... central part of a bone
composed of an anastomosing network
of trabecular or cancellous bone (ii) the
central part of the kidney (iii) the central
part of a lymph node (iv) the central part
of the ... at
11q23
• MLL-FBP 17 in ins(11;9)(q23;q34)
inv(11)(q13q23)
• MLL-CALM in inv(q14,2q23.1)
• MLL-GPNH in t(11;14)(q23;q24)
• MLL-AF 17 in t(11; 17) (q23;q21)
• MLL-RARA in t(...
... transformation of myelopro-
liferative disorders, forming AML 1-
EAP, AML1-EVI1 and AML-MDS1
• part of ETV6 to form a fusion gene,
ETV6-AML1 (TEL-AML1), detected
in about 30% of cases of acute lymph-
oblastic ... locus)
-3 -N-acetyl D
galactosylaminyltransferase
(encoded by
A
1
allele* at the
ABO locus)
AB
(b)
Locus Allele Transferase
FUT1
ABO
H
h
A
B
O
-2 -L-fucosyltrans...
... ex-
pression in about a third of cases of acute
leukaemia and chronic granulocytic leuk-
aemia, particularly in blast crisis
DDAVP 1-deamino-6-D-arginine vaso-
pressin, desmopressin acetate
D-dimer ... deletion of part of a chromo-
some, either part of the long arm or part
of the short arm (del) (ii) deletion of a
DNA sequence with the regions on either
side being rejoined...
... cells of the
majority of cases of B-lineage acute
lymphoblastic leukaemia, more weakly on
the blast cells of some cases of T-lineage
acute lymphoblastic leukaemia, on the
cells of many cases of ... used for the treatment
of T-cell leukaemias and lymphomas and,
together with anti-CD3, for the treatment
of acute graft-versus-host disease
CD7 is expressed on blast cells of T...
... cells
CD 27 is often expressed on neoplastic
B cells, e.g. in most cases of chronic lym-
phocytic leukaemia, three-quarters of cases
of follicular lymphoma and two-thirds of
cases of diffuse large B-cell ... glycolipid, GD3
CD60b a glycolipid, 9-O-acetyl-GD3
CD60c a glycoclipid, 7- O-acetyl-GD3
CD61 a surface membrane glycoprotein,
the β3 integrin chain, GpIIIa; part of
the G...
... about
10% of cases of multiple myeloma and
in about 10% of cases of non-Hodgkin’s
lymphoma, particularly MALT-type
non-Hodgkin’s lymphoma and extra-
nodal B-lineage diffuse large cell
lymphoma
FBP 17 ... 113
Glucose
ATP
ADP
Hexokinase
Glucose-6-phosphate
Fructose-6-phosphate
Fructose-1,6-diphosphate
Glyceraldehyde-
3-phosphate
1,3-biphosphoglycerate
3-phosphoglycerate
2-phosphoglyc...
... 210
Table 16 Some of the genetic causes of severe combined immunodeficiency.
Defect
Deficiency of Janus-associated
kinase 3
Deficiency of common γ chain
of receptors for IL-2, IL-4, IL -7 ,
IL-9 and IL ... rearrange-
ment of the regions of an immunoglo-
bulin or T-cell receptor gene (see Fig. 46,
p. 135)
red cell an erythrocyte, a non-nucleated
cell of the peripheral blood the...
... in
blast cells of 88% of cases of acute lym-
phoblastic leukaemia and 97% of cases of
acute myeloid leukaemia.
Wolman’s disease an inherited meta-
bolic disorder, a juvenile form of choles-
terol ester ... homo-
zygosity for a mutation in this gene
V
2 27
HAE-V 01/13/2005 05:17PM Page 2 27
interferon-γ and lymphocytotoxin (tumour
necrosis factor β) but not interleukin-4,
interle...