Báo cáo y học: " Induction of apoptosis and inhibition of cell growth by tbx5 knockdown contribute to dysmorphogenesis in Zebrafish embryos" pptx
Báo cáo y học: " Induction of apoptosis and inhibition of cell growth by tbx5 knockdown contribute to dysmorphogenesis in Zebrafish embryos" pptx
... Lu et al.: Induction of apoptosis and inhibition of cell growth by tbx5 knockdown contribute to dysmorphogenesis in Zebrafish embryos. Journal of Biomedical Science 2011 18:73.Submit your next ... 18:73http://www.jbiomedsci.com/content/18/1/73Page 4 of 10RESEARC H Open Access Induction of apoptosis and inhibition of cell growth by tbx5 knockdown contribute to dysmorphogenesis in Zebrafish embryosJenher Lu1,2*†, ... in vitro[30]. Our results revealed tbx5 insufficiency ultimatelyresulted in activation of apoptosis and inhibition of cell growth in whole individual of zebrafish embryo, though knockdown of...
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Tài liệu Báo cáo Y học: The solution structure and activation of visual arrestin studied by small-angle X-ray scattering pot
... phosphorylation of the C-terminus of R* and binding by arrestin. Phosphorylation somewhatdecreases the ability of R* to signal transducin. Rapid shut-off of R* signalling is then accomplished by binding of arrestin ... of arrestin to photoactivated phosphorylated rhodopsin (R*P[2–5]).Arrestin plays a critical role in visual signalling by completely blocking the ability of R*P to bind and activatetransducin. Arrestin ... phosphopeptide binding [7] or by heparin binding [11], and changes in cysteine reactivitydue to phosphopeptide binding or the activating R175Qmutation [12]. The nature and extent of the conforma-tional...
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Báo cáo Y học: Cloning, chromosomal localization and characterization of the murine mucin gene orthologous to human MUC4 pdf
... found in various proteins. This domain is a part of the nidogenglycoproteins, which are expressed by mesenchymal and epithelial cells. Nidogens have a high affinity for laminin-binding protein and ... molecular mass glycoproteinssynthesized by secretory epithelia. All mucins have a largedomain composed of tandemly repeated sequences rich in serine and threonine residues that carry O-linked oligo-saccharides. ... followed by aSer/Thr-rich region coded by exons 2–8, followed by acysteine-rich region of 139 amino acids (Cys ¼ 7.2%)coded by exons 9–11, a second Ser/Thr-rich region of 374 amino acids coded by...
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Báo cáo Y học: Domain organization, folding and stability of bacteriophage T4 fibritin, a segmented coiled-coil protein docx
... degÆcm2Ædmol)1for fibritin B1 and fibritin SM4, respectively.Interestingly, fibritin M e xhibited more a helicity thanfibritin E, probably due to the absence of insertion loops.The CD spectrum of fibritin F represented ... wild-type fibritin, can be explainedmainly by two residues substitutions. As confirmed by X-ray crystallography [9],the mutation Ser421 to Lyscreated a new salt bridge between residues Lys421 and Glu426. ... enthalpy of the transition f or theE, SM4, SM1 and B1 fibritins increases linearly with anincreasing number of amino-acid r esidues in the coiled-coilregion. In contrast to the independent melting...
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Báo cáo Y học: Isolation, enzymatic properties, and mode of action of an exo-1,3-b-glucanase from Trichoderma viride doc
... was stopped by addition of 1 mL of copper reagent (Somogyi reagent) and boiling for 5 min. Liberated glucose was measured by theSomogyi-Nelson method [34]. To study stability in relation to temperature, ... activity was analyzed by measuringthe amount of glucose released from laminarin. Standardassays (0.25 mL) were in 20 mM sodium acetate buffer,pH 4.5, and contained 0.5 mg of laminarin and crude ... Structuralanalysis of laminarans by MALDI and FAB mass spectrometry.Carbohydr. Res. 310, 203–210.56. Elyakova, L.A. & Zvyagintseva, T.N. (1974) A study of thelaminarins of some Far-Eastern,...
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Báo cáo y học: " Etiological explanation, treatability and preventability of childhood autism: a survey of Nigerian healthcare workers'''' opinion" potx
... mostly diplomas in general and psychiatric nursing, and they had been working in theirvarious areas of specialty for at least 1 year. The study wasa point survey of opinions of healthcare workers ... workerswas often based on the theory of insult to the developingbrain, either as a result of maternal infection, intrauterineinfection or physical trauma to the brain from delivery orbirth ... workers' opin-ions on etiology and other issues relating to prognosis of a particular ailment. Observation of the influence of healthcare worker knowledge and opinions on quantity and quality of information...
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Báo cáo y học: "Residual sleep disturbance and risk of relapse during the continuation/maintenance phase treatment of major depressive disorder with the selective serotonin reuptake inhibitor fluoxetine" docx
... Specifically, a number of studies report anincreased risk of subsequently developing MDD amongnon-depressed individuals complaining of insomnia(that is, insomnia may represent a prodromal symptom)[5,6]. ... found to be significant independentpredictors of early recurrence across treatment groups.Identifying predictors of relapse in MDD is potentiallyclinically relevant, since such predictors could ... Modafinilaugmentation of selective serotonin reuptake inhibitor therapy in MDDpartial responders with persistent fatigue and sleepiness. Ann ClinPsychiatry 2007, 19(Suppl 3):153-159.26. Ravindran...
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Báo cáo y học: " Monocytes are essential for inhibition of synovial T-cell glucocorticoid-mediated apoptosis in rheumatoid arthritis" docx
... cells in a wide range of arthritis types and suggestedthat this finding might be the consequence of reduced inflam-matory cell trafficking to the joints [15]. However, apoptosis induction by ... Exposure of cells to proinflammatory stimuli such as TNF and IL-1 can lead to induction of -isoform of human glucocorticoid receptor(hGR) and suppression of hGR, resulting in diminished glu-cocorticoid ... evaluated by both CD68 and CD163staining (data not shown).The decrease in the ST T -cell population is not mediatedthrough apoptosis induction. Synovial apoptosis evaluated by TUNEL and staining for...
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Báo cáo y học: "Prevalence, clinical relevance and characterization of circulating cytotoxic CD4+CD28– T cells in ankylosing spondylitis" ppt
... surface of CD4+CD28–T cells may beinvolved in a HLA-B27 mediated co-stimulation of theseproinflammatory and cytotoxic cells.Keywords: ankylosing spondylitis, CD28 molecule, CD4+T cells, cytotoxicity, ... independent of age and duration of ankylosing spondylitis. CD4+CD28–T cells produce IFN-γ and perforin, and thus they must be consideredproinflammatory and cytotoxic. These T cells sharephenotypic ... staining for perforin and IFN-γ was performed in activated cells to determine the number of cytokine pro-ducing cells. Production of perforin was more frequent in CD4+CD28–T cells than in...
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Báo cáo y học: "Abnormal costimulatory phenotype and function of dendritic cells before and after the onset of severe murine lupus" pot
... costimulatory molecules, elevated production of cytokines, and increased T cell stimulatory capacity before and after the onset of the disease [14]. In our study we analyzed DCs in the original NZM2410 ... induceperipheral tolerance [25] unless they receive an activation sig-nal, such as CD40 triggering, that induces the production by DCs of large amounts of pro-inflammatory cytokines and stim-ulates T cells ... costimulatory phenotype in lupus diseased mice. (a) To study DCs, we analyzed the total population of splenocytes in mice 6 to 9 months old and gated for CD11c+ cells that were negative for the B-cell...
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