... metalloproteinase domain; ADAMTS: a disintegrin and metalloproteinase domain with thrombospondin motifs; Ct: threshold cycle; IGF: insulin-like growth factor; IL: interleukin; MMP: matrix metalloproteinase; ... predominantly intracellularly [26,27]. Cathepsin H,cathepsin C, cathepsin F, cathepsin W, cathepsin B andcathepsin S are also increased in expression in OA tissueTable 3Fold change and threshold cycle ... Fujita Y, Mat-sumoto H, Sehara-Fujisawa A, Iwamoto Y, Okada Y: ADAM-12(meltrin alpha) is involved in chondrocyte proliferation viacleavage of insulin-like growth factor binding protein 5 in oste-oarthritic...