báo cáo khoa học: " Statin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma" potx
báo cáo khoa học: " Statin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma" potx
... fluvasta-tin and simvastatin decrease the activation of ERK1/2 Akt [4]. These findings are in agreement with the results of the present study and indicate that statins induce apoptosis via suppression ... whether the inhibi-tion of ERK1/2 and Akt activation in C6 glioma cellswas due to the inhibitory action of statins on FPP orGGPP biosynthesis via their mechanism of action. Sta-tins inhibited the ... that the mechanism of action is inhi-bition of GGPP biosynthesis [10,11]. These findings sug-gest that statins induce apoptosis by activation of caspase-3 through suppression of GGPP biosynthesis. GGPP...
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báo cáo khoa học: "Compound Kushen Injection suppresses human breast cancer stem-like cells by down-regulating the canonical Wnt/b-catenin pathway" potx
... AnimalInstitute of Peking Union Medical College and maintainedunder standard conditions according to the guidelines of the Institutional Animal Care and Use Committee of Peking University. The ... cellgrowth by inducing apoptosis [21] and inhibits the migra-tion, invasion a nd adhesion capacity by down-regulating the expression of CD44v6protein [22]. However, the underlying anti-cancer ... at both the protein and mRNA level. The maingenes and proteins in DDP group were comparable tothose in the control group, suggesting that Wnt/b-cateninPathway was still active in the DDP group...
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Báo cáo khoa học: Ca2+/calmodulin-dependent kinase II signalling cascade mediates P2X7 receptor-dependent inhibition of neuritogenesis in neuroblastoma cells docx
... (min)pAkt /Akt (R.U.) AKT pAKT03060Time (min)BBG 100 nMABCDEFFig. 8. P2X7 receptor inhibition increases Akt and GSK3 phosphorylation in N2a cells.(A, B) Western blots of pS473 Akt and ... resulting in Akt activation and GSK3 inhibition. It should be noted that increased Akt activ-ity can also induce the inhibition of GSK3, which hasbeen proposed to promote axonal growth and branch-ing ... identified and characterized, including other kinases involved in neu-ritogenesis, such as Akt [64] and GSK3 [65,66]. In order to estimate PI3K function, we studied whether the activity of Akt and...
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Báo cáo khoa học: Heme oxygenase-1 ⁄p21WAF1 mediates peroxisome proliferator-activated receptor-c signaling inhibition of proliferation of rat pulmonary artery smooth muscle cells pot
... group of CDK inhibitors comprising two families of proteins:inhibitor of kinase 4 ⁄ alternative reading frame and CDK inhibitor protein ⁄ kinase inhibitor protein. The inhibitor of kinase 4 ⁄ alternative ... kinase inhibitor protein family includesp21WAF1, p27Kip1, and p57Kip2. They halt the cell cycle in the G1phase by binding to, and inactivating,cyclin–CDK complexes [29,30]. The results of ... nontargetingcontrol siRNA transfection did not change the p21WAF1level in cells. Next, we investigated the in u-ence of the loss of p21WAF1on the effect of PPARc activation on suppression of...
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Báo cáo khoa học: Modular kinetic analysis reveals differences in Cd2+ and Cu2+ ion-induced impairment of oxidative phosphorylation in liver pot
... Cd2+on the kinetics of the CoQ-oxidizing module (A) and CoQ-reducing module (B). Effect of Cu2+on the kinetics of the CoQ-oxidizing module (C) and CoQ-reducing module (D). The kinetics of the CoQ-oxidizing ... CoQ-oxidizing module were obtained by titrating with a specific inhibitor of the CoQ-reducing module, malonate(0–3.125 lM). The kinetics of the CoQ-reducing module were obtained by titratingwith ... O·min–1·mg protein–1) JR (nmol O·min–1·mg protein–1)Fig. 4. Effect of Cd2+ and Cu2+ions on the kinetics of the CoQ-reducing and CoQ-oxidizing modules. Effect of Cd2+on the kinetics...
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báo cáo khoa học: " All-trans retinoic acid inhibits KIT activity and induces apoptosis in gastrointestinal stromal tumor GIST-T1 cell line by affecting on the expression of survivin and Bax protein" pdf
... All-trans retinoic acid inhibits KIT activity and induces apoptosis in gastrointestinal stromal tumor GIST-T1 cellline by affecting on the expression of survivin and Bax protein. Journal of Experimental ... and imatinib The result of isobologram was showed in Figure 5B. Alldata points in the combination fell within the envelope of additivity, the area surrounded by the three lines, sug-gesting that ... AccessAll-trans retinoic acid inhibits KIT activity and induces apoptosis in gastrointestinal stromaltumor GIST-T1 cell line by affecting on the expression of survivin and Bax proteinHoang Thanh...
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Tài liệu Báo cáo khoa học: An ecdysteroid-inducible insulin-like growth factor-like peptide regulates adult development of the silkmoth Bombyx mori docx
... of the input and the eluate of the chromatographywere resolved by Tricine ⁄ SDS ⁄ PAGE and then analyzed by Coo-massie Brilliant Blue staining (left) and western blotting (right).Lane 1: input ... suggesting that this peptide may alsoaffect the development of the wing disks at the prepu-pal stages. It is interesting to note that bombyxin-IIalso stimulated the growth of the wing disks in the butterfly ... vertebrateinsulins [7,8]. Bombyxin-II, one of the purified bomb-yxins, is a heterodimeric molecule in which two peptidechains are held together by disulfide bonds in exactly the same manner as in insulin...
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Tài liệu Báo cáo khoa học: A tyrosinase with an abnormally high tyrosine hydroxylase/dopa oxidase ratio Role of the seventh histidine and accessibility to the active site docx
... that the most characteristic signatures in the sequences are present in both proteins, tyrosinases and catechol oxidases; these include the six histidine resi-dues involved in the binding of a ... browning of fruits and vegetables, and morphogenesis and fruiting body formation in fungi.All of these processes involve melanin formation. In the bacterial kingdom there are some examples of ... the CuA and CuB binding sites to ligand the copperTable 3. Kinetic parameters for the two PPOs. The enzymes wereobtained from extracts of R. solanacearum strains mutated in the gene encoding the...
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Tài liệu Báo cáo khoa học: "Mining metalinguistic activity in corpora to create lexical resources using Information Extraction techniques: the MOP system" doc
... especially with the series of Mes-sage Understanding Conferences of the nineties, has focused on tasks such as creating and updating databases of corporate join ventures or terrorist and guerrilla ... on the pro-blem of identifying and organizing into a useful database structure the different linguistic consti-tuents of the candidate predications, a phase simi-lar to what are known in the ... enterprise in general. Whenever scientists and scholars advance the state of the art of a discipline, the language they use has to evolve and change, and this build-up is carried out under metalinguistic...
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Tài liệu Báo cáo khoa học: Phenol hydroxylase from Acinetobacter radioresistens S13 Isolation and characterization of the regulatory component docx
... monitored by the reduction of cytochrome c in the presence of NADH at 550 nm [1].Protein determinationProtein content was determined by the Bradford test [20],using bovine serum albumin as standard.PHI ... explain the regulatory effect. In fact, on addition of PHI, the fluorescence of PHR-bound flavin increases. Thisfinding points to a PHI-induced conformational change of PHR, possibly resulting in ... show iron- or sulfur-containing redox-centres in the pure protein. In agreementwith these findings, the emission spectrum of PHI,determined by spectrofluorimetry in the same conditions,exhibited...
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Từ khóa: Nghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngNghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt namNghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitPhát hiện xâm nhập dựa trên thuật toán k meansNghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùngNghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngNghiên cứu khả năng đo năng lượng điện bằng hệ thu thập dữ liệu 16 kênh DEWE 5000Định tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)Chuong 2 nhận dạng rui roNguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtChiến lược marketing tại ngân hàng Agribank chi nhánh Sài Gòn từ 2013-2015HIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀMMÔN TRUYỀN THÔNG MARKETING TÍCH HỢPTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲ