... multiplephysicians, including allergists and dermatologists, and had been treated with a variety of medications includingcertirizine, desloratadine, hydroxyzine, montelukast, ran-itidine, and diphenhydramine ... intradermal test revealed a 7 mm wheal with ery-thema. The histamine control showed a 9 mm wheal with erythema, and saline control was negative for wheal and erythema. Two healthy controls also ... the diagnosis may remain elusive for years. Wepresent a case of APD, and review the current literature in regards to clinical features, pathogenesis, diagnosis, and treatment options. Case A...