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Báo cáo y học: "Riding the knowledge translation roundabout: lessons learned from the Canadian Institutes of Health Research Summer Institute in knowledge translation" doc

Báo cáo y học:

Báo cáo y học: "Riding the knowledge translation roundabout: lessons learned from the Canadian Institutes of Health Research Summer Institute in knowledge translation" doc

... ScienceOpen AccessMeeting reportRiding the knowledge translation roundabout: lessons learned from the Canadian Institutes of Health Research Summer Institute in knowledge translation Michelle ... Corresponding author AbstractBackground: Funding the education and training of the next generation of health researchers is akey mandate of the Canadian Institutes of Health Research (CIHR) knowledge ... participatory action research (PAR),Table 2: Summary of curriculum from the 2008 Canadian Institutes of Health Research Summer Institute Activity Presenter TopicDay 1Welcome Jeremy GrimshawPlenary...
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báo cáo khoa học:

báo cáo khoa học: " Riding the knowledge translation roundabout: lessons learned from the Canadian Institutes of Health Research Summer Institute in knowledge translation" docx

... training of the next generation of health researchers is akey mandate of the Canadian Institutes of Health Research (CIHR) knowledge translation (KT)portfolio. The field of KT is growing daily; ... knowledge translation roundabout: lessons learned from the Canadian Institutes of Health Research Summer Institute in knowledge translation Michelle E Kho*1, Elizabeth A Estey2,3, Ryan T DeForge4, ... participatory action research (PAR),Table 2: Summary of curriculum from the 2008 Canadian Institutes of Health Research Summer Institute Activity Presenter TopicDay 1Welcome Jeremy GrimshawPlenary...
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Báo cáo y học: "Single food focus dietary guidance: lessons learned from an economic analysis of egg consumption" docx

... tosome extent. Only about one-fourth of low-density lipo-proteins in the body are associated with diet and the remainder is produced by the liver or other cells in the body [1]. The two major strategies ... the benefits associated with the otherconditions, the most likely scenario associated with eating an egg a day is savings of $2.82 billionannually with uncertainty ranging from a net cost of ... AMD in particular. The use of devices and the costs of these devices, for example,increased steadily as visual acuity decreased in patientswith AMD [18]. Similarly, the use of caregiving increasedas...
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Báo cáo y học: "Escape is a more common mechanism than avidity reduction for evasion of CD8+ T cell responses in primary human" pdf

... avidity for the index sequence epitope. Interestingly, we also fo undfour examples of increases in response avidity over the first year of infection. Two of these occurred in associa-tion with intra-epitopic ... than initially subdominant responses of lower avidity [32,33]. Further, we assessed changes in response avidity over only the first year of infecti on: the longer interval between the time-points ... occurs verycommonly during acute/early HIV-1 infection and (ii)tha t in a minimum of 82% of cases, the mutations evol-ving within the epitope resulted in impaired recognitionby the primary CD8+...
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Báo cáo y học: "Geographical information system and access to HIV testing, treatment and prevention of mother-to-child transmission in conflict affected Northern Uganda" pot

... registers.Ethical approval The study received an approval from the Uganda Ministry of Health and the offices of the district directors of health services in all the three districts. The methodology wasalso ... administrative point designated for meetings in the camp as identified by the camp commandant whereas in the case of health facility the coordinates were taken 10meters away from the main administrative ... of the stock-outs of HIV test kitsand drugs at lower health facilities reflect limited capacity of supply chain system probably as a result of insecurity orfunding. Similarly, shortage of health...
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Báo cáo Y học: Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors potx

Báo cáo Y học: Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors potx

... eIF2Bactivity under any of the stress conditions tested here (datanot shown), seemingly ruling out a role for this protein in the inhibitory effects of all three stresses on protein synthesis in these ... recycling of eIF2 to thisform [29,30]. The activity of eIF2B can be modulated in avariety of ways [29,31] including by its own phosphoryla-tion, and through phosphorylation of the a subunit of ... min) caused a profound inhibition of protein syn-thesis. In each case this was accompanied by dephosphory-lation of the eukaryotic initiation factor (eIF) 4E-bindingprotein 1 (4E-BP1) and increased...
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Báo cáo y học: "Grb2-associated binder 1 polymorphism was associated with the risk of Helicobactor pylori infection and gastric atrophy"

... that bind to the SH2 domains. The tandem SH2 domains bind to Tyr-627 and Tyr-659 simultaneously in a specific orientation, in which Tyr-627 binds to the N-SH2 domain and Tyr-659 binds to the ... previously that G/G of the PTPN11 gene encoding SHP-2 increased the risk of gastric atrophy among the seropositive subjects [18]. The present study examined the association of a polymorphism of ... diagnosis of cancer. In summary, the Gab1 A/A was associated with the low risk of H. pylori infection while the G/A and A/A genotypes together may increase the risk for gastric atrophy. The biological...
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Tài liệu Báo cáo Y học: Bivalent cations and amino-acid composition contribute to the thermostability of Bacillus licheniformis xylose isomerase doc

Tài liệu Báo cáo Y học: Bivalent cations and amino-acid composition contribute to the thermostability of Bacillus licheniformis xylose isomerase doc

... Asboth the Ea of inactivation and the temperature at which the enzyme starts inactivating at a measurable rate increase from the apoenzyme to the Mn2þ-containing enzyme, loss of the metal cofactor ... between the buffer and the enzyme by preincubating the enzyme–metal mixture at30 8C for 30 min. Remaining activity was measured withglucose as the substrate in the presence of 4 mM CoCl2. The apoenzyme ... on xylose, the apoenzyme activity was tested on both sugars in the presence of increasing concentrations of each cation (in the chloride form; Fig. 4). In the absence of metal, the apoenzyme...
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Báo cáo Y học: Extra terminal residues have a profound effect on the folding and solubility of a Plasmodium falciparum sexual stage-specific protein over-expressed in Escherichia coli pptx

Báo cáo Y học: Extra terminal residues have a profound effect on the folding and solubility of a Plasmodium falciparum sexual stage-specific protein over-expressed in Escherichia coli pptx

... only partially soluble in five of the constructsresulting in very poor yields. Intriguingly, in the sixth con-struct, the yield of soluble fusion protein with an extendedcarboxyl terminus of ... solubility of fusion proteins is not necessarily indicative of either properfolding or of increased solubility of the protein of interest.We propose that the success of fusion protein systemsshould ... protein quality between Pfg27Aand the rest of the constructs was retained. Therefore, the differing proteinsolubilities were inherent in the constructs and could not bemodulated by varying the...
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Báo cáo Y học: Substrate selectivity and sensitivity to inhibition by FK506 and cyclosporin A of calcineurin heterodimers composed of the a or b catalytic subunit potx

Báo cáo Y học: Substrate selectivity and sensitivity to inhibition by FK506 and cyclosporin A of calcineurin heterodimers composed of the a or b catalytic subunit potx

... between the CaM-binding domain and the CnB-binding helix and increases the affinity of the CaM-bindingdomain for Ca2+/CaM [25,26]. The regulation of the CaM-binding domain by CnB may partly account ... Ca2+-binding to the low affinity sites, the CaM-binding domaininteracts with the exposed side of the CnB-binding helix [26].Calcium binding to the low affinity sites on CnB disrupts the interaction ... shown in the crystal structure, the N-terminus of CnA interacts with the C-terminal half of CnB as part of a CnB-binding cleft,suggesting that the interaction of the CnA N-terminus withCnB is involved...
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