báo cáo khoa học: "Novel therapies in breast cancer: what is new from ASCO 2008" ppsx
báo cáo khoa học: "Novel therapies in breast cancer: what is new from ASCO 2008" ppsx
... awaiting data analysis.[11] It is alsocurrently being evaluated in phase I/II studies in combina-tion with paclitaxel as well as in combination with vinor-elbine in patients with advanced breast ... anti-tumor activity for MBC in the first-line setting. Furtherstudies using axitinib in breast cancer are ongoing.Topoisomerase II inhibitorsC1311C1311 is an inhibitor of topoisomerase II whose designwas ... asymptomatic decline in LVEFoccurring in 5% of the patients in the combination armand in 2% of the patients in the lapatinib monotherapyarm. This was the largest study using the combination ofthese...
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báo cáo khoa học: "Novel therapies in genitourinary cancer: an update" doc
... results were disappointing in that the ORRand OS appear inferior to standard cisplatin-based regi-mens.VinflunineVinflunine is a novel vinca alkaloid that inhibits tubulinand acts to inhibit assembly ... most exciting findings in the field of prostatecancer is the recognition that persistent androgen signal-ing remains critical in CRPC. Approaches to targetingandrogen signaling including androgen ... better in the sunitinibgroup. This trial ultimately established sunitinib as thefirst-line therapy for advanced RCC.Sunitinib is also being analyzed in the adjuvant setting.The 'Sunitinib...
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Báo cáo khoa học: Novel isoenzyme of 2-oxoglutarate dehydrogenase is identified in brain, but not in heart potx
... OGDH isoform and itsimplication in brain metabolismDistinguishing proteins with highly similar primarystructures, such as the products of alternative splic-ing or of different genes (isoforms ... struc-ture–function analysis of protein–protein interactions in OGDHC and provide important insights into phys-iologically relevant issues. A more pronounced disso-ciation of the E3 component from brain versus ... apart from housekeeping OGDH, OGDHL is synthesized in brain. Integration of the OGDHL isoenzyme into thecomplex, which was predicted by our structure–function analysis [16], is evident from...
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Báo cáo khoa học: Novel b-1,3-, 1,6-oligoglucan elicitor from Alternaria alternata 102 for defense responses in tobacco docx
... other fungi, including A. alternata IFO6587, could not induce, or weakly induce chitinase activity. The purifiedelicitor was soluble in 75% methanol and showed the chitinase-inducingactivity ... As an index of eli-citor activity, we measured the induction of TBC-1, atobacco class IV chitinase homolog [14]. Interestingly,the activity of this isozyme increased remarkablyfollowing treatment ... signaling pathwaysinduced by AaGlucan seems to be somewhat different from the pathways induced by protein elicitors. SAand MeJA are well-known plant hormones involved in plant defense signaling....
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Báo cáo khoa học: "Predictive factors for breast cancer in patients diagnosed atypical ductal hyperplasia at core needle biopsy" doc
... purposes)derline lesion on histology that is difficult to distinguish from low grade DCIS on the small tissue sample providedby CNB. Because of this difficulty, clinico-pathologic andradiologic findings ... Signifi-cant discordance has been reported isn CNB diagnosis ofADH, with 7%-87% of cases proving to be DCIS or inva-sive carcinoma on subsequent surgical excision [8-14].This problem arises from the ... determined to be an independ-ent predictive factor for breast cancer at surgical excision in patients with diagnosed ADH at CNB. Consistent withour findings, Ko et al [18] observed an increase in...
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Báo cáo khoa học: "Postmastectomy irradiation in breast in breast cancer patients with T1-2 and 1-3 positive axillary lymph nodes: Is there a role for radiation therapy" ppsx
... survival in breast cancer? A meta-analysis. J Clin Oncol 2000,18:1220-1229.24. Sotiriou C, Wirapati P, Loi S, et al: Gene expression profiling in breast cancer: understanding the molecular basis ... At this time, the role ofPMRT for women with 1 to 3 positive lymph nodesremains uncertain and is being examined in a rando-mized clinical trial”. Many surgeons and radiation oncol-ogist are ... expressed in the following cita-tion from the NIH Consensus Report 2000 [5]: “There is evidence that women with high risk of LRR afterMRM benefit from PMRT. This high-risk groupincludes women...
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báo cáo khoa học: " Platinum resistance in breast and ovarian cancer cell lines Niels Eckstein" pptx
... resistant phenotype is a major hurdle in curative cancer therapy approaches and many scientists around theworld are focussing on this issue. This review covers new findings in this field during ... but also promising new idea is the use of PARP1 inhibitors as chemosensitisers in com-bination with Platinum-based chemotherapy. Preliminaryresults from clinical trials are promising and justifyresearchers ... This is supported by the finding that the Cis-platin-resistance models in our studies showed cross-resis-tance towards Doxorubicine, an anti-cancer drug, which is chemically unrelated to Cisplatin....
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Báo cáo khoa học: "Reirradiation of recurrent breast cancer with and without concurrent chemotherapy" ppt
... injury: radiation-induced fibrosis and necrosis. SeminRadiat Oncol 2007, 17:99-107.7. Bedwinek JM, Fineberg B, Lee J, Ocwieza M: Analysis of failures fol-lowing local treatment of isolated local-regional ... course of radiation to thewhole breast is used with caution as increased toxicity ofskin and subcutaneous tissue is feared. Nevertheless, in recent years several investigators reported on reirradiationeither ... number; IMC: internal mammary chain; LN: lymph nodes.Clinical characteristics of recurrent breast carcinoma patients treated with reirradiation. The initial and recurrence TNM staging and site...
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Báo cáo khoa học: " Clinical outcome of breast cancer occurring after treatment for Hodgkin''''s lymphoma: case-control analysis" pdf
... DCIS 2.85 Invasive Invasive 9.66 Invasive Invasive 42.67 Invasive Invasive 55.18 Invasive Invasive 77.79 DCIS Invasive 83.210* Unknown DCIS 130.611 Invasive DCIS 197.1Abbreviations: DCIS, ... contralateral breast cancers and time interval in- between in patients with bilateral diseasePatient No First Second Interval (months)1 DCIS Invasive 0.02 Invasive DCIS 0.03 DCIS Invasive 1.44 Invasive ... unknown. Breast Cancer: Pathology & StageOf the 28 index breast cancers, 21 (75%) were infiltratingduct carcinoma (one with mucinous features), one(3.6%) was infiltrating lobular carcinoma,...
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Báo cáo khoa học: " Oral Pirfenidone in patients with chronic fibrosis resulting from radiotherapy: a pilot study" ppsx
... looking at theeffectiveness of Pirfenidone in ameliorating or treatingestablished fibrosis resulting from radiation therapy. Weinitiated this pilot study to examine whether Pirfenidone,administered ... well as human in vitro studies to alter cytokinesignaling and reduce or eliminate pulmonary inflamma-tion and fibrosis. Pirfenidone is currently being evaluated in phase 2 and 3 clinical trials ... spontaneously improve. This is especially truefor those with well established fibrosis and persistentfunctional loss. For all patients in this study, ROMimproved and in several this was associated...
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