... of p rostaglandinE2, prostaglandin F2a and prostacyclin by the endometrium and myometrium during menstruation are increased in tissuesobtained f rom m enorrhagic w omen [7,8]; and i ncreasedconcentrations ... cascade of molecular and cellular events withinthe endometrium, initiating its breakdown and culminating in Correspondence: Flora Peyvandi, MD, PhD, Angelo Bianchi BonomiHaemophilia and Thrombosis ... fibroids, pregnancy and childbirth. Pregnancy and childbirth, two important stages in the life of a woman, pose a special clinical ch allenge i n w omenwith inherited bleeding disorders, since information...