14]. Ther-mal unfolding of smTm (Fig. 3A)...
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Tài liệu Báo cáo khoa học: Thermodynamic analysis of porphyrin binding to Momordica charantia (bitter gourd) lectin pptx
... nointeraction w ith the p rotein [51]. On the other hand, the 3Dstructure of the H2TPPS–jacalin complex shows thatbinding of the same porphyrin to jacalin is mediated by acombination of hydrogen ... SwamySchool of Chemistry, University of Hyderabad, IndiaOwing to the use of porphyrins in photodynamic therapy for the treatment of malignant tumors, and the preferentialinteraction of le ctins ... investigated the interaction of several water-soluble porphyrins with MCL. The thermodynamic forces governing the interaction of some of the porphyrins have been delineated from ananalysis of the temperature...
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