Báo cáo y học: " Efficacy and hypnotic effects of melatonin in shift-work nurses: double-blind, placebo-controlled crossover trial" ppt
Báo cáo y học: " Efficacy and hypnotic effects of melatonin in shift-work nurses: double-blind, placebo-controlled crossover trial" ppt
... melatonin in patients with insomnia than in healthy controls, and Haimov et al [31] found lower levels of urinary 6-sulpha-toxymelatonin in elderly patients with insomnia than in healthy elderly ... about melatonin effect on different kinds of insomnia parameters (difficulty falling asleep, difficultystaying asleep, problem waking up too early, and sleepquality) causing by shift working ... delayed sleep phasesyndrome: clinical and investigative findings in 14 subjects. JNeurol Neurosurg Psychiatry 1992, 55:665-670.39. Tzischinsky O, Dagan Y, Lavie P: The effects of melatonin...
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Báo cáo y học: "Clinical and immunological effects of Rituximab in patients with lupus nephritis refractory to conventional therapy: a pilot study" doc
... analyzed the possible in vivo effect of Rituximab onthe apoptosis of PBMNCs in the patients included in thisstudy. Interestingly, we found an important and significantincrease in the percent of ... activated in vitro with phytohe-magglutinin (PHA).The percent of CD4+ lymphocytes synthesizing IL-10 wasdetermined using the appropriate commercial kit (Miltenyi), fol-lowing the instructions of ... flow cytometry before (day 0), and at days 30 and 90 of Rituximab ther-apy. Data from all samples studied are shown in (a), and representative histograms of flow cytometry analysis are shown in...
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Báo cáo y học: "Do the pleiotropic effects of statins in the vasculature predict a role in inflammatory diseases" pdf
... Namboodiri AM, Singh I: Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages. J Clin Invest 1997, 100:2671-2679.46. ... al.57 Effects of statins beyond lipid lowering in cardiovascular disease?The increasing body of evidence for the efficacy of statins in protecting against vascular events irrespective of cholesterol ... Decreases in triglycerides are particularly strikingwith atorvastatin, and this effect is thought to be attributableto increased binding and clearance of very-low-densitylipoprotein particles in...
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Báo cáo y học: " Ethnomedicinal and ecological status of plants in Garhwal Himalaya, India" pptx
... therapy by exploring medicinalplants: A casestudy of Uttaranchal State in India. In IndigenousKnowledge: Transforming the Academy, Proceedings of an InternationalConferences Pennsylvania: Pennsylvania ... impressive array of speci es and genetic diversity make India one of the 12 mega-biodi-versity countries of the world. Forest represents one of the dominant components of the vegetation of India and forest ... Ethnomedicinal survey of shopian,Kashmir (J&K), India. Asian Journal of Traditional Medicines 2009, 4(1):1-6.21. Curtis JT, Mc Intosh RP: The Interrelation of certain analytic and syntheticphytosociological...
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Báo cáo y học: "Efficacy and safety of aripiprazole in the treatment of bipolar disorder: a systematic review" pdf
... (dehydro-genation, hydroxylation, and N-dealkylation), mainly bycytochrome P450 2D6 (CYP2D6) and cytochrome P4503A4 (CYP3A4) [60]. The parenteral drug is excreted only in traces. There is only ... Pharmacokinetics and tolerability of intra-muscular, oral and intravenous aripiprazole in healthysubjects and in patients with schizophrenia. Clin Pharmacokinet2008, 47:475-485.64. Findling RL, ... discontinuation rate varied and included lack of effi-cacy, side effects (very low percentage) and most impor-tantly the very design and structure of the study (the studywas closed by the sponsor...
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Báo cáo y học: "Passage and reversal effects on gene expression of bovine meniscal fibrochondrocytes" pdf
... are in agreement withprevious studies that have determined the function of COMPto be that of maintaining the integrity and properties of the col-lagen II network by bridging collagen II and ... small and thesame trends are expected to hold. For instance, a proteinexpression study using skeletally mature and immature rabbitfibrochondrocytes expanded in primary and secondary monol-ayer ... post-experimental assays, and statisti-cal analyses described in the study, in addition to drafting theinitial version of the manuscript. KAA supervised the study and oversaw the drafting of the manuscript....
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Báo cáo y học: "Circadian phase-shifting effects of a laboratory environment: a clinical trial with bright and dim light" ppsx
... treat-ment effects were observed for the final laboratory aMT6sDetermining Urinary aMT6s AcrophaseFigure 3Determining Urinary aMT6s Acrophase. An example of analyzing urinary aMT6s is shown. The yellow ... after arising. This repre-sented the final CES-D score.AssaysUrinary concentrations of 6-sulphatoxymelatonin(aMT6s), the primary metabolite of melatonin, wereassayed with a highly specific ... and Anthony C. Cress assisted with this study. The study was performed in Dr. Kripke's lab-oratory in the Department of Psychiatry and Sam and Rose Stein Institute for Research on Aging...
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Báo cáo y học: " The anti-inflammatory effects of the tellurium redox modulating compound, AS101, are associated with regulation of NFB signaling pathway and nitric oxide induction in macrophages" doc
... activitydue to redox-sensitive cysteine residues[27,28].Thus, the effect of AS101 in our experimental systemmay be mediated by in hibition of two steps in the NFBpathway by modifying specific ... enableits anti-inflammatory effects with respect to its ability toreduce pro-inflammatory cytokines and inhibit iNOSexpression and NO release in LPS-stimulatedRAW264.7 macrophages by targeting the ... DNA-bindingabilities in the iNOS promoter. Furthermore, the secre-tion of the inflammator y cytoki ne IL-6, regulated by theNFkB pathway, was significantly inhibited by AS101.These findings...
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Báo cáo y học: " Derivation and preliminary validation of an administrative claims-based algorithm for the effectiveness of medications for rheumatoid arthritis"
... pharmacy data. While clinical disease activity measures remain the gold standard for assessing effectiveness in RA, the many large administrative data sources in the U.S. and internationally are ... written informed consent. VARA contains demographic, clinical and RA-specific information including disease activity scores (DAS), as assessed by physicians using the DAS28 [23] and the Clinical ... data for a number of rheumatology conditions including diagnoses for RA, spondyloarthropathies, systemic lupus erythematosus, fibromyalgia, osteoarthritis, joint injection, and joint replacement...
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Báo cáo y học: " Induction and effector phase of allergic lung inflammation is independent of CCL21/CCL19 and LT-beta
... cascade of cytokines and chemokines necessary for tissue eosinophilia without involvement of draining lymphoid tissues. We studied the induction of lung allergic in- flammation in mice lacking ... the last intranasal challenge. Briefly, mice were maintained inside a whole-body plethysmograph (Buxco, Troy, NY) capable of meas-uring changes in airflow and trans-thoracic pressures and resistances ... the cytokines IL-4 and IL-13, which in turn induced epithelial production of the eosinophil chemokine eotaxin [28]. Since local Th2 cell produc-tion of cytokines has also been implicated in...
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