... dendritic cell activation and systemic autoimmunity. Immunity 2003,19:437-450.50. Lu Q, Lemke G: Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family. Science2001, ... splenocytesubsets and kidneys of MRL/lpr mice, suggesting that the typeII IFN pathway rather than the IFN-I pathway plays the domi-nant pathogenic role in the development of autoimmunity inthis ... drive the full activation of these cellsto differentiate into isotype-switched IgG-secreting plasmacells. On the other hand, by inhibiting the IFN-I response fur-ther upstream through the IFNAR2...