Báo cáo y học: "The QICKD study protocol: a cluster randomised trial to compare quality improvement interventions to lower " pot

... for citation purposes)Implementation ScienceOpen Access Study protocolThe QICKD study protocol: a cluster randomised trial to compare quality improvement interventions to lower systolic BP ... consent to participate.4. Agreement to participate in whichever arm of the study they are randomly allocated.5. Practice has had the same computer system for the lastfive years and has no plans to ... study activities.These will vary according to the arm of the study they areallocated to. The core study sample: a three-arm cluster randomised trial comparing Usual practice with Guidelines and...

Báo cáo y học: " The working alliance in a randomized controlled trial comparing online with face-to-face cognitive-behavioral therapy for depression" pptx

... therapist’s experience with internet-based therapies. Data analysis SPSS 17.0 for Windows was used for all analyses. In preliminary analyses, we compared the online and face -to- face group at ... 10 study coordinator and was not stratified by any participant characteristics. Seven (22%) participants in the online group and two (7%) participants in the face -to- face group failed to finish ... Patients and therapists were asked to evaluate the quality of the working alliance at post-treatment; patients additionally completed the Working Alliance Inventory at mid-treatment after 4...

Báo cáo y học: " The MATISSE study: a randomised trial of group art therapy for people with schizophrenia" pdf

... schizophrenia [19], we promoted total symptomscore as a co-primary outcome measure. Finally, earlydata demonstrating lower levels of attendance atgroups than we anticipated led us to increase the totalnumber ... weplanned to randomise 376 participants, 94 at eachcentre.Statistical analysisAll primary statist ical analys is will use the intention -to- treat principle. T he statistical pac kage STATA (version11.0) ... included. Study interventions The MATISSE trial has three treatment conditions:referral to group Art Therapy plus standard care, refer-ral to an activity group plus stand ard care, and standardcare...

Tài liệu Báo cáo Y học: The solution structure and activation of visual arrestin studied by small-angle X-ray scattering pot

... 80 kDa at 180 lM, to just under 100 kDa at1300 lM. A qualitative analysis of these data indicates that theapparent molecular mass at low protein concentrationsapproaches that of a monomer, ... theconformational changes in arrestin that lead to activationare unknown. Small-angle X-ray scattering (SAXS) wasused to investigate the solution structure of arrestin andcharacterize changes attendant ... bothcrystal structures [9,10] has a radius of gyration of almost4.3 nm, and would have a forward scattering approximatelytwice as large as that observed by us. Neither of theseparameters are...

Báo cáo Y học: The regulatory subunit of a cGMP-regulated protein kinase A of Trypanosoma brucei docx

... activity. Thisinteraction potentially allows a crosstalk between cAMPpathways and ras-mediated pathways in cell cycle control.In addition to its many roles as an intracellular messenger,cAMP also ... counterparts.Despite this overall similarity between mammalian andtrypanosomal regulatory subunits, the trypanosomal homo-log binds cGMP rather than cAMP, and the trypanosomalPKA is activated by ... phosphorylates a PKA-speciﬁc substrate.Protein kinase activity assays of immunoprecipitates. (Top) Coomassie-stained gels, molecular mass markers are IgG heavy chain (50 kDa) andthe PKA substrate...

Báo cáo y học: "The VH gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus" potx

... lymphopaenia, thrombocytopaenia,and homogeneous antinuclear antibodies characterized asanti-DNA antibodies. At the time of splenectomy the patienthad detectable antibodies against DNA (Crithidia ... was followed by incubationwith rabbit anti-mouse IgG (DAKO A/ S), and an alkalinephosphatase/anti-alkaline phosphatase complex (DAKO A/ S). Immune complexes containing alkaline phos-phatase/anti-alkaline ... min. The Taq polymerase used was of high-fidelity quality (Expand Easy; Roche, Mannheim, Germany),which has a very low error rate. Secondary amplificationused individual primers for each of the...

Báo cáo y học: "The retinoic acid binding protein CRABP2 is increased in murine models of degenerative joint disease" pot

... study, Crabp2 was found to be elevated in DJD in a rat model of OA [29,30]. We foundCrapb2 to be significantly increased in early OA, indicatingthat the retinoic acid pathway may play a role ... Lapadula G, Nico B, Cantatore FP, La Canna R, Roncali L, PipitoneV: Early ultrastructural changes of articular cartilage and syn-ovial membrane in experimental vitamin A- induced osteoar-thritis. ... regard to environmental factors, the biggest contributor is most likely to be physical activity/trauma and underlying medical conditionsthat place a greater mechanical burden on articular cartilage.The...

Báo cáo y học: "The P2X7 receptor is a candidate product of murine and human lupus susceptibility loci: a hypothesis and comparison of murine allelic products" potx

... belongs to a category that bears many of the hall-marks of 'classic' caspase-dependent apoptosis, but also to other categories such as cytoplasmic vacuolization moreoften associated ... weresequenced using an ABI PRISM Big Dye terminator readyreaction kit (Applied Biosystems, Warrington, UK) andwere analysed on a 3700 DNA Analyser (Applied Biosys-tems). Nucleotide and amino acid substitutions ... M:Circulating P- and L-selectin and T-lymphocyte activation andpatients with autoimmune rheumatic diseases. Clin Rheumatol1999, 18:28-32.15. Ren Y, Tang J, Mok MY, Chan AW, Wu A, Lau CS: Increasedapoptotic...

Báo cáo y học: " The RNA interference pathway: a new target for autoimmunity" pot

... Although they wereinitially reported to be specifically associated with systemiclupus erythematosus [7], a later study showed that auto-antibodies to the Su antigen are found in a variety of systemicrheumatic ... molecular modifications. Thediversity of autoantibody specificities and their associationwith particular diseases may be related to the combination ofgenetic and environmental factors that are ... RNAimachinery is that RNAi was initially recognized as an antiviralmechanism in plants and certain invertebrates [14]. Theevolutionary conservation of RNAi suggests a similar role forRNAi in mammals, which...

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