... models of severe sepsis and systemicinfection. Crit Care 2007, 11:R122.70. Abeyama K, Stern DM, Ito Y, Kawahara K, Yoshimoto Y, TanakaM, Uchimura T, Ida N, Yamazaki Y, Yamada S, Yamamoto Y, Yamamoto ... proinflammatory mediators called alarmins. As a group,alarmins display distinct intracellular and extracellularactivities, with potent stimulation of the innate immune system as their cardinal feature. ... established the alarmin activity of HMGB1 in acute and chronic inflammatory conditions, including the rheumatic diseases. Since HMGB1 may be a target of newtherapy, HMGB1 biology has emerged as...