báo cáo khoa học: " Early activation of wheat polyamine biosynthesis during Fusarium head blight implicates putrescine as an inducer of trichothecene mycotoxin production" potx

... article as: Gardiner et al.: Early activation of wheat polyamine biosynthesis during Fusarium head blight implicates putrescine as an inducer of trichothecene mycotoxin production. BMC Plant Biology ... 10:289http://www.biomedcentral.com/1471-2229/10/289Page 2 of 13RESEARCH ARTICLE Open Access Early activation of wheat polyamine biosynthesis during Fusarium head blight implicates putrescine as an inducer of trichothecene mycotoxin productionDonald ... increases inthese polyamines were observed during the early sta ges of grain development in field grown wheat [35] and also during development of the rice panicle [36]. Putrescine is an inducer of...

báo cáo khoa học: "Brachypodium distachyon: a new pathosystem to study Fusarium head blight and other Fusarium diseases of wheat" pdf

... undertaking studies of Fusarium head blight and other Fusarium diseases of wheat. Keywords: Fusarium, Brachypodium distachyon, wheat, deoxynivalenol, model-to-crop translation, disease resistance,host-pathogen ... Steed1and Paul Nicholson1AbstractBackground: Fusarium species cause Fusarium head blight (FHB) and other important diseases of cereals. Thecausal agents produce trichothecene mycotoxins such as ... for FHB and other Fusarium diseases of wheat. Results: The ability of Fusarium graminearum and Fusarium culmorum to infect a range of Bd tissues was examinedin various bioassays which showed...

Báo cáo khoa học: Modelling and simulating interleukin-10 production and regulation by macrophages after stimulation with an immunomodulator of parasitic nematodes potx

... regulated in an autocrine fashion; (b) phospho-ERK is transient andphospho-P38 is sustained; (c) kinase deactivation is amore sensitive mechanism of feedback than phospha-tase activation; and (d) ... Germany2 Research Group Modeling of Biological Systems, German Cancer Research Center and BioQuant Center, Heidelberg, Germany3 Department of Parasitology, Berlin, Germany4 Institute of Pathology, ... (kinase deactivation).Model 2 assumes inhibition of ERK phosphorylationvia IL-10 (phosphatase activation) . Model 3 assumespromotion of ERK dephosphorylation via an inhibitor(kinase deactivation)....

Báo cáo y học: "Kbus/Idr, a mutant mouse strain with skeletal abnormalities and hypophosphatemia: Identification as an allele of ‘Hyp’" pdf

... mutantcould be important as a tool in further dissection andunderstanding of regulatory mechanisms of bone miner-alization and Pi homeostasis, and in assessment of ther-apeutic aspects of ... critical for regulation of bone matrix mineralization and phosphatehomeostasis. PHEX has been identified from analyses of human X-linked hypophosphatemic rickets and Hypmutant mouse models. We ... nesmany sinuses were observed even at 12 weeks of age;consequently, the long bones of Kbus adults had aderanged Haversian system and branched marrows, indi-cating defective vascularization and...

báo cáo khoa học: "Short-term salivary acetaldehyde increase due to direct exposure to alcoholic beverages as an additional cancer risk factor beyond ethanol metabolism" ppt

... framework of our function as governmental food and alcohol con-trol institution, which includes a chemical-toxicological as well as an organoleptical evaluation of products by atrained panel of assessors. ... alcohol consump-tion and the occurrence of malignant tumours of theoral cavity, p harynx, larynx, oesophagus, as well as of liver, colorectum, and female breast, so that ethanol inalcoholic beverages ... Nakamura C, Yokoyama T:Polymorphisms of alcohol dehydrogenase-1B and aldehydedehydrogenase-2 and the blood and salivary ethanol and acetaldehydeconcentrations of Japanese alcoholic men. Alcohol Clin...

Tài liệu Báo cáo khoa học: Synergistic activation of signalling to extracellular signal-regulated kinases 1 and 2 by epidermal growth factor and 4b-phorbol 12-myristate 13-acetate pptx

... Thus, as the local Sos concentration at the inner s urface of themembrane decreases, Ras activation is impaired as well as subsequent activation of downstream signalling m oleculessuch as ERK ... membrane, which causes the activation of Ras by exchanging GDP, bound to Ras, for GTP [11–13].Ras-GTP can bind cytoplasmic Raf1 leading to itsCorrespondence to J. Lankelma, Department of Molecular ... tandard error of the mean.3910 J. J. Hornberg et al. (Eur. J. Biochem. 271) Ó FEBS 2004phosphorylation and activation. Although R af1 c an bephosphorylated by many kinases, the exact mechanism...

Báo cáo khoa học: Proteolytic activation and function of the cytokine Spatzle in the innate immune response of a lepidopteran insect, Manduca sexta ppt

... observed0.1Aa_Spz4Ag_Spz4Dm_Spz4Nv_XP00160530771885979941004910086100905310099100337747288154994894Aa_Spz3Dm_Spz3Ag_Spz3Aa_Spz2Ag_Spz2Dm_Spz2Dm_Spz6Aa_Spz6Ag_Spz6Aa_Spz5Ag_Spz5Dm_Spz5Ms_Spz1ABm_Spz1Dm_Spz1AAa_Spz1ANv_XP001607462Nv_XP001599503Nv_XP001606369Tc_GLEAN06726Tc_GLEAN05940Tc_GLEAN13304Tc_GLEAN16368Tc_GLEAN01054Spz4 branchSpz3 branchSpz2 branchSpz6 branchSpz5 branchSpz1 branch86Fig. 3. Phylogenetic analysis of the cystine-knot ... D. melanogas-ter. The enhanced expression of proSpa¨tzle during an infection may lead to an increased ability to stimulatethe production of antimicrobial peptides during an infection, as a ... FEBSProteolytic activation and function of the cytokine Spa¨tzlein the innate immune response of a lepidopteran insect,Manduca sextaChunju An 1, Haobo Jiang2and Michael R. Kanost11 Department of...

Báo cáo khoa học: Covalent activation of heart AMP-activated protein kinase in response to physiological concentrations of long-chain fatty acids docx

... decrease inmalonyl-CoA sufﬁcient to allow activation of CPT1, inwhich case an early decrease in ACC activity (and/or an increase in MCD activity) is also required. We have nowshown that this can ... adominance of the fatty acid-driven pathway for activation of AMPK over at least some aspects of insulin signalling.This dominance of the fatty acid effect on AMPK activityprovides an explanation ... ratio of 2.7 : 1 and observed rates of fattyacid utilization of between 63 and 59 lmolÆh)1per g dryweight through an initial ÔpulseÕ and subsequent ÔchaseÕperiod.TheextentofactivationoftheAMPKwith0.5mMpalmitate...

Báo cáo khoa học: Sustained activation of ERK1/2 by NGF induces microRNA-221 and 222 in PC12 cells pdf

... and analyzed by immunoblotting. Anti-HA(3F10) rat monoclonal IgG was purchased from Roche(Basel, Switzerland). Anti-p44 ⁄ 42 MAP kinase, anti-phos-pho-p44 ⁄ 42 MAP kinase IgGs (numbers 9101 and ... Germany). As an internal control, a renilla luciferase vector pGL4.70 (Pro-mega) was used. The data represent means and standarddeviations of three independent experiments.Statistical analysisThe ... 2009)doi:10.1111/j.1742-4658.2009.07041.xMicroRNAs (miRNAs) are small non-coding RNAs that regulate geneexpression by inhibiting translation and ⁄ or inducing degradation of targetmRNAs, and they play important roles in a wide variety of...

Báo cáo khoa học: The activation of gelsolin by low pH The calcium latch is sensitive to calcium but not pH docx

... tested the binding of G4–6with G-actin by ELISA and fluorescence. G-actin wascoated onto plastic and increasing concentrations of G4–6(between 0 and 0.6 lM) were added. Binding was monitoredby ... G2domain was also observed. As shown in Fig. 5, an enhancement of tryptophan fluorescence was observedwhen the pH value increased from 5.8 to 6.5. A small red-shift (about 4 nm) was also linked ... was incubated with increasingconcentrations of G-actin (between 0 and 0.2 lM)andthechanges in fluorescence were monitored. Saturation curveswere observed in the presence of calcium and an...

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