... nuclear receptors share a conserved structural andfunctional organization, including a highly conservedDNA-binding domain, a C-terminal ligand-bindingdomain, and two transcriptional activation ... Likewise,corepressor and coactivator complexes contain histonemodifying enzymes (e.g. acetylases, deacetylases, methyl-transferases, and kinases) that covalently modify specificlysine, arginine, or serine residues ... coactivator associated arginine methyltrans-ferase; CBP, CREB-binding protein; HAT, histone acetyltransferase;HDAC, histone deacetylase; HMT, histone methyltransferase; NCoR,nuclear receptor...