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Báo cáo y học: "Granulocyte-CSF induced inflammation-associated cardiac thrombosis in iron loading mouse heart and can be attenuated by statin therapy" pptx

Báo cáo y học:

Báo cáo y học: "Granulocyte-CSF induced inflammation-associated cardiac thrombosis in iron loading mouse heart and can be attenuated by statin therapy" pptx

... AccessGranulocyte-CSF induced inflammation-associated cardiac thrombosis in iron loading mouse heart and can be attenuated by statin therapyWei S Lian2,3†, Heng Lin4†, Winston TK Cheng5, ... inflammation -thrombosis circuitry and that leadsto intra -cardiac thrombu s formation. This inflamma tion-associated cardiac thrombosis in vivo can be attenuated by simvastatin therapy, but not by tirofiban ... 11 of 15 loading and G-CSF to mice to test our hypothesis by examining the incidence of cardiovascular thrombosis. Interestingly, intra -cardiac thrombus formation wasobserved in iron and G-CSF...
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Báo cáo y học: "Collagen-induced arthritis is exacerbated in IL-10-deficient mice" pps

... transcription in human monocytes. Blood 1997, 89:4461.10. Ding L, Linsley PS, Huang LY, Germain RN, Shevach EM: IL-10inhibits macrophage costimulatory activity by selectivelyinhibiting the up-regulation ... in rheumatoid arthritis by interleukin-10 and interleukin-4. Arthri-tis Rheum 1996, 39:829.19. Walmsley M, Katsikis PD, Abney E, Parry S, Williams RO, MainiRN, Feldmann M: Interleukin-10 inhibition ... ofcytokines by mouse B cells: B lymphomas and normal B cellsproduce interleukin 10. Int Immunol 1990, 2:821.5. de Waal Malefyt R, Abrams J, Bennett B, Figdor CG, de Vries JE:Interleukin 10...
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Báo cáo y học: "Interferon-induced protein IFIT4 is associated with systemic lupus erythematosus and promotes differentiation of monocytes into dendritic cell-like cells" pdf

... leucopenia,thrombocytopenia and C3/C4 decrease. IFIT4 protein waslocalized exclusively to the cytoplasm, and it was significantlyupregulated by IFN-α in normal PBMCs. To determine the roleplayed by IFIT4 in ... kinase Cδ, c-Junamino-terminal kinase, and STAT1 (signal transducer and acti-vator of transcription 1) [36]. Because IFIT4 can be induced by IFN-α [36], which is involved in monocyte differentiation[2,19,20,27,37], ... autoimmuneresponses in SLE by inducing DCs [27]. However, the mech-anism by which IFN-α induces monocytes to differentiate intoDCs has not been elucidated.Recently, a gene expression study using an oligonucleotidemicroarray...
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Báo cáo y học: "The identification of eosinophilic gastroenteritis in prednisone-dependent eosinophilic bronchitis and asthma" potx

... conventional eosin and hematoxylin staining of the tissue was not inter-preted as being significant by two independent patholo-gists. The other eosinophil granules such as ECP [10] and EDN [ 11] ... a patient who likelyhas a lymphocytic variant of hypereosinophilic syndromethat resulted in eosinophilic infiltration of the gastroin-testinal tract, sinuses, and airway that contributed tovariable ... association of eosinophilic gastrointestinal disease with eosinophilic bronchitis, asthma and chronic rhinosinusitis and some features of lymphocytic hypereosinophilic syndrome, describes a diagnosticprotocol...
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Báo cáo y học: " From antibody insult to fibrosis in neonatal lupus – the heart of the matter" pps

... varying degrees of pathology parallel the resultsobtained exploiting in vitro coculturing systems. Physiologicapoptosis may initiate an inflammatory process via antibodybinding and ingestion by ... tissue may be unique to heart blockacquired in utero following autoantibody-initiated inflam-mation. Other inflammatory stimuli, as in Lyme disease,induce transient block [26], arguing against ... critical linkbetween inflammation and ultimate scarring by secretionof alkaline phosphatases, resulting in increased calcifica-tion [24]. In fact, macrophages could be seen contained in areas...
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Báo cáo y học: "Regional characterization of energy metabolism in the brain of normal and MPTP-intoxicated mice using new markers of glucose and phosphate transport" doc

... previously been shown that a general inhi-bition of cell glycosylation by tunicamycin a llowedreceptorrecognitionandinfectiondrivenbyanMLVenvelope [27]. W hether, a lack of staining may comefrom ... of 9Cerebellum staini ng: the granular layer was irregularlylabelled with all three probes, whereas the molecularlayer was homogeneously labelled for PiT1 and PiT2 and i rregularly labelled ... can transport zinc in the bacteria E. Coli[36]. Interestingly, vitamin C and zinc support majorpathophysiological pathways: vitamin C is an endogenousantioxidant [37] and zinc is the cofactor...
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Báo cáo y học: "The role of a pseudocapsula in thymic epithelial tumors: outcome and correlation with established prognostic parameters. Results of a 20-year single centre retrospective analysis" pptx

... dif-ference in survival was determined by using the log-ranktest and in case of significance a univariate analysis and Cox-regression analysis was carried out.ResultsPathological and Clinical FindingsAccording ... with anincidence of 0.2 – 1.5% worldwide [1]. A larger body ofliterature has been presented in the last decades providingfurther insight into tumor biology and clinical behaviourof thymomas ... wasfound to result in lower recurrence rate in patients withincomplete resected thymomas in stage IV [23,24]. In our study chemotherapy was given in 5 cases only in stage IV and recurrence rate...
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Báo cáo y học: " Histology of adipose tissue inflammation in Dercum’s disease, obesity and normal weight controls: a case control study" doc

... biopsy and stained with hematoxylin-eosin. The whole sectionswere examined by the same pathologist (US) in ablinded manner. The inflammatory reaction consisted oflymphocytes, macrophages and ... without inflammation [8,10]. H owever, pathologicalfindings have been described in other studies. Dercumoriginally considered the most interestin g histologicalfinding to be interstitial inflammation ... against native DNA, arecommonly negative in DD [4,6,11,15]. Regarding bloodcytokines, a small study including 1 0 subjects and 5controls [19] indicated that macrophage inflammatoryprotein...
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Báo cáo Y học: Rapid caspase-dependent cell death in cultured human breast cancer cells induced by the polyamine analogue N1,N11-diethylnorspermine pdf

Báo cáo Y học: Rapid caspase-dependent cell death in cultured human breast cancer cells induced by the polyamine analogue N1,N11-diethylnorspermine pdf

... putres-cine, spermidine and spermine by down-regulating theactivity of the polyamine biosynthetic enzymes a nd up-regu-lating the activity of the catabolic enzyme spermidine/spermine N1-acetyltransferase ... etabolicpathway, the induction of SSAT results in the acetylation ofspermine and spermidine, which are subsequently oxidized by polyamine oxidase to form spermidine and putrescine,respectively. In addition, ... polyamine a naloguesare presently undergoing Phase I and Phase II clinicalevaluations in the US. In L56Br-C1 cells, DENSPM treatment induced anincrease in SSAT activity, which resulted in...
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Báo cáo Y học: Ligand-induced heterodimerization between the ligand binding domains of the Drosophila ecdysteroid receptor and ultraspiracle docx

Báo cáo Y học: Ligand-induced heterodimerization between the ligand binding domains of the Drosophila ecdysteroid receptor and ultraspiracle docx

... expressed in yeast was functional and bound radioactively labelled ecdysteroid specifically.Ligand binding was greatly enhanced by the presence of aUSP ligand binding domain. Therefore, ecdysteroids ... assayed by the two-hybrid assay (rI: induced level divided by basallevel of b-galactosidase activity): + or – signs mean rI to be signifi-cantly or unsignificantly higher than 1, respectively; ... greatly enhanced upon adminis-tration of active ecdysteroids in a dose-dependent manner.This was shown in vivo by a yeast two-hybrid system and in vitro by a modified electromobility shift assay....
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