Báo cáo y học: "Suppression of nitric oxide production from nasal fibroblasts by metabolized clarithromycin in vitro" pptx
Báo cáo y học: "Suppression of nitric oxide production from nasal fibroblasts by metabolized clarithromycin in vitro" pptx
... 7:56http://www.journal-inflammation.com/content/7/1/56Page 6 of 12RESEA R C H Open AccessSuppression of nitric oxide production from nasal fibroblasts by metabolized clarithromycin in vitroAyako Furuya1, ... as: Furuya et al.: Suppression of nitric oxide production from nasal fibroblasts by metabolized clarithromycin in vitro. Journal of Inflammation 2010 7:56.Submit your next manuscript to BioMed ... theinhibition of TGF-beta signaling in lung fibroblasts. Respir Res 2006,7:16-29.13. Tayler BS, Geller DA: Regulation of the inducible nitric oxide synthase(iNOS) gene. In Nitric oxide and inflammation....
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Báo cáo y học: "Suppression of nitric oxide production from nasal fibroblasts by metabolized clarithromycin in vitro" potx
... 7:56http://www.journal-inflammation.com/content/7/1/56Page 6 of 12RESEA R C H Open AccessSuppression of nitric oxide production from nasal fibroblasts by metabolized clarithromycin in vitroAyako Furuya1, ... subjects.Assay for inducible NO synthases (iNOS)The iNOS levels in cytosol were assayed by commer-cially available human iNOS ELISA kits (R & D Systems,Inc., Minneapolis , MN) that contained sufficientreagents, ... synthetized from CAM cause a decrease in iNOS expression in cytosol after inflammatory stimu-lation, inhibiting superoxide generation and resulting in prevention of tissue injury in patients...
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Báo cáo y học: "Involvement of nitric oxide (NO) in cough reflex sensitivity between non-sensitized and OVA-sensitized guinea pigs" pptx
... sensitivity in non-sensitized guinea pigs and OVA-induced increase in cough reflex sensitivity in sensitized guinea pigs; however,iNOS inhibition caused by ONO1714 partially suppressed the OVA-induced ... needed to clarify the precise mechanism.Background Nitric oxide (NO) may p lay an essential role in regula t-ing airway funct ion and in the pathophysiology of inflammatory airway dise ases [1]. ... sensitivity induced by allergic reaction. However, the pathway of involvementis too complex to be explained by the results of the pre-sent study. The precise mechanism of action need to beinvestigated...
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Báo cáo y học: " Preparation of RGD-modified Long Circulating Liposome Loading Matrine, and its in vitro Anti-cancer Effects"
... reconstitutes in solvent. Because matrine is a strongly hydrophilic and weakly alkaline drug, the encapsulation efficiency of liposomes for loading matrine is very low when pre-pared by routine ... freeze-drying, was separated by mini-gel columns of Sephadex-G50 prepared in advance. In brief, incubation mixtures of 200μL containing unloaded matrine and RGD-M-LCL were added onto mini-gel ... the use of this material could augment the effects of matrine on cancer cells in vitro. Key words: Matrine, Liposomes, Cyclic arginine- glycine-aspartic acid, Drug delivery systems. Introduction...
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Báo cáo y học: "Effect of increasing intraperitoneal infusion rates on bupropion hydrochloride-induced seizures in mice" pptx
... miceThe IP administration of bupropion HCl 120 mg/kg by bolus injection induced convulsions in 6 out of 10 mice(60% of convulsing mice) in group 1. Increasing the totaltime of IP infusion of bupropion ... increasing the IP infusiontime of this fixed dose was initially associated with anincrease in the percentage of convulsing mice at 15 mininfusion time followed generally by a decrease to 0% of convulsing ... progres-sively reduced odds of having convulsions, with the oddsmarkedly reduced by 55% with the infusion time of 30min, by 91% with infusion time of 90 min, and almostzero at 240 min. These...
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Báo cáo y học: "Assessment of immune response to repeat stimulation with BCG vaccine using in vitro PBMC model" pdf
... [13]. In India, a single dose of BCGvaccine is given within one week of the birth of child. Theincidence of TB in India is very high and repeated immu-nization is needed as it is done in other ... analyzedusing FlowJo software by gating on the lymphocyte popu-lation in forward scatter (FSC) and side scatter (SSC).The gate was set around the lymphocytes to excludeother cells from analysis. ... Galic SM: Enhancing the protective efficacy of Mycobacterium bovis BCG vaccination against tuberculosis by boosting with the Mycobacterium tuberculosis major secretory protein. Infect Immu 2005,...
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Báo cáo y học: " Protection of pulmonary epithelial cells from oxidative stress by hMYH adenine glycosylase" pptx
... chain reactions by accepting electrons,include α-tocopheral (vitamin E), ascorbic acid (vitaminC), niacin (vitamin B), riboflavin (vitamin B2), vitamin A,and ceruloplasmin [1,2,9]. These systems ... pulmonary disease (COPD),asthma, cystic fibrosis, ischemia-reperfusion injury, drug-induced lung toxicity, cancer and aging [1-4]. Althoughthe use of oxygen may be clinically indicated in hypox-emic ... many clinical situations.Such clinical settings include acute respiratory distresssyndrome (ARDS), infants of prematurity going on todevelop bronchopulmonary dysplasia (BPD), pathogene-sis of...
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Báo cáo Y học: A Ca2+/CaM-dependent kinase from pea is stress regulated and in vitro phosphorylates a protein that binds to AtCaM5 promoter ppt
... supported partly by internal grants from theInternational Center for Genetic Engineering and Biotechnology andfunds from Department of Science and Technology, Government of India. We thank Prof. S. ... regulated in response to multiplestresses and probably has a role at the very beginning of multiple stress signaling pathways [37]. Involvement of CDPKs in stress signaling has also been shown by using ... regulated by both protein phosphorylationand dephosphorylation in cultured tobacco cells. Plant J. 20,571–579.59. Miao, Y. J. & Wang, J .Y. J. (1996) Binding of A/T-rich DNA by three high mobility...
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Báo cáo y học: "Discovering and validating unknown phosphosites from p38 and HuR protein kinases in vitro by Phosphoproteomic and Bioinformatic tools" doc
... spectrometry (MS). P38 and HuR protein kinases have been reported extensively in the generalprinciples of signalling pathways modulated by phosphorylation, mainly by molecular bi ology and western ... phosphorylation of Ser48 in the first protein RNA recognition motif of HuR haspotentially a stabilizing effect, exerting a regulatory role onthe biological function of protein by regulating the mainte-nance ... proteins were expressed in Escherichiacoli. The kinase assay was carried out incubating with dif-ferent types of protein phosphat ase inhibitors in order toincrease the levels of protein-kinases...
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Báo cáo khoa học: Modulation of nitric oxide-mediated metal release from metallothionein by the redox state of glutathione in vitro doc
... metallothioneinand inducible nitric oxide synthase (iNOS) are induced by the same factors and the zinc released from metallothionein by NO suppresses both the induction and activity of iNOS. In a search for a ... are various indications of increased flexibility andmetal mobility in the b-domaininMT-1[8].Thenaturallybound metal zinc can be displaced by cadmium up to about5 mol per mol protein by simple ... earlier [31], zinc is more readily released from MTs than cadmium, which is probably a combination of tighter binding of cadmium than zinc in metallothioneinsand the preference of zinc in the more...
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