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Báo cáo y học: "Parthenolide inhibits ERK and AP-1 which are dysregulated and contribute to excessive IL-8 expression and secretion in Cystic Fibrosis cells" pdf

Báo cáo y học:

Báo cáo y học: "Parthenolide inhibits ERK and AP-1 which are dysregulated and contribute to excessive IL-8 expression and secretion in Cystic Fibrosis cells" ppsx

... pretreatment results in an inhibition of inflammatory signaling in cells with CF defects. Production of IL-8 and other pro-inflammatory cytokines is also governed by mechanisms regulating in their mRNA ... extracellular-regulated protein kinase (ERK) cascades are active by phosphorylation through dual specificity MAPK kinases (MKK) and may all contribute to IL-8 expression. We found no difference in baseline ERK- phosphorylation ... parthenolide inhibits inflammation in CF both in vivo and in vitro by inhibiting IKK/NFκB pathway. Parthenolide has been considered by some to be a specific inhibitor of the NFκB pathway [34-39]. During...
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Báo cáo khoa học: cAMP inhibits CSF-1-stimulated tyrosine phosphorylation but augments CSF-1R-mediated macrophage differentiation and ERK activation potx

Báo cáo khoa học: cAMP inhibits CSF-1-stimulated tyrosine phosphorylation but augments CSF-1R-mediated macrophage differentiation and ERK activation potx

... Epac,may instead activate a tyrosine phosphatase which results in the observed decrease in both basal and CSF-1-induced tyrosine phosphorylation. In contrast to the data for EGFR-dependent tyro-sine ... monocyte DNA synthesis by colony-stimulatingfactors, cytokines, and cyclic adenosine monophosphate.Blood 79, 1972–1981.9 Vairo G, Argyriou S, Bordun AM, Whitty G & Hamil-ton JA (1990) Inhibition ... surprisingly, thatinstead of there being more tyrosine phosphorylationthere was in fact a reduction in the degree of tyrosinephosphorylation of CSF-1R and that was found gener-ally in whole...
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Báo cáo y học: "TNF inhibits production of stromal cell-derived factor 1 by bone stromal cells and increases osteoclast precursor mobilization from bone marrow to peripheral blood" ppt

... bonemarrow cavity in chronic inflammatory arthritis.IntroductionTNF is a clinically validated etiological factor in inflammatory-erosive arthritis and is known to synergize with RANKL and macrophage ... in inflammatoryosteolysis. Arthritis Res Ther 2006, 8:201.2. Boyce BF, Schwarz EM, Xing L: Osteoclast precursors:cytokine-stimulated immunomodulators of inflammatory bonedisease. Curr Opin ... colony-stimulating factor (M-CSF) for 3 days to generate osteoclast precursors (OCPs). Cells were stained with allophy-cocyanin-labeled anti-CD11b and Phycoerythrin-labeled anti-Gr-1 antibodies and...
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Báo cáo y học: "Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling" ppsx

... F, Ficheux H, Pujol JP: Rhein inhibits interleukin-1 beta-induced activation of MEK /ERK pathway and DNA binding of NF-kappa B and AP-1 in chondro-cytes cultured in hypoxia: a potential mechanism ... growthfactors, cytokines, proteases, and inflammatory mediators. Thelevels of alkaline phosphatase, osteocalcin, type I collagen,interleukin (IL)-6, transforming growth factor-beta, prostaglan-din ... Canada)containing hydroxide peroxide. Slides were counterstainedwith hematoxylin/eosin.The staining specificity of the antibody used was determinedusing three controls according to the same...
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Báo cáo y học:

Báo cáo y học: "Aciculatin inhibits lipopolysaccharide-mediated inducible nitric oxide synthase and cyclooxygenase-2 expression via suppressing NF-B and JNK/p38 MAPK activation pathways" pot

... signals in macrophages [7]. The two pro-inflammatory enzymes, induciblenitricoxidesynthase(iNOS) and cyclooxygenase-2 (COX-2), which can beinduced by LPS or cytokines, are found to work in concert in ... the production ofinflammatory cytokines, chemokines, and proinflamma-tory enzymes (e.g. iNOS and COX-2) [38-40]. The pro-moter of the iNOS and COX-2 genes are known to contain two transcriptional ... modulation by curcumin and pyrrolidine dithiocarbamate ofthe UVB-induced cytokine expression by keratinocytes. Cytokine 2002,18:168-177.42. Lowenstein CJ, Alley EW, Raval P, Snowman AM, Snyder SH,...
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Báo cáo y học: " A Dietary Supplement Containing Standardized Phaseolus vulgaris Extract Influences Body Composition of Overweight Men and Women"

... prepared using heated processing conditions to substantially inactivate hemagglutinat-ing activity (HA) and trypsin inhibiting activity (TIA) while preserving alpha-amylase inhibiting ability. ... to follow the nutritionist’s recommendations. The candidates were entered into a 2-week single-blinded, run -in to en-rollment and randomization. Subjects in this run -in period unknowingly ... effects. Statistical Analysis To minimize differences in beginning values be-tween subjects, they were stratified into two groups very similar in size, age, gender, and body weight dis-tribution....
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Báo cáo y học:

Báo cáo y học: "Grb2-associated binder 1 polymorphism was associated with the risk of Helicobactor pylori infection and gastric atrophy"

... simultaneously in a specific orientation, in which Tyr-627 binds to the N-SH2 domain and Tyr-659 binds to the C-SH2 domain [17]. Experiments with Gab1 mutants which are unable to bind to SHP-2 indicate ... bisphosphoryl tyrosine-based activation motif (BTAM) that binds to and activates SHP-2 [17]. Two SH2 domaines of SHP-2, termed N-SH2 and C-SH2 domaines, are arranged in tandem at the amino (N)-terminal ... PTPase activity that can be activated by deletion of N-SH2 or both SH2 domains or by specific phosphopeptides that bind to the SH2 domains. The tandem SH2 domains bind to Tyr-627 and Tyr-659 simultaneously...
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Tài liệu Báo cáo Y học: A novel meta-cleavage dioxygenase that cleaves a carboxyl-groupsubstituted 2-aminophenol Purification and characterization of 4-amino-3-hydroxybenzoate 2,3-dioxygenase from Bordetella sp. strain 10d doc

Tài liệu Báo cáo Y học: A novel meta-cleavage dioxygenase that cleaves a carboxyl-groupsubstituted 2-aminophenol Purification and characterization of 4-amino-3-hydroxybenzoate 2,3-dioxygenase from Bordetella sp. strain 10d doc

... nitrogen and energy source. 4-Amino-3-hydroxybenzoic acid was meta-bolized via 2-amino-5-carboxymuconic 6-semialdehyde to 2-hydroxymuconic 6-semialdehyde by Bordetella sp. strain10d (Fig. 4A, and ... 4-amino-3-hydroxybenzoate cleavage. I,4-amino-3-hydroxybenzoic acid; II, 2-amino-5-carboxymuconic6-semialdehyde; III, 2-hydroxymuconic 6-semialdehyde; IV, 2,5-pyridinedicarboxylic acid. (B) Pathway ... freshlyprepared and used immediately.Effect of various compounds on the enzyme activityThe effect of metal salts, and chelating and sulfhydrylagents, on the enzyme activity with 4-amino-3-hydroxy-benzoic...
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Báo cáo khoa học: Rotenone inhibits mammalian cell proliferation by inhibiting microtubule assembly through tubulin binding Pallavi Srivastava and Dulal Panda ppt

Báo cáo khoa học: Rotenone inhibits mammalian cell proliferation by inhibiting microtubule assembly through tubulin binding Pallavi Srivastava and Dulal Panda ppt

... microtubules in vitro. It also inhibited the binding ofcolchicine to tubulin, perturbed the secondary structure of tubulin, and reduced the intrinsic tryptophan fluorescence of tubulin and the extrinsicfluorescence ... cellviability probes compatible with fixation and permeabi-lization for combined surface and intracellular staining in flow cytometry. Cytometry 19, 243–255.23 Rathinasamy K & Panda D (2006) ... beno-myl inhibits brain microtubule polymerization and dynamics and cancer cell proliferation at mitosis bybinding to a novel site in tubulin. Biochemistry 43,6645–6655.31 Amon A (1999) The spindle...
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