báo cáo khoa học: "Phenylhexyl isothiocyanate has dual function as histone deacetylase inhibitor and hypomethylating agent and can inhibit myeloma cell growth by targeting critical pathways" doc
báo cáo khoa học: "Phenylhexyl isothiocyanate has dual function as histone deacetylase inhibitor and hypomethylating agent and can inhibit myeloma cell growth by targeting critical pathways" doc
... AccessResearchPhenylhexyl isothiocyanate has dual function as histone deacetylase inhibitor and hypomethylating agent and can inhibit myeloma cell growth by targeting critical pathwaysQuanyi ... suppresses growth and causes cell cycle arrest of RPMI8226 myeloma cellsFigure 1PHI suppresses growth and causes cell cycle arrest of RPMI8226 myeloma cells. (A). PHI suppresses growth of RPMI8226 myeloma ... shown that PHI can inhibit the his-tone deacetylase and induces histone hyperacetylation inHL-60 leukemia cells and prostate cancer cells [29-31].The status of histone acetylation was examined...
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Tài liệu Báo cáo khoa học: Myristoylation of the dual-specificity phosphatase c-JUN N-terminal kinase (JNK) stimulatory phosphatase 1 is necessary for its activation of JNK signaling and apoptosis pdf
... caspase-9 and poly(ADP-ribose) polymerase (PARP) (Fig. 5C). Wedetected both cleaved caspase-9 and PARP in JSP1-wtexpressing, floating cells. In contrast, cells expressingthe -G2A mutant, and ... carboxamidomethylated and maleylated lyso-zyme as substrate, and phosphatase activity was measured. Theresults (shown as activity relative to wild-type phosphatase) are themean of two experiments (±standard ... dual- specificity phosphatase; ERK, extracellular signal-regulated kinase; JKAP, c-JUN N-terminal kinase pathway-associatedphosphatase; JNK, c-JUN N-terminal kinase; JSP, c-JUN N-terminal kinase...
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Báo cáo khoa học: Caenorhabditis elegans has two genes encoding functional D-aspartate oxidases pot
... against theenantiomers l-Asp, l-Glu, and N-methyl-l-Asp and allneutral and basic d-amino acids examined. Thus, theproteins encoded by the cloned C47Ap and F18EpcDNAs can catalyze the deamination ... Extraction Reagent (Novagen), 50 lmFAD, and protease inhibitors (Roche Applied Science,Mannheim, Germany) (5 mL lysis buffer per g wet cell paste was used). The cell suspension was incubated ... functional DAAO activity, as it can deami-nate neutral and basic d-amino acids, whereas the recombinants C47Ap and F18Ep have functional DASPO activities, as they can deaminate acidicd-amino...
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Báo cáo khoa hoc:" Environmental enrichment has no effect on the development of dopaminergic and GABAergic fibers during methylphenidate treatment of early traumatized gerbils" ppsx
... theother hand, a former study has already revealed an effectof handling on the dopaminergic system without anymedication [13]. Interestingly, this handling effect wasonly significant in saline ... etiology and outcome ofpsychiatric diseases such as Attention-Deficit/Hyperactivity Disorder (ADHD). A former studyfrom our laboratory has shown that both methylphenidate (MP) and handling have ... transporter and thenoradrenalin transporter [3-5], and thus leads to anincreased extracellular concentration of DA [6,7]. Theneurobiological basis of ADHD is basically thought to becharacterized by...
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báo cáo khoa học: " What work has to be done to implement collaborative care for depression? Process evaluation of a trial utilizing the Normalization Process Model" potx
... Framework pub-lished in 2007 [10] emph asized the iterative nature ofthe tasks of defining and understanding the problem and its context, developing and optimizing and thenevaluating the intervention, ... challenging, and undoubtedlyeasier if the first contact was face-to-face:’They wanted counselling, even though I didemphasize that I wasn’t counselling, it took time, tobuilduptrustwiththem.’ (case ... randomisation of practices Individual randomisation of patients Group 1 Individual and professional/practice component Intervention Individual component Control No individual...
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Báo cáo khoa học: "Herpes simplex virus type 2 tegument protein UL56 relocalizes ubiquitin ligase Nedd4 and has a role in transport and/or release of virions" ppt
... interaction between Nedd4 and UL56 will help to clarify both cellular process and viral pathogenesis.MethodsCells and virusesVero cells (African green monkey kidney cells) wereobtained from ... PFU/ cell) , and infected cells and growth medium were har-vested together when almost all cells showed cytopathiceffects. After a cycle of freezing and thawing, supernatantswere cleared of cell ... debris by centrifugation at 3000 rpmfor 5 min at 4°C and stored at -80°C as virus stocks. Titersof virus stocks were determined on Vero cells by plaqueassay.Expression vectorsThe Nedd4 ORF was...
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Báo cáo khoa học: "Procalcitonin testing has the potential to reduce unnecessary antibiotic use in patients with suspected lower respiratory tract infections" ppsx
... an important public health problem and indiscriminate use of antibiotics has been implicated as a predisposing factor, it would be useful to have a rapid and ... admitted with suspected lower respiratory tract infection as the main diagnosis. Intervention: Patients were randomly assigned to either standard care (n=199) or PCT-guided treatment (n=124). In ... antibiotics was: strongly discouraged (PCT <0.1 µg/L), discouraged (≥0.1 and <0.25 µg/L), advised (≥0.25 and <0.5 µg/L), or strongly advised (≥0.5 µg/L). Re-evaluation was possible...
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Tài liệu Báo cáo khoa học: A DExD⁄ H box RNA helicase is important for K+ deprivation responses and tolerance in Arabidopsis thaliana docx
... Kronzucker HJ & Shi WM (2010) Root growth inhibition by NH4+in Arabidopsis is mediated by the root tip and is linked to NH4+efflux and GMPase activity. Plant Cell Environ 33, 1529–1542.52 Sun ... surface-sterilized and sownon Murashige and Skoog plates. Seeds were stratified at4 °C for 2 days, and then transferred to 22 °C for 2 weeks.Col-0 was used as the wild type, and was the genetic ... stress during plant growth and devel-opment. For plant DExH box helicase, however,Arabidopsis CAF ⁄ DICER-LIKE 1 has been shown tobe critical for the biogenesis of microRNAs and plantdevelopment...
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Tài liệu Báo cáo khoa học: Modulation of a-synuclein aggregation by dopamine in the presence of MPTP and its metabolite pptx
... itsfluorescence was first demonstrated to increase uponbinding to amyloid fibrils [20]. It has been used todetect cross b-sheet fibril formation by a-synuclein[19,21,22] as well as b amyloid [23] and huntingtin ... containingMPTP (A and C) and MPP+(B and D) were analysed by SDS ⁄ PAGE(A and B) on 5–15% crosslinked polyacrylamide gel and westernblotting (C and D). (A, B) Lane M, prestained molecular mass mark-ers; ... for recording the scan-ning electron micrographs and Shivcharan Prasad and Pinakin Makwana for technical assistance.References1 Pastor MT, Ku¨mmerer N, Schubert V, Esteras-ChopoA, Dotti...
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Tài liệu Báo cáo khoa học: Exposure of IgG to an acidic environment results in molecular modifications and in enhanced protective activity in sepsis doc
... aninherent property of each individual immunoglobulinmolecule. However, it has been previously shown by us, as well as by others, that the in vitro exposure ofmonoclonal and of polyclonal IgG to various ... preparations are used in patients with primary and secondary immunodeficiencies, as well as in anincreasing number of autoimmune and inflammatorydiseases. To the best of our knowledge, no compara-tive ... tryptophans, was used for the fluorescencespectra measurements. The fluorescence emission spectrawere recorded between 300 and 450 nm. The excitation and emission slits were both 10 nm, and the scan speed...
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