... detectable in OA and RA synovial fluids and joint tissues, and is produced in vitro by both the synovium and chondrocytes in response to inflammatory cytokines [36].MMP-14, produced principally by RA ... and synovial cell hyperplasia. The induction of proinflammatory cytokines produced primarily in the synovium, but also bychondrocytes, results in the upregulation of cartilage-degrading enzymes ... mediators. In RA, mediators involved in immunomodulation and synovial cell function, includingcytokines, chemokines, and adhesion molecules, have primaryroles in the inflammatory and catabolic...