... stained with hematoxylin and eosin, and then examined and graded under the microscopefor histopathological changes in the joints [18], includinginflammatory cell infiltrate, synovial hyperplasia, ... from Harlan SpragueDawley (Indianapolis, IN, USA), and then maintained in the vivarium facility of the University of Maryland School of Medi-cine (UMB). All procedures performed on these animals ... of action of many of these products are poorly defined, or not at all. Thus, thereis a need to systematically study and define the mechanismsunderlying the activity of CAM products that have...