Báo cáo y học: "Radiographic correlates of hallux valgus severity in older people" pot
Báo cáo y học: "Radiographic correlates of hallux valgus severity in older people" pot
... or without hallux valgus, this study investi-gated hallux valgus across a broad spectrum of severity. MethodsThis study involved performing a variety of common hallux valgus x-ray measurements ... development of hallux valgus; rather, they are likely to develop in response to increasing hallux valgus deformity. However,as the inclusion criteria for this study involved partici-pants over 65 years ... correlatingthese to the cli nical severity of hallux valgus using theManchester Scale. The study utilised x-rays obtainedfrom 201 people who were taking part in a larger study of the effect of...
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Báo cáo y học: "Possible roles of Epstein-Barr virus in Castleman disease" potx
... localization by hematoxylin-eosinstain, immunohistochemistry, polymerase chain reaction and In- situ hybridizationResults: Hyaline-vascular type was diagnosed in 18 cases, plasma cell type in 1 and ... mainly in inter-follicular areas. There are12 cases having EBER signal in areas of germinal centersand 6 cases having signals in inter-follicular areas. In thegroup of EBV localized within ... rare and usually benign lym-phproliferative disease. It has many synonyms, includinggiant lymph node hyperplasia, angiofollicular hyperpla-sia, lymph node harmatoma, benign giant lymphoma,and...
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Báo cáo y học: "Increased production of soluble CTLA-4 in patients with spondylarthropathies correlates with disease activity" pps
... 3Representative analysis of intracellular Cytotoxic T Lymphocyte Antigen- 4 (CTLA-4) expression in peripheral blood lymphocyte subsetsRepresentative analysis of intracellular Cytotoxic T Lymphocyte Antigen- ... between soluble Cytotoxic T Lymphocyte Antigen- 4 (sCTLA-4) and clinical index of disease activity Bath Ankylosing Spond-ylitis Disease Activity Index in 165 patients with spondylarthropathies. ... P, Jenkinsson T, Kennedy LG, Whitelock H, Gaisford P,Calin A: A new approach to defining disease status in ankylos-ing spondylitis: the Bath Ankylosing Spondylitis Disease Activ-ity Index....
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Báo cáo y học: " Low concentration of ethanol induce apoptosis in HepG2 cells: role of various signal transduction pathways"
... its initial effect on protein kinases phosphorylation. The most strikingly and novel finding obtained hereby was the strong inhibition of the GPCR signaling pathway induced mainly by increased ... signaling pathways. The pro-apoptotic effect induced by ethanol was demonstrated by a strong inhibition of GPCR signaling pathway in association with a slight inhibition of JNK and NFκB signaling ... microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-54. 24. Pelech S, Sutter C, Zhang H. Kinetworks protein kinase multiblot analysis. Methods...
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Báo cáo Y học: The presence of a helix breaker in the hydrophobic core of signal sequences of secretory proteins prevents recognition by the signal-recognition particle in Escherichia coli doc
... variable in the interactionwith SRP [14,41,42]. However, the hydrophobicity of cysteine is even slightly lower than that of glycine [37].Therefore, the cross-linking of (G-10C)prePhoE to P48indicates ... preprotein istranslocated by an insertion–deinsertion cycle of SecA intothe SecYEG translocon [8]. Energy for the translocationprocess is provided by ATP hydrolysis by SecA [8,9] and bythe ... via the SRPinstead of the SecB pathway could be explained by theincreased hydrophobicity of the hydrophobic core of themutant signal sequence, because hydrophobicity was previ-ously reported...
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Báo cáo Y học: Coordinated action of protein tyrosine phosphatases in insulin signal transduction potx
... homogeneouspreparations of PTP-1B protein into Xenopus oo cytesdecreases t yrosine phosphorylation of proteins correspond-ing to the molecular m ass of the IR. Correspondingly,insulin-induced S6 kinase activity ... regulatory s ubunit of phosphatidylinositol 3-kinase(PI3-kinase). Binding to p85 recruits the p110 catalyticsubunit of PI3-kinase, resulting in the activation of the PI3-kinase pathway, a necessary ... method,mutagenesis of the conserved cysteine to serine (CfiS) or anaspartate to alanine (DfiA) within the catalytic domain of Fig. 1. Scheme of the major insulin signalingpathways. The activated insulin receptorphosphorylates...
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Báo cáo Y học: Differential regulation of telomerase activity by six telomerase subunits potx
... Alternatively, hTR and hTERTmay play a minimal catalytic activity in telomerase, whilethe assembly of other telomerase subunits may amplify theenzyme function. In this scenario, deletion of mTEP1 in embryonic ... of dyskerin, althoughshowing comparable inhibition of telomerase function in cells, exhibited a weaker inhibition of telomerase activity in the in vitro assay. As dyskerin is believed to be involved in ... morphology afterinduction of differentiation of HL-60 cells bydimethylsulfoxide and TPA. (A) HL-60 cellscultured in RPMI for 3 days (control for B),followed by cytospin analysis and staining(·1000)....
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Báo cáo Y học: Identification of mammalian-type transglutaminase in Physarum polycephalum Evidence from the cDNA sequence and involvement of GTP in the regulation of transamidating activity potx
... might be similar to that bywhich they inhibit the enzymatic activity of TGase 4.Hydrolysing activity of GTP was also found in thepurified PpTGase protein as in the case of TGase 2.Mammalian TGase ... calcium-binding protein in P. polycephalum, was shown to be a substrate of PpTGaseFig. 7. Time-courses of GTP hydrolysis by TGase 2, TGase 3, andPpTGase. GTP-hydrolysing activities of guinea pig ... by adding 20 lLofTGasessolution to the premixed solution and then incubating at37 °C for 1 h. TGase-catalysed conjugation of 5-(biotinam-ido)pentylamine into dimethylcasein was measured bystreptavidin-peroxidase,...
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Báo cáo Y học: The evolution of monomeric and oligomeric bc-type crystallins potx
... 2002introns in the evolutionary pathway to c-type genes, butrather the acquisition of an interdomain intron in theevolution of c-crystallins, and of both interdomain andintermotif introns in the ... in favour of a late insertion of introns in crystallin-type genes, as opposed to a late deletion of pre-existing introns, may be based on the intron-latetheory, originally proposed to explain ... side-chainsinvolved in these contacts are remnants of the ancestral,solvent exposed surfaces of single-domain crystallins, nowburied at interdomain interfaces of present day crystallins.As they...
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Báo cáo Y học: Detailed characterization of polydnavirus immunoevasive proteins in an endoparasitoid wasp doc
... (IEP-1) deter-mined in the prior study [21] is underlined. Theamino acid sequence (10 amino acids) of IEP-2determined in the present study is alsounderlined. Potential Asn-glycosylation sitesare ... respectively, instead of the calyxcells. Further, the expression of IEP proteins is notsynchronized with that of CkPDV capsid proteins; IEPproteins were observed approximately one day after theinitiation ... amino-acid sequence homology of theseproteins except within the EGF-like motif. Other PDV genefamily containing the cysteine motifs structurally analogousto the motif of conotoxins have also been...
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