... polymers of serpins, where the insertion of another molecule’s RCL takes place [8]. Both of theseresult in the irreversible inactivation (generally) of the serpins, and, in the case of the anticoagulant ... bottom of the inhibitor [6].In the process, the structure of the protease appears tobe deformed by being ‘crushed’ against the bottom of the inhibitor [7]. In particular, this deformation of the protease ... subsites in the active site of fXa [16,17], and the exposure of a newexosite on the serpin for interaction with the protease[18,19]. Given the plasma concentration of AT and the rates of interaction...