báo cáo khoa học: "First-in-class, first-in-human phase I results of targeted agents: Highlights of the 2008 American Society of Clinical Oncology meeting" pot

Tài liệu Báo cáo khoa học: "STRING-TREE CORRESPONDENCE GRAMMAR: A DECLARATIVE GRAMMAR FORMALISM FOR DEFINING THE CORRESPONDENCE BETWEEN STRINGS OF TERMS AND TREE STRUCTURES" pdf

... tanciations of the variables in STRUCTU- RE can be obtained only by identifying (an operation intuitively similar to the standard notion of unification - again, see later in fig. 5) the STRUCTURE ... STCG. (Note that the rules with properties similar to the rule $2 entail a definition of direct derivation which is more complex than the classical definition). The set of rules in a grammar ... not implicit and dependent on the combi- nation of grammar rules applied (as in derivation trees). The inclusion of the substring-subtree correspondence is also another characteristic of the...

Báo cáo khoa học: A single EF-hand isolated from STIM1 forms dimer in the absence and presence of Ca2+ ppt

... motif and the SAM region have the potentialto facilitate oligomerization, it is challenging to differ-entiate which region contributes to the oligomerizationprocess.To overcome the limitations ... of investigating the Ca2+-binding sites in native Ca2+-binding proteins, weestablished a grafting approach to dissect their site-speciﬁc properties. This approach has been used in the investigation ... one-half of the population of the EF-hand motif in STIM1 is occupied by Ca2+.Removing the proposed Ca2+-coordinating residues inpositions 1 and 3 of the EF-hand motif signiﬁcantlycompromised the...

Báo cáo khoa học: Transcriptional activity and Sp 1⁄3 transcription factor binding to the P1 promoter sequences of the human AbH-J-J locus docx

... insulin-like growth factor-1 requires the induction of Sp1 protein [41]. In discussing the possi-ble implications of targeting Sp1 transcription factor(s)with transcription factor decoy oligonucleotides, ... previousstudies showing that the transcription of other TATA-less promoters frequently involves the action of proxi-mal Sp1 sites [24,25]. The mapping of the initiation of transcription using 5¢-RACE ... present the maximal transcriptional activity of each promoter [13].aP1 transcription initiation sites183 bpbMABFig. 3. P1 transcription initiation site mapping. (A) 5¢-RACE analysis of AbH-J-J...

báo cáo khoa học: "First-in-class, first-in-human phase I results of targeted agents: Highlights of the 2008 American Society of Clinical Oncology meeting" pot

... purposes)Journal of Hematology & Oncology Open AccessReviewFirst-in-class, first-in-human phase I results of targeted agents: Highlights of the 2008 American Society of Clinical Oncology meetingAndrea ... successful inhibition of designated targets, these phase I trial results suggest potential for using biomarkersto help predict and monitor clinical response.This discussion will focus on phase I results ... andrea.molckovsky@gmail.com; Lillian L Siu* - Lillian.Siu@uhn.on.ca* Corresponding author AbstractThis review summarizes phase I trial results of 11 drugs presented at the American Society of Clinical Oncology meeting...

Tài liệu Báo cáo khoa học: "From HOPE en I''''ESPERANCE On the Role of Computational Neurolinguistics in Cross-Language Studies " pptx

... pragmatic interpretation. Each piece of information is a thresholding device with memory. It has an activity value, initially at a resting state, that is modified over time depending on the input, ... meaning. It is the in interaction of the results of these asynchronous processes that the process of comprehension is defined. The processes are independent of the know- ledge representations ... strictly linguistic analysis. The remainder of the paper focuses on our initial work in the adaptation (Gigley, 1984). As the research is currently underway, the discussion will raise several...

Báo cáo khoa học: "Crossed Serial Dependencies:i low-power parseable extension to GPSG" ppt

... allows some vestige of compositionality to persist in the semantics, I think that at the very least a serious reconsideration of the BKPZ proposal is in order. IV. CONCLUSIONS It is of course ... Schemata in GPSG. In Proceedings of the Nineteenth Annual Meeting of the Association for Computational Linguistics. ACL, Stanford, CA. Also DAI Research Paper 165, Dept. of Artificial Intelligence, ... method of determining their end is required. Numerous possibilities exist, of which we have chosen a relatively inefficient but conceptually clear approach. We compose lists of triples, rather...

BÁO CÁO KHOA HỌC " ĐẶC ĐIỂM NGOẠI HÌNH, SINH TRƯỞNG, SINH SẢN CỈA GIỐNG GÀ NHẬP NỘI ZOLO VÀ BOR " pptx

... nghiên cứu khoa học giữa Viện Chăn nu i v i Tiểu dự án II, tháng 8 năm 2007 các giống gà hướng trứng Zolo và Bor cũng ñược tiếp nhận. Viện ñã giao cho Trung tâm Thực nghiệm và Bảo tồn vật nu i ... di truyền của hai giống gà này, ñồng th i kết quả chiều ño cũng chứng minh cả hai giống gà có ñặc i m là các giống hướng trứng. Tỷ lệ nu i sống Kết quả t i bảng 4 ñã cho thấy ở TH3, hai giống ... weeks of age was similar (53,0g). The fertility rate of eggs and hatchability of both Zolo and Bor chicken were 93.0 and 81 - 82%, respectively. Key word: Zolo chickens, Bor chickens ðẶT VẤN...

Tài liệu Báo cáo khoa học: a-Defensins increase lung ﬁbroblast proliferation and collagen synthesis via the b-catenin signaling pathway doc

... of a-defensins can also be found outsideneutrophils in the fibrotic foci in the lungs of IPFpatients [5,8]. In addition to potential antimicrobialeffects, a-defensins in the lung tissue may ... fibroblasts.Inhibition of the b-catenin signaling pathwayusing quercetin blocked the a-defensin-inducedincrease in lung fibroblast proliferation andcollagen synthesisTo investigate the role of b-catenin ... fibroblast proliferation and collagen synthesisinvolve the b-catenin signaling pathway.Inhibition of b-catenin signaling pathway usingquercetin blocked the a-defensin-inducedincrease in collagen...

Tài liệu Báo cáo khoa học: A novel coupled enzyme assay reveals an enzyme responsible for the deamination of a chemically unstable intermediate in the metabolic pathway of 4-amino-3-hydroxybenzoic acid inBordetellasp. strain 10d doc

... cofactor of the deaminase from strain 10dbecause the enzyme could not be puriﬁed in large enou ghquantities. We previously reported the identiﬁcation of the enzyme involved in the initial step of the ... responsible for the deamination of a chemically unstable intermediate in the metabolicpathway of 4-amino-3-hydroxybenzoic acid inBordetellasp. strain 10dChika Orii1, Shinji Takenaka2, Shuichiro ... 2,5-pyridinedicarboxylic acid in the reac-tion mixture. To reveal the subsequent metabolism in vivo,including the deamination step the concentrated crudeextracts of strain 10d grown on 4-amino-3-hydroxybenzoicacid...

Báo cáo khoa học: Caenorhabditis elegans metallothionein isoform speciﬁcity – metal binding abilities and the role of histidine in CeMT1 and CeMT2 potx

... acidiﬁed at pH 2.4. It isworth noting that at the end of the titration, even afteraddition of excess Cu (I) , some species still retainedZn(II) ions. The discussion of the Cu (I) coordination ... synthesized in the presence of supplementedZn(II) or Cd(II). In CeMT2, the unique C-terminal histidine abolishes the Cu-thionein character that this isoform would otherwise exhibit.AbbreviationsDEPC, ... absorptions,which would have been highly informative regarding the presence of Zn-His bonds.In vivo and in vitro Cd(II)-binding abilities of CeMT1 and CeMT2Unlike the results obtained for Zn(II)...

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