Báo cáo y học: "Activity of the cyclooxygenase 2-prostaglandin-E prostanoid receptor pathway in mice exposed to house dust mite aeroallergens, and impact of exogenous prostaglandin E" pot
Báo cáo y học: "Activity of the cyclooxygenase 2-prostaglandin-E prostanoid receptor pathway in mice exposed to house dust mite aeroallergens, and impact of exogenous prostaglandin E" pot
... pre-clinical settings, and has encour-aged investigators to further analyze the underlying mech-anisms in vitro and in vivo [7-9]. The roles of endogenousPGE2 and of fluctuations in cyclooxygenase ... receptor (PGE2 receptor) expression shown in vitro[21,22], may have a profound impact on the ability of exogenous PGE2 to modulate the murine airway response to HDM. The EP3 receptor may ... airway inflammation. The mechanisms are unknown,but fluctuations of the endogenous cyclooxygenase (COX)-2 /prostaglandin/ E prostanoid (EP) receptor pathway activity likely contribute to the clinical...
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Báo cáo Y học: Effect of the disease-causing mutations identified in human ribonuclease (RNase) H2 on the activities and stabilities of yeast RNase H2 and archaeal RNase HII pot
... of the protein withoutseriously affecting the substrate binding affinity.Binding analyses using BIAcore system To examine whether the mutation of Gly10 to Leu orPro affects the substrate binding ... as a single polypeptide, we wereable to gain more insight into the effects of the glycineresidue near the active site of the protein. We showedthat the mutation of the conserved glycine residue ... calculated by van’t Hoff analysis. The difference in the free energy change of unfoldingbetween the wild-type and mutant proteins at the Tm of the wild-type protein (DDGm) was estimated by the relationship,DDGm=...
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Báo cáo y học: "Osteoradionecrosis of the cervical spine presenting with quadriplegia in a patient previously treated with radiotherapy for laryngeal cancer: a case report" docx
... consisted of stripping of the vocal cord and afull course of postoperative external beam radiotherapyfor 30 treatments in 43 days - right and left lateral wedgedfields totalling 6600cGy to the larynx ... Osteoradionecrosis of the hyoid presenting as a cause of intractable neck pain followingradiotherapy and the role of magnetic resonance imagescanning to aid diagnosis. J Laryngol Otol 2003, 117:1003-1005.9. ... and severelaryngeal scarring, a total laryngectomy was performed in February 2000. Histology showed no malignancy and the specimen showed changes consistent with post-radiotherapy change.In...
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Báo cáo y học: " Deletion of the meq gene significantly decreases immunosuppression in chickens caused by pathogenic marek’s disease virus" pptx
... pp38 isinvolved in early cytolytic infection of lymphocytes, butnot the induction of tumors [11]. Recently studiesshowed that the mechanism of attenuation of MDVdoes not involve the 132 bp repeat ... bursa to the whole body weredeter mined [4]. Bursa and thymus of the surviv ing birds of each group were collected on days 28 p.i. and fixed in buffered 10% formalin, embedded in paraffin, and ... stained with hematoxy-lin-eosin for histopathological evaluation.Experiment 4 The effects of bac-GX0101 and GX0101ΔMeq on someblood parameters including erythrocytes, leukocytes and lymphocytes...
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Báo cáo y học: "Expression of the α7 nicotinic acetylcholine receptor in human lung cells" pdf
... receptor, it was necessary to showif expression of the α7 nicotinic acetylcholine receptor protein in seen in these cell lines. Using a specific anti-body for the α7 nicotinic acetylcholine receptor ... nitrosamine, 4(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), is a high affinity agonist for the α7nicotinic acetylcholine receptor (α7 nAChR) [5]. Binding of NNK to this receptor caused an influx ... permeability for Ca2+ [1-8]. Binding of agonists to this receptor activates the release of the autocrine growth factor serotonin [2-6]. In addi-tion, we have shown that the nicotine-derived carcino-genic...
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Báo cáo y học: "Mechanism of the chromosome-induced polar body extrusion in mouse eggs" potx
... formation and cortical actomyosin assembly into special cap and ring structures in the cortex of the oocyte. The spindle and the cortical cap/ring interact to generatemechanical forces, leading to ... mitosis and meiosis withregard to the ability of the anaphase spindle midzone to induce cytokinetic furrows. It seems that the furrow-inducing ability by the sp indle midzone is restricted in the ... and interestingl y, after washing out of Lat-A, the myosin I Icaps were reorganized into rings again (data not shown).This suggests that the chromosome-induced actomyosincap and ring are interchangeable...
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Báo cáo y học: "Comparison of the oxidative phosphorylation (OXPHOS) nuclear genes in the genomes of Drosophila melanogaster, Drosophila pseudoobscura and Anopheles gambiae" docx
... surely allow abetter understanding of the evolutionary history of a set of genes that control a basic biological function, and also offerinteresting insights into the mechanisms of their coordinatedexpression. ... distribu-tion, ranging from hundreds to thousands of base-pairs [30-32]. Of the introns that interrupt the coding sequence in the 78OXPHOS genes investigated in the present study, 88 (64.7%) of 136 in D. ... detailed in Table 2. With the exception of one of the paralogs of the A.gambiae gene encoding ubiquinol-cytochrome c reductasecore protein 1, in all cases the search found the number of ESTs originating...
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báo cáo hóa học:" Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone" pptx
... paracrine and autocrine mechanisms, the secreted VEGF activates the VEGF-Flt-1-FAK pathway. The activation of this signaling pathway might beinvolved in the migration of these cells into the lesion ... of pY-Flt-1 and pY-FAK in GCT samples, the staining intensity of each specimen was scored as follows: 1 (weak staining; less than10% of the cells were positive cells), 2 (intermediate staining; ... 5b). These results sug-gest that VEGF binding to its receptor, Flt-1, on mono-cyte-like cells may induce the tyrosine phosphorylation of FAK in cells within GCTs.Correlation between the clinical...
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báo cáo hóa học:" Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone" potx
... mono-cyte-like cells may induce the tyrosine phosphorylation of FAK in cells within GCTs.Correlation between the clinical stage and pY-Flt-1 and pY-FAK expression in GCTs To determine the biological ... streptavidin. The signals were detected using 3-amino-9-ethylcarbazole in N,N-dimethylformamide. To examine the pY-Flt-1 and pY-FAK levels in GCT samples, the staining intensity of each specimen ... mechanisms, the secreted VEGF activates the VEGF-Flt-1-FAK pathway. The activation of this signaling pathway might beinvolved in the migration of these cells into the lesion at the site of bone...
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Tài liệu Báo cáo Y học: Analyses of the CYP11B gene family in the guinea pig suggest the existence of a primordial CYP11B gene with aldosterone synthase activity docx
... the proteins of the CYP11Bsubfamily catalysing the last biosynthetic steps are the keyenzymes for the synthesis of both mineralocorticoids and glucocorticoids.From molecular cloning of the corresponding ... decrease in the activityfor the 11b-hydroxylase, CYP11B1. Intriguingly, however, the 11b-hydroxylase activity of the aldosterone synthaseCYP11B2 was basically unaffected whereas the 18-hydroxy-lation ... protein adrenodoxin indicate dif-ferential sensitivity of CYP11B1 and CYP11B2 as well as the three hydroxylation steps catalysed by CYP11B2 to the availability of reducing equivalents. Together,...
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